Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Kiyoko Kanosue; Satomi Nagaya; Eriko Morishita; Masayoshi Yamanishi; Shinsaku Imashuku

doi:10.1055/s-0041-1728664

TH Open, Inhaltsverzeichnis

CC BY 4.0 · TH Open 2021; 05(02): e171-e173
DOI: 10.1055/s-0041-1728664

Case Report

Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Kiyoko Kanosue

¹Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan

,

Satomi Nagaya

²Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

,

Eriko Morishita

²Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

,

Masayoshi Yamanishi

¹Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji, Japan

,

Shinsaku Imashuku

³Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan

› Institutsangaben

Abstract

A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation.

Keywords

visceral vein thrombosis - protein C deficiency - Clostridium perfringens - septicemia - older adult

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Referenzen

References
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