CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2021; 11(03): 126-129
DOI: 10.1055/s-0041-1726683
Review Article

Oral Fluids—A Diagnostic Tool for COVID-19: A Review

Amitha Ramesh
1   A.B. Shetty Memorial Institute of Dental Sciences, NITTE (deemed to be) University, Mangalore, Karnataka, India
,
Raksha Potdar
1   A.B. Shetty Memorial Institute of Dental Sciences, NITTE (deemed to be) University, Mangalore, Karnataka, India
,
Rahul Bhandary
1   A.B. Shetty Memorial Institute of Dental Sciences, NITTE (deemed to be) University, Mangalore, Karnataka, India
› Author Affiliations

Abstract

Global outbreak of coronavirus disease 2019 (COVID-19) in December 2019 has affected millions of people around the world. This virus binds to angiotensin-converting enzyme-2 receptors present in the pharynx, nose, oral cavity, salivary glands, tongue, etc. Saliva has been shown to have viral loads of COVID-19 as it reported to be 2019-novel-coronavirus nucleic acid positive. This article is based on the association of oral fluids and their role in diagnosis of coronavirus infection.



Publication History

Article published online:
14 May 2021

© 2021. Nitte (Deemed to be University). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Baghizadeh Fini M. What dentists need to know about COVID-19. Oral Oncol 2020; 105 (Apr) 104741
  • 2 Khurshid Z, Asiri FYI, Al Wadaani H. Human saliva: non-invasive fluid for detecting novel Coronavirus (SARS-CoV-2).. Int J Environ Res Public Health 2020; 17 (07) 2225
  • 3 Wyllie AL, Fournier J, Casanovas-Massana A, et al. Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs. Medrxiv 2020; doi: https://doi.org/10.1101/2020.04.16.20067835
  • 4 Gomes-Filho IS, Passos JS, Seixas da Cruz S. Respiratory disease and the role of oral bacteria. J Oral Microbiol 2010; 2
  • 5 Quinn B, Giuliano KK, Baker D. Non-ventilator health care-associated pneumonia (NV-HAP): best practices for prevention of NV-HAP. Am J Infect Control 2020; 48 (5S) A23-A27
  • 6 Xu J, Li Y, Gan F, Du Y, Yao Y. Salivary glands: potential reservoirs for COVID-19 asymptomatic infection. J Dent Res 2020; 99 (08) 989
  • 7 Chen L, Zhao J, Peng J. et al. Detection of 2019-nCoV in saliva and characterization of oral symptoms in COVID-19 patients. Cell Prolif 2020; 53 (12) e12923
  • 8 Bergdahl M, Bergdahl J. Low unstimulated salivary flow and subjective oral dryness: association with medication, anxiety, depression, and stress. J Dent Res 2000; 79 (09) 1652-1658
  • 9 Farshidfar N, Hamedani S. Hyposalivation as a potential risk for SARS-CoV-2 infection: inhibitory role of saliva. Oral Dis 2021; 27 (Suppl. 03) 750-751
  • 10 Fu L, Wang B, Yuan T. et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. J Infect 2020; 80 (06) 656-665
  • 11 Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di RNapoli. Features, evaluation and treatment of coronavirus (COVID-19). Statpearls 2020. Accessed April 14, 2020 at: https://www.ncbi.nlm.nih.gov/books/NBK554776/
  • 12 Zhou F, Yu T, Du R. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395 (102/29) 1054-1062
  • 13 Isho B, Abe KT, Zuo M. et al. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol 2020; 5 (52) eabe5511
  • 14 To KK-W, Tsang OT, Leung WS. et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis 2020; 20 (05) 565-574
  • 15 To KK, Tsang OT, Yip CC. et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis 2020; 71 (15) 841-843
  • 16 To KK-W, Tsang OT, Leung WS. et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis 2020; 20 (05) 565-574
  • 17 Zhang W, Du RH, Li B. et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect 2020; 9 (01) 386-389
  • 18 Chen L, Zhao J, Peng J. et al. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients. Cell Prolif 2020; 53 (12) e12923
  • 19 Wang W, Xu Y, Gao R. et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA 2020; 323 (18) 1843-1844
  • 20 Wang YC, Lee YT, Yang T, Sun JR, Shen CF, Cheng CM. Current diagnostic tools for coronaviruses-from laboratory diagnosis to POC diagnosis for COVID-19. Bioeng Transl Med 2020; 5 (03) e10177
  • 21 Butler-Laporte G, Lawandi A, Schiller I. et al. Comparison of saliva and nasopharyngeal swab nucleic acid amplification testing for detection of SARS-CoV-2: a systematic review and meta-analysis. JAMA Intern Med 2021; e208876
  • 22 Bastos ML, Perlman-Arrow S, Menzies D, Campbell JR. The sensitivity and costs of testing for SARS-CoV-2 infection with saliva versus nasopharyngeal swabs: a systematic review and meta-analysis. Ann Intern Med 2021; 174 (04) 501-510
  • 23 Czumbel LM, Kiss S, Farkas N. et al. Saliva as a candidate for COVID-19 diagnostic testing: a meta-analysis. Front Med (Lausanne) 2020; 7: 465
  • 24 Chen X, Zhao B, Qu Y. et al. Detectable serum Severe Acute Respiratory Syndrome Coronavirus 2 viral load (RNAemia) is closely correlated with drastically elevated interleukin 6 level in critically ill patients with Coronavirus disease 2019. Clin Infect Dis 2020; 71 (08) 1937-1942
  • 25 Chen W, Lan Y, Yuan X. et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes and Infect 2020; 9: 469-473
  • 26 Gutmann C, Takov K, Burnap S. et al. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. Res Square 2021; 12 (01) 3406
  • 27 Bermejo-Martin JF, González-Rivera M, Almansa R. et al. Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Crit Care 2020; 24 (01) 691
  • 28 Veyer D, Kernéis S, Poulet G. et al. Highly sensitive quantification of plasma SARS-CoV-2 RNA sheds light on its potential clinical value. Clin Infect Dis 2020; ciaa1196
  • 29 Huergo LF, Selim KA, Conzentino MS. et al. Magnetic bead-based immunoassay allows rapid, inexpensive, and quantitative detection of human SARS-CoV-2 antibodies. ACS Sens 2021; 6 (03) 703-708
  • 30 Rodriguez-Manzano J, Malpartida-Cardenas K, Moser N. et al. Handheld point-of-care system for rapid detection of SARS-CoV-2 extracted RNA in under 20 min. ACS Cent Sci 2021; 7 (02) 307-317