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CC BY-NC-ND 4.0 · South Asian J Cancer 2020; 09(04): 250-252
DOI: 10.1055/s-0041-1726138
Original Article: Supportive and Palliative Care

An Ayurveda Gargle Regimen in Management of Radiotherapy-induced Oral Mucositis

Pankaj Wanjarkhedkar 
1   Department of Ayurveda and Integrative Medicine, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Sonali Pingley
2   Department of Radiation Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Shaileshkumar Shende
2   Department of Radiation Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Dhananjay Kelkar
3   Department of Surgical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Amit Parasnis
3   Department of Surgical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Mahesh Sambhus
3   Department of Surgical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Girish Phadake
3   Department of Surgical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Sachin Hingmire
4   Department of Medical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Padmaj Kulkarni
4   Department of Medical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
,
Chetan Deshmukh
4   Department of Medical Oncology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
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Abstract

Background Radiotherapy-induced oral mucositis (RIOM) in patients with head and neck cancer may lead to significant morbidity. OM may result in erythema, ulceration, and pseudomembrane formation. The usual time of onset is second or third week of radiotherapy (RT), after the doses of 16 to 18 Gy. OM may cause severe pain, significant weight loss, increased resource use, interruption or discontinuation of the treatment, and added cost of supportive care.

Materials and Methods Patients who underwent RT and chemoradiation (CTRT) for head and neck squamous cell carcinoma (HNSCC) from 2015 to 2016 were included. The patients who were treated with the add-on Ayurveda gargle regimen (AGR) of sapthachhadadi gandoosham were evaluated against patients treated with standard symptomatic care (SSC).

Statistical Analysis Chi-square test was used to compare the difference between the two groups in the present study with SPSS (SPSS version 20 for Windows package SPSS Science, Chicago, IL, USA). software.

Result Grade III to IV OM was lower in the AGR group when compared with the SSC group (p < 0.001). Onset of OM was significantly delayed in patients from the AGR group (p < 0.001).

Conclusion The AGR with sapthachhadadi gandoosham is effective in delaying the onset and reducing severity of OM in HNSCC, without compromising the rate of locoregional recurrence.

Keywords

oral mucositis - Ayurveda gargle regimen - sapthachhadadi gandoosham

Supplementary Figure



Publikationsverlauf

Artikel online veröffentlicht:
15. Juni 2021

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