Abstract
The novel coronavirus disease 2019 (COVID-19) that started to invade the world from
the Chinese fish market, causes an acute respiratory distress syndrome. COVID-19 is
a dreadful infectious disease that surfaced only less than 8 months ago and caused
the deadly COVID-19 pandemic. In this new species with a positive, single-strand RNA
genome and a huge size, from the proteomics point view, there are no changes in sequences
of amino acids in NSP7, 13, matrix, or envelope or other proteins including 8b and
p6 and excluding NSP2 and NSP3. P6 is a multifunctional golgi–endoplasmic reticulum
membrane-associated protein. This complex has a key duty to increase the replication
rate of the virus and also causes intrinsic immune system responses by suppressing
the signal transducer and activator of transcription factor 1 (STAT 1) translocated
to the nucleus. Palmitoylated proteins elevate hydrophobicity which helps in membrane
connection. Inside the N-linked glycosylation, moieties oligosaccharide is adhering
to Asn-X-Ser/Thr canonical sequence. This helps for exact enfolding and carrying viral
proteins by industriously using host's chaperon proteins including calreticulin and
calnexin. 2B proteins encourage the internalization of major histocompatibility complex,
class-I (MHC-I) protein and meanwhile inhibit their transfer to the surface of the
cell as a recognition side. The deubiquitination of severe acute respiratory syndrome-coronavirus-2
(SARS-CoV-2) has precise modification apparatus in the posttranslational stage. In
this article, we outlined the recent and up-to-date data on genomic and molecular
structures, epidemiology, vaccine development, and, last but not least, the clinical
features, diagnostics, and treatment of the novel coronavirus.
Keywords
coronavirus - COVID-19 - pandemic - viral outbreak - genomics of virus
