Int J Angiol
DOI: 10.1055/s-0041-1725979
Review Article

Pathophysiology, Diagnosis, and Management of Coronary No-Reflow Phenomenon

Gagan Kaur
1  University of California, Riverside School of Medicine, Riverside, California
,
Patrick Baghdasaryan
1  University of California, Riverside School of Medicine, Riverside, California
,
Balaji Natarajan
1  University of California, Riverside School of Medicine, Riverside, California
,
Prabhdeep Sethi
1  University of California, Riverside School of Medicine, Riverside, California
,
Ashis Mukherjee
1  University of California, Riverside School of Medicine, Riverside, California
,
Padmini Varadarajan
1  University of California, Riverside School of Medicine, Riverside, California
,
1  University of California, Riverside School of Medicine, Riverside, California
› Author Affiliations
Funding None.

Abstract

Coronary no-reflow phenomenon is a lethal mechanism of ongoing myocardial injury, following successful revascularization of an infarct-related coronary artery. Incidence of this phenomenon is high following percutaneous intervention, and is associated with adverse in-hospital and long-term outcomes. Several mechanisms such as ischemia-reperfusion injury and distal microthromboembolism in genetically susceptible patients and those with preexisting endothelial dysfunction have been implicated. However, the exact mechanism in humans is still poorly understood. Several investigative and treatment strategies within and outside the cardiac catheterization laboratory have been proposed, but have not uniformly shown success in reducing mortality or in preventing adverse left ventricular remodeling resulting from this condition. The aim of this article is to provide a brief and concise review of the current understanding of the pathophysiology, clinical predictors, and investigations and management of coronary no-reflow phenomenon.



Publication History

Publication Date:
03 March 2021 (online)

© 2021. International College of Angiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA