Semin Neurol
DOI: 10.1055/s-0041-1726285
Review Article

Neurological Complications in Patients with Heart Transplantation

Amra Sakusic
1  Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida
2  Multidisciplinary Epidemiology and Translational Research in Intensive Care, Emergency and Perioperative Medicine (METRIC), Mayo Clinic, Rochester, Minnesota
Alejandro A. Rabinstein
3  Department of Neurology, Mayo Clinic, Rochester, Minnesota
› Author Affiliations


Neurological complications after heart transplantation are common and include cerebrovascular events (ischemic strokes, hemorrhagic strokes, and transient ischemic attacks), seizures, encephalopathy, central nervous system (CNS) infections, malignancies, and peripheral nervous system complications. Although most neurological complications are transient, strokes and CNS infections can result in high mortality and morbidity. Early recognition and timely management of these serious complications are crucial to improve survival and recovery. Diagnosing CNS infections can be challenging because their clinical presentation can be subtle in the setting of immunosuppression. Immunosuppressive medications themselves can cause a broad spectrum of neurological complications including seizures and posterior reversible encephalopathy syndrome. This article provides a review of the diagnosis and management of neurological complications after cardiac transplantation.

Publication History

Publication Date:
13 April 2021 (online)

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