CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2021; 12(01): 031-035
DOI: 10.1055/s-0041-1728232
Original Article

Current Trends in Etiological Profile of Acute Upper Gastrointestinal Bleeding in Northern India: A Retrospective Analysis of 5-Year Endoscopic Data

Vishal Bodh
1   Department of Gastroenterology, IGMC, Shimla, Himachal Pradesh, India
,
Brij Sharma
1   Department of Gastroenterology, IGMC, Shimla, Himachal Pradesh, India
,
Rajesh Kumar
1   Department of Gastroenterology, IGMC, Shimla, Himachal Pradesh, India
,
Rajesh Sharma
1   Department of Gastroenterology, IGMC, Shimla, Himachal Pradesh, India
› Author Affiliations
Source(s) of Support None.

Abstract

Introduction The etiological spectrum of acute upper gastrointestinal bleeding (AUGIB) varies from region to region. This study was performed to find out the latest etiological spectrum of the AUGIB in a tertiary care hospital in North India and to compare it with etiological spectra from a previous study from the same center and from the other regions of India.

Methods Clinical notes and endoscopic data of all consecutive patients who had presented with AUGIB in Indira Gandhi Medical College Shimla, Himachal Pradesh, from May 2015 to December 2019, were analyzed retrospectively with the objective of finding out the various endoscopic etiologies that lead to AUGIB. The findings were compared with the previous study from the same center and with the data from the other regions of the country.

Results A total of 1,513 patients were enrolled and majority were males (74.6%) with male:female ratio of 2.9:1. Majority were 41 to 60 years (46.46%) of age. Melena was the presenting complaint in 93.98% and hematemesis in 46.06%. Peptic ulcer disease (PUD; 46.19%) was the commonest cause of AUGIB followed by portal hypertension (26.23%). Other less common causes were erosive mucosal disease, erosive esophagitis, neoplasm, Mallory–Weiss tear, gastric angiodysplasia, anastomotic site ulcers, and Dieulafoy’s lesion.

Conclusion PUD was still the commonest cause of AUGIB followed by portal hypertension. This is in agreement with the previous report from the same center and in contrast to the reports from other studies from Northern and Western India that create the impression that portal hypertension related bleeding is the most common cause of AUGIB in India.



Publication History

Article published online:
20 April 2021

© 2021. Society of Gastrointestinal Endoscopy of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Ghosh S, Watts D, Kinnear M. Management of gastrointestinal haemorrhage. Postgrad Med J 2002; 78 (915) 4-14
  • 2 Rockall TA, Logan RF, Devlin HB., Northfield TC. National Audit of Acute Upper Gastrointestinal Haemorrhage. Selection of patients for early discharge or outpatient care after acute upper gastrointestinal haemorrhage. Lancet 1996; 347 (9009) 1138-1140
  • 3 Thomopoulos KC, Vagenas KA, Vagianos CE. et al. Changes in aetiology and clinical outcome of acute upper gastrointestinal bleeding during the last 15 years. Eur J Gastroenterol Hepatol 2004; 16 (02) 177-182
  • 4 Ginn JL, Ducharme J. Recurrent bleeding in acute upper gastrointestinal hemorrhage: transfusion confusion. CJEM 2001; 3 (03) 193-198
  • 5 van Leerdam ME. Epidemiology of acute upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol 2008; 22 (02) 209-224
  • 6 Frugis S, Czeczko NG, Malafaia O. et al. Prevalence of Helico-bacter pylori ten years ago compared to the current prevalence in patients undergoing upper endoscopy. Arq Bras Cir Dig 2016; 29 (03) 151-154
  • 7 Jiang M, Chen P, Gao Q. Systematic review and net-work meta-analysis of upper gastrointestinal hemorrhage interventions. Cell Physiol Biochem 2016; 39 (06) 2477-2491
  • 8 Roberts-Thomson IC. Rise and fall of peptic ulceration: a disease of civilization?. J Gastroenterol Hepatol 2018; 33 (07) 1321-1326
  • 9 Jaskolka JD, Binkhamis S, Prabhudesai V, Chawla TP. Acute gastrointestinal hemorrhage: radiologic diagnosis and management. Can Assoc Radiol J 2013; 64 (02) 90-100
  • 10 Kashyap R, Mahajan S, Sharma B. et al. A clinical profile of acute upper gastrointestinal bleeding at moderate altitude. JIACM 2005; 6: 224-228
  • 11 Krishnakumar R, Padmanabhan P, kumar Prem, Selvi C, kumar Ram, Joe A. Upper GI bleed- a study of 408 cases. Indian J Gastroenterol 2007; 26 (suppl 2) A133
  • 12 Parvez M, Goenka MK, Tiwari IK, Goenka U. Spectrum of upper gastrointestinal bleed: an experience from eastern India. J Dig Endosc 2016; 7: 55-61
  • 13 Gajendra O, Ponsek T, Varghese J, Sadasivan S, Nair P, Narayanan VA. Single center study of upper GI endoscopic findings in patients with overt and occult upper GI bleed. Indian J Gastroenterol 2009; 28: A111
  • 14 Singh SP, Panigrahi MK. Spectrum of upper gastrointestinal hemorrhage in coastal Odisha. Trop Gastroenterol 2013; 34 (01) 14-17
  • 15 Mahajan P, Chandail VS. Etiological and endoscopic profile of middle aged and elderly patients with upper gastrointestinal bleeding in a tertiary care hospital in North India: a retrospective analysis. J Midlife Health 2017; 8 (03) 137-141
  • 16 Prasad NRV, Ali SM, Ganapathy V, Sreenath GS, Kumar SS. Acute upper gastrointestinal bleeding in a tertiary care hospital in South India - have we improved the outcomes?. Trop Gastroenterol 2016; 37 (03) 168-176
  • 17 Marmo R, Koch M, Cipolletta L. et al. Italian registry on upper gastrointestinal bleeding (Progetto Nazionale Emorragie Digestive–PNED 2). Predicting mortality in non-variceal upper gastrointestinal bleeders: validation of the Italian PNED Score and prospective comparison with the Rockall Score. Am J Gastroenterol 2010; 105 (06) 1284-1291
  • 18 Anand CS, Tandon BN, Nundy S. The causes, management and outcome of upper gastrointestinal haemorrhage in an Indian hospital. Br J Surg 1983; 70 (04) 209-211
  • 19 Rathi P, Abraham P, Jakareddy R, Pai N. Spectrum of upper gastrointestinal bleeding in western India. Indian J Gastroenterol 2001; 20 (suppl 2) A37
  • 20 Romagnuolo J, Barkun AN, Enns R, Armstrong D, Gregor J. Simple clinical predictors may obviate urgent endoscopy in selected patients with nonvariceal upper gastrointestinal tract bleeding. Arch Intern Med 2007; 167 (03) 265-270
  • 21 Report of the National Commission on Macroeconomics and Health. Ministry of Health and Family Welfare. Government of India, New Delhi, 2005
  • 22 Wara P. Incidence, diagnosis, and natural course of upper gastrointestinal hemorrhage. Prognostic value of clinical factors and endoscopy. Scand J Gastroenterol Suppl 1987; 137: 26-27
  • 23 Das K. Endoscopy outreach and upper gastrointestinal bleed: an audit. Indian J Gastroenterol 2014; 33 (05) 478-479
  • 24 Banerjee A, Bishnu S, Dhali GK. Acute upper gastrointestinal bleed: an audit of the causes and outcomes from a tertiary care center in eastern India. Indian J Gastroenterol 2019; 38 (03) 190-202