PDF herunterladen
CC BY-NC-ND 4.0 · J Neurol Surg Rep 2021; 82(02): e11-e16
DOI: 10.1055/s-0041-1726305
Case Report

Tonsillar Carcinoma Spreading Metastases to Central Nervous System: Case Report and Literature Review

Shujhat Khan 
1   Department of Medicine, Imperial College London, London, United Kingdom
,
Giulio Anichini
2   Department of neurosurgery, Charing Cross Hospital, London, United Kingdom
,
Areeb Mian
1   Department of Medicine, Imperial College London, London, United Kingdom
,
Haider Kareem
2   Department of neurosurgery, Charing Cross Hospital, London, United Kingdom
,
Nelofer Syed
2   Department of neurosurgery, Charing Cross Hospital, London, United Kingdom
,
Kevin O'Neill
2   Department of neurosurgery, Charing Cross Hospital, London, United Kingdom
› Institutsangaben Funding None.
› Weitere Informationen
   Lizenzen und Reprints

Abstract

We present a case report of a 51-year-old left-handed male with a background of human papillomovairus 16-positive tonsil squamous cell carcinoma presenting with tonic-clonic seizure and a radiological diagnosis of secondary metastatic deposits. These were initially treated with stereotactic radiosurgery and subsequently with surgery. Surgical resection was performed under general anesthesia with right-sided temporal and parietal approaches. Both the parietal and temporal deposits were removed, while the intraventricular mass was intentionally left to avoid postoperative deficits. Adjuvant radiotherapy and chemotherapy were administered postoperatively. The patient experienced a satisfactory recovery postoperatively and was reoperated for recurrence 4 months later. He maintained a good quality of life and an excellent performance status throughout, but unfortunately he passed away in November 2018 due to septic complications. This case history stresses the difficulty in managing squamous cell carcinomas (SCC) with brain metastatic deposits. There are no current guidelines about the management of patients presenting with such a rare condition. More data are thus desirable to better define treatment guidelines and protocols when SCC brain metastases are present.

Keywords

central nervous system metastasis - tonsillar squamous cell carcinoma - neurosurgery - oncology


