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Polymorphisms of the Vitamin D Receptor Gene in Crohn’s DiseasePolimorfismos do gene do receptor de vitamina D na doença de Crohn
Introduction Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions of the gastrointestinal tract. Studies have shown that polymorphisms of the vitamin D receptor (VDR) gene may help elucidate the pathogenesis of CD.
Objectives To analyze the role of VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) in the development of CD.
Methods The present study is a systematic review with meta-analysis. a total of 50 articles in English and Portuguese published from 2000 to 2020 were selected from 3 databases. The relationship between CD and the VDR gene was addressed in 16 articles.
Results The TaqI polymorphism was analyzed in 3,689 patients and 4,645 control subjects (odds ratio [OR] = 0.948; 95% confidence interval [95%CI] = 0.851–1.056; p = 0.3467). The ApaI polymorphism was studied in 3,406 patients and 4,415 control subjects (OR = 1,033; 95%CI = 0.854–1.250; p = 0.7356). For FokI polymorphism, there were 2,998 patients and 4,146 control subjects (OR = 0.965; 95%CI = 0.734–1.267; p = 0.7958). Lastly, the BsmI polymorphism was analyzed in 2,981 patients and 4,477 control subjects (OR = 1,272; 95%CI = 0.748–2.161; p = 0.3743).
Conclusion These four VDR gene polymorphisms were not associated with CD. Therefore, further studies with larger samples are required to corroborate or rectify the conclusions from the present meta-analysis.
Introdução A doença de Crohn (DC) e a retocolite ulcerativa (RU) são condições inflamatórias crônicas do trato gastrointestinal. Estudos indicam que os polimorfismos do gene do receptor de vitamina D (RVD) são promissores para a patogênese da DC.
Objetivos Avaliar papel dos os polimorfismos do gene do RVD (ApaI, BsmI, FokI e TaqI) no desenvolvimento da DC.
Métodos Trata-se de uma revisão sistemática com metanálise. Foram identificados 50 artigos em inglês e português publicados entre 2000 a 2020 em 3 bases de dados. Destes, foram selecionados 16 artigos que contemplavam a relação entre a DC e o gene do RVD.
Resultados Para o polimorfismo TaqI, a amostra foi composta por 3.689 pacientes e 4.645 controles (razão de probabilidade [RP] = 0,948; intervalo de confiança de 95% [IC95%] = 0,851–1,056; p = 0,3467). Para o polimorfismo ApaI, 3.406 pacientes e 4.415 controles (RP = 1,033; IC95% = 0,854–1,250; p = 0,7356). Para o polimorfismo FokI, 2.998 pacientes e 4.146 controles (RP = 0,965; IC95% = 0,734–1,267; p = 0,7958). E, para o polimorfismo BsmI, 2.981 pacientes e 4.477 controles (RP = 1,272; IC95% = 0,748–2,161; p = 0,3743).
Conclusão Esses quatro polimorfismos do gene do RVD não apresentaram associação com a DC. Logo, sugere-se a realização de mais estudos com amostras maiores a fim de corroborar ou retificar a conclusão desta metanálise.
Received: 10 August 2020
Accepted: 07 September 2020
24 May 2021 (online)
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