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DOI: 10.1055/s-0041-1727185
Radioembolization in Metastatic Breast Cancer
Funding A.D. was funded by BTG, Dova Pharmaceuticals, and Sirtex Medical.
Abstract
Metastatic breast cancer (MBC) remains the second cause of cancer death in women, despite improvements in early breast cancer detection and treatments, with a 5-year survival of only 27%. Patients with MBC involving the liver have a 5-year survival of only 3.8 to 12%. Systemic therapy is the cornerstone for the treatment of MBC according to the National Comprehensive Cancer Network (NCCN) guidelines. Radioembolization is not specifically prescribed by the NCCN guidelines in the treatment of MBC liver metastasis, but is an emerging therapy with some promising results. The two primary reasons to offer radioembolization would be to prolong life and to palliate and improve quality of life. We review here the indications, contraindications, technique, case examples, and unanswered questions.
Publication History
Received: 19 November 2020
Accepted: 16 February 2021
Article published online:
17 May 2021
© 2021. Thieme. All rights reserved.
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References
- 1 American Cancer Society (ACS). Cancer Facts & Figures 2019. Atlanta: American Cancer Society; 2019
- 2 Howlader N, Noone AM, Krapcho M. et al, eds. SEER Cancer Statistics Review, 1975–2016, National Cancer Institute. Bethesda, MD. Accessed March 10, 2021 at: https://seer.cancer.gov/csr/1975_2016/
- 3 Harris JR. Cancer of the breast. In: DeVita VT, Hellman S, Rosenberg SA. eds. Cancer: Cancer Principles and Practice of Oncology. Philadelphia, PA: J.B. Lippincott Company; 1993: 1264-1332
- 4 O'Shaughnessy J. Extending survival with chemotherapy in metastatic breast cancer. Oncologist 2005; 10 (Suppl. 03) 20-29
- 5 Adam R, Aloia T, Krissat J. et al. Is liver resection justified for patients with hepatic metastases from breast cancer?. Ann Surg 2006; 244 (06) 897-907 , discussion 907–908
- 6 Leung AM, Vu HN, Nguyen KA, Thacker LR, Bear HD. Effects of surgical excision on survival of patients with stage IV breast cancer. J Surg Res 2010; 161 (01) 83-88
- 7 Xie J, Xu Z. A population-based study on liver metastases in women with newly diagnosed breast cancer. Cancer Epidemiol Biomarkers Prev 2019; 28 (02) 283-292
- 8 Liedtke C, Kolberg HC. Systemic therapy of advanced/metastatic breast cancer-current evidence and future concepts. Breast Care (Basel) 2016; 11 (04) 275-281
- 9 Chua TC, Saxena A, Liauw W, Chu F, Morris DL. Hepatic resection for metastatic breast cancer: a systematic review. Eur J Cancer 2011; 47 (15) 2282-2290
- 10 Cholapranee A, van Houten D, Deitrick G. et al. Risk of liver abscess formation in patients with prior biliary intervention following yttrium-90 radioembolization. Cardiovasc Intervent Radiol 2015; 38 (02) 397-400
- 11 Gabr A, Riaz A, Johnson GE. et al. Correlation of Y90-absorbed radiation dose to pathological necrosis in hepatocellular carcinoma: confirmatory multicenter analysis in 45 explants. Eur J Nucl Med Mol Imaging 2021; 48 (02) 580-583
- 12 Davisson NA, Bercu ZL, Friend SC. et al. Predictors of survival after yttrium-90 radioembolization of chemotherapy-refractory hepatic metastases from breast cancer. J Vasc Interv Radiol 2020; 31 (06) 925-933