Publikationsverlauf

Eingereicht: 10. Juni 2020

Angenommen: 17. November 2020

Artikel online veröffentlicht:
14. Juni 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Vigneswaran N, Williams MD. Epidemiologic trends in head and neck cancer and aids in diagnosis. Oral Maxillofac Surg Clin North Am 2014; 26 (02) 123-141
    CrossrefPubMedGoogle Scholar
  • 2 Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. Cancer 2005; 103 (09) 1843-1849
    CrossrefPubMedGoogle Scholar
  • 3 Hocking JS, Stein A, Conway EL. et al. Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers. Br J Cancer 2011; 104 (05) 886-891
    CrossrefPubMedGoogle Scholar
  • 4 Blot WJ, McLaughlin JK, Winn DM. et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 1988; 48 (11) 3282-3287
    PubMedGoogle Scholar
  • 5 Oh JE, Kim JO, Shin JY. et al. Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes. Int J Oncol 2013; 43 (02) 383-393
    CrossrefPubMedGoogle Scholar
  • 6 Rampias T, Sasaki C, Weinberger P, Psyrri A. E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells. J Natl Cancer Inst 2009; 101 (06) 412-423
    CrossrefPubMedGoogle Scholar
  • 7 Näsman A, Attner P, Hammarstedt L. et al. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?. Int J Cancer 2009; 125 (02) 362-366
    CrossrefPubMedGoogle Scholar
  • 8 Worden FP, Kumar B, Lee JS. et al. Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number. J Clin Oncol 2008; 26 (19) 3138-3146
    CrossrefPubMedGoogle Scholar
  • 9 Fakhry C, Westra WH, Li S. et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008; 100 (04) 261-269
    CrossrefPubMedGoogle Scholar
  • 10 Maxwell JH, Kumar B, Feng FY. et al. Tobacco use in HPV-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 2010; 16 (04) 1226
    CrossrefPubMedGoogle Scholar
  • 11 L DP. Shruti D. Diseases of Ear, Nose and Throat. 7th ed.. Elsevier India; 2017: 554
    Google Scholar
  • 12 Brugère JM, Mosseri VF, Mamelle G. et al. Nodal failures in patients with NO N+ oral squamous cell carcinoma without capsular rupture. Head Neck 1996; 18 (02) 133-137
    CrossrefPubMedGoogle Scholar
  • 13 Okamoto M, Nishimine M, Kishi M. et al. Prediction of delayed neck metastasis in patients with stage I/II squamous cell carcinoma of the tongue. J Oral Pathol Med 2002; 31 (04) 227-233
    CrossrefPubMedGoogle Scholar
  • 14 Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V. Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 2001; 63 (04) 202-207
    CrossrefPubMedGoogle Scholar
  • 15 Goodwin WJ. Distant metastases from oropharyngeal cancer. ORL J Otorhinolaryngol Relat Spec 2001; 63 (04) 222-223
    CrossrefPubMedGoogle Scholar
  • 16 Dobelbower MC, Nabell L, Markert J, Carroll W, Said-Al-Naief N, Meredith R. Cancer of the tonsil presenting as central nervous system metastasis: a case report. Head Neck 2009; 31 (01) 127-130
    CrossrefPubMedGoogle Scholar
  • 17 Cook MB, Dawsey SM, Freedman ND. et al. Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev 2009; 18 (04) 1174-1182
    CrossrefPubMedGoogle Scholar
  • 18 Golas SM. Trends in palatine tonsillar cancer incidence and mortality rates in the United States. Community Dent Oral Epidemiol 2007; 35 (02) 98-108
    CrossrefPubMedGoogle Scholar
  • 19 Charfi L, Jouffroy T, de Cremoux P. et al. Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome. Cancer Lett 2008; 260 (1-2): 72-78
    CrossrefPubMedGoogle Scholar
  • 20 D'Souza G, Kreimer AR, Viscidi R. et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356 (19) 1944-1956
    CrossrefPubMedGoogle Scholar
  • 21 Näsman A, Nordfors C, Holzhauser S. et al. Incidence of human papillomavirus positive tonsillar and base of tongue carcinoma: a stabilisation of an epidemic of viral induced carcinoma?. Eur J Cancer 2015; 51 (01) 55-61
    CrossrefPubMedGoogle Scholar
  • 22 Shimizu K, Inoue H, Saitoh M. et al. Distribution and impact of lymph node metastases in oropharyngeal cancer. Acta Otolaryngol 2006; 126 (08) 872-877
    CrossrefPubMedGoogle Scholar
  • 23 Ballantyne AJ, McCarten AB, Ibanez ML. The extension of cancer of the head and neck through peripheral nerves. Am J Surg 1963; 106: 651-667
    CrossrefPubMedGoogle Scholar
  • 24 Neumann E. Secundäre Cancroidinfiltration des Nervus mentalis bei einem Fall von Lippencancroid. BriefCommunication. Arch Pathol Anat Physiol Klin Med 1862; 24 (01) 201-202
    CrossrefPubMedGoogle Scholar
  • 25 Shattock SG. Invasion of the nerves in carcinoma of the sublingual salivary gland, associated with carcinoma of the tongue. Proc R Soc Med 1922; 15 (Pathol Sect): 13-16
    PubMedGoogle Scholar
  • 26 Ackerman LVDR, Juan A, Spjut JH, Ackerman LV. Ackerman and Del Regato's Cancer: Diagnosis, Treatment and Prognosis. 5th ed.. 1977. DOI: 10.1002/hed.2890050619
    CrossrefGoogle Scholar
  • 27 Bitoh S, Hasegawa H, Ohtsuki H, Obashi J, Kobayashi Y. Parasellar metastases: four autopsied cases. Surg Neurol 1985; 23 (01) 41-48
    CrossrefPubMedGoogle Scholar
  • 28 Dodd GD, Dolan PA, Ballantyne AJ, Ibanez ML, Chau P. The dissemination of tumors of the head and neck via the cranial nerves. Radiol Clin North Am 1970; 8 (03) 445-461
    CrossrefPubMedGoogle Scholar
  • 29 Cuneo HM, Rand CW. Tumors of the gasserian ganglion; tumor of the left gasserian ganglion associated with enlargement of the mandibular nerve; a review of the literature and case report. J Neurosurg 1952; 9 (05) 423-431
    CrossrefPubMedGoogle Scholar
  • 30 Trobe JD, Hood CI, Parsons JT, Quisling RG. Intracranial spread of squamous carcinoma along the trigeminal nerve. Arch Ophthalmol 1982; 100 (04) 608-611
    CrossrefPubMedGoogle Scholar
  • 31 Da Mosto MC, Zanetti F, Boscolo-Rizzo P. Pattern of lymph node metastases in squamous cell carcinoma of the tonsil: implication for selective neck dissection. Oral Oncol 2009; 45 (03) 212-217
    CrossrefPubMedGoogle Scholar
  • 32 Al-Khudari S, Guo S, Chen Y. et al. Solitary dural metastasis at presentation in a patient with untreated human papillomavirus-associated squamous cell carcinoma of the oropharynx. Head Neck 2014; 36 (10) E103-E105
    PubMedGoogle Scholar
  • 33 Banerjee S, Kundu D, Mukherjee M, Maiti PK. Early stage squamous cell carcinoma of the tonsil presenting with multiple organ metastases including skin and brain after successful local treatment. J Cancer Metastasis Treat 2015; DOI: 10.4103/2394-4722.152761.
    CrossrefPubMedGoogle Scholar
  • 34 practice Bb. Oropharyngeal cancer: treatment algorithm. BMJ Best Practice. BMJ. Accessed March 3, 2019 at: https://bestpractice.bmj.com/topics/en-gb/1114/treatmentalgorithm
    PubMedGoogle Scholar