CC BY 4.0 · TH Open 2021; 05(02): e171-e173
DOI: 10.1055/s-0041-1728664
Case Report

Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Kiyoko Kanosue
1  Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan
,
Satomi Nagaya
2  Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
,
Eriko Morishita
2  Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
,
Masayoshi Yamanishi
1  Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan
,
3  Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan
› Author Affiliations
Funding None.

Abstract

A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation.

Policy and Ethics

The work was performed in accordance with the Declaration of Helsinki with approval by the Institutional Ethics Committee.


Supplementary Material



Publication History

Received: 20 January 2021

Accepted: 23 February 2021

Publication Date:
26 May 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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