CC BY-NC-ND 4.0 · J Neurosci Rural Pract 2021; 12(03): 530-534
DOI: 10.1055/s-0041-1727575
Original Article

Leprous Neuropathy: Observational Study Highlighting the Role of Electrophysiology in Early Diagnosis

Beena V. Vijayan
1  Department of Neurology, Government Medical College Hospital, Affiliated to Kerala University of Health Sciences, Kottayam, Kerala, India
Maria R. Dominic
1  Department of Neurology, Government Medical College Hospital, Affiliated to Kerala University of Health Sciences, Kottayam, Kerala, India
Vijayan C.P. Nair
2  Kerala University of Health Sciences, Thrissur, Kerala, India
› Author Affiliations


Background Worldwide leprosy is a common cause of peripheral neuropathy. Electrophysiology is underutilized in its diagnosis.

Objective This study aims to evaluate the usefulness of electrophysiological study in the diagnosis of leprous neuropathy.

Materials and Methods Clinical and electrophysiological abnormalities of 36 histopathology proven leprosy patients from January 2015 to January 2017 were studied.

Statistical Analysis Proportions were compared by Chi-square test.

Results Total patients were 36. Thirty-four patients had abnormal electrophysiology and 34 had neurological deficits like weakness, sensory changes, and thickening. By clinical examination, multiple nerve involvement (motor weakness, sensory changes, and nerve thickening) occurred in 29, single nerve in 5, and no nerve involvement in 2. With electrophysiology, multiple nerve involvement (mononeuritis multiplex) was present in 32, single nerve in 2, and normal conduction parameters in 2. From the 36 patients, a total of 1,008 nerves were subjected to clinical examination and 132 were picked up clinically as affected, (13.1%). Electrophysiological study was done in 504 nerves, and 215 were found to be involved, (43%). Nerve abnormality detected by electrophysiology is significantly higher than clinical detection. (Chi-square =164.4054; p = 0.0000). Clinically, the most commonly affected nerve was unar (27) and the least affected was median (2) nerve. Electrophysiology detected 69% of nerves with demyelination and 35% of nerves with axonal features (mosaic pattern).

Discussion There was subclinical neuropathy with electroclinical dissociation, as evidenced by more abnormality in electrophysiology than clinical examination. The nerve involvement was mononeuritis or mononeuritis multiplex pattern, both clinically and electrophysiologically. Electrophysiology showed both axonal and demyelinating nerve involvement (mosaic pattern). All the three features are present in leprous neuropathy. In corollary, if a patient has these electrophysiological features, he should be thoroughly investigated for leprosy.

Conclusion Triple findings, such as subclinical neuropathy with electroclinical dissociation, mononeuritis multiplex, and mosaic pattern of demyelination and axonopathy, suggest leprous neuropathy

Publication History

Publication Date:
16 June 2021 (online)

© 2021. Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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