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Semin Neurol 2021; 41(02): 177-188
DOI: 10.1055/s-0041-1725139
Review Article

Retention of Physical Gains in the Community Following Physical Training for Multiple Sclerosis: A Systematic Review and Implications

Victor W. Mark
1   Departments of Physical Medicine and Rehabilitation, Neurology, and Psychology, University of Alabama at Birmingham, Birmingham, Alabama
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Abstract

Multiple sclerosis (MS) is a progressive neurological illness whose typically young adult onset results in a nearly entire lifetime of worsening disability. But despite being an unrelenting neurodegenerative disease, numerous clinical trials over the past 40 years for MS have vigorously attempted to improve or at least stabilize declining physical function. Although the vast majority of the studies assessed training effects only within controlled laboratory or clinic settings, in recent years a growing interest has emerged to test whether newer therapies can instead benefit real-life activities in the community. Nonetheless, comparatively little attention has been paid to whether the training gains can be retained for meaningful periods. This review discusses the comparative success of various physical training methods to benefit within-community activities in MS, and whether the gains can be retained long afterward. This review will suggest future research directions toward establishing efficacious treatments that can allow persons with MS to reclaim their physical abilities and maximize functionality for meaningful periods.

Keywords

multiple sclerosis - rehabilitation - recovery - assessment - physical therapy


Publikationsverlauf

Artikel online veröffentlicht:
09. März 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R. How common are the “common” neurologic disorders?. Neurology 2007; 68 (05) 326-337
    CrossrefPubMedGoogle Scholar
  • 2 Peterson JW, Trapp BD. Neuropathobiology of multiple sclerosis. Neurol Clin 2005; 23 (01) 107-129 , vi–vii
    CrossrefPubMedGoogle Scholar
  • 3 Browne P, Chandraratna D, Angood C. et al. Atlas of Multiple Sclerosis 2013: a growing global problem with widespread inequity. Neurology 2014; 83 (11) 1022-1024
    CrossrefPubMedGoogle Scholar
  • 4 Wootla B, Watzlawik JO, Stavropoulos N. et al. Recent advances in monoclonal antibody therapies for multiple sclerosis. Expert Opin Biol Ther 2016; 16 (06) 827-839
    CrossrefPubMedGoogle Scholar
  • 5 Wingerchuk DM, Carter JL. Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies. Mayo Clin Proc 2014; 89 (02) 225-240
    CrossrefPubMedGoogle Scholar
  • 6 Kraft GH. Rehabilitation still the only way to improve function in multiple sclerosis. Lancet 1999; 354 (9195): 2016-2017
    CrossrefPubMedGoogle Scholar
  • 7 Ploughman M. A new era of multiple sclerosis rehabilitation: lessons from stroke. Lancet Neurol 2017; 16 (10) 768-769
    CrossrefPubMedGoogle Scholar
  • 8 Cree BAC, Hollenbach JA, Bove R. et al; University of California, San Francisco MS-EPIC Team. Silent progression in disease activity-free relapsing multiple sclerosis. Ann Neurol 2019; 85 (05) 653-666
    CrossrefPubMedGoogle Scholar
  • 9 Finlayson M, Plow M, Cho C. Use of physical therapy services among middle-aged and older adults with multiple sclerosis. Phys Ther 2010; 90 (11) 1607-1618
    CrossrefPubMedGoogle Scholar
  • 10 Rietberg MB, Brooks D, Uitdehaag BMJ, Kwakkel G. Exercise therapy for multiple sclerosis. Cochrane Database Syst Rev 2005; (01) CD003980
    PubMedGoogle Scholar
  • 11 Frau J, Coghe G, Lorefice L. et al. Attitude towards physical activity in patients with multiple sclerosis: a cohort study. Neurol Sci 2015; 36 (06) 889-893
    CrossrefPubMedGoogle Scholar
  • 12 Yadav V, Shinto L, Morris C, Senders A, Baldauf-Wagner S, Bourdette D. Use and self-reported benefit of complementary and alternative medicine among multiple sclerosis patients. Int J MS Care 1999; 8: 5-10
    CrossrefPubMedGoogle Scholar
  • 13 Maker-Clark G, Patel S. Integrative therapies for multiple sclerosis. Dis Mon 2013; 59 (08) 290-301
    CrossrefPubMedGoogle Scholar
  • 14 Claflin SB, van der Mei IAF, Taylor BV. Complementary and alternative treatments of multiple sclerosis: a review of the evidence from 2001 to 2016. J Neurol Neurosurg Psychiatry 2018; 89 (01) 34-41
    CrossrefPubMedGoogle Scholar
  • 15 Halabchi F, Alizadeh Z, Sahraian MA, Abolhasani M. Exercise prescription for patients with multiple sclerosis; potential benefits and practical recommendations. BMC Neurol 2017; 17 (01) 185
    CrossrefPubMedGoogle Scholar
  • 16 Baird JF, Sandroff BM, Motl RW. Therapies for mobility disability in persons with multiple sclerosis. Expert Rev Neurother 2018; 18 (06) 493-502
    CrossrefPubMedGoogle Scholar
  • 17 Pilutti LA, Hicks AL. Rehabilitation of ambulatory limitations. Phys Med Rehabil Clin N Am 2013; 24 (02) 277-290
    CrossrefPubMedGoogle Scholar
  • 18 Latimer-Cheung AE, Pilutti LA, Hicks AL. et al. Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development. Arch Phys Med Rehabil 2013; 94 (09) 1800.e3-1828.e3
    PubMedGoogle Scholar
  • 19 Sasaki JE, Motl RW, Cutter G, Marrie RA, Tyry T, Salter A. National estimates of self-reported sitting time in adults with multiple sclerosis. Mult Scler J Exp Transl Clin 2018; 4 (01) 2055217318754368
    CrossrefPubMedGoogle Scholar
  • 20 Pike J, Jones E, Rajagopalan K, Piercy J, Anderson P. Social and economic burden of walking and mobility problems in multiple sclerosis. BMC Neurol 2012; 12: 94
    CrossrefPubMedGoogle Scholar
  • 21 Larocca NG. Impact of walking impairment in multiple sclerosis: perspectives of patients and care partners. Patient 2011; 4 (03) 189-201
    CrossrefPubMedGoogle Scholar
  • 22 Heesen C, Böhm J, Reich C, Kasper J, Goebel M, Gold SM. Patient perception of bodily functions in multiple sclerosis: gait and visual function are the most valuable. Mult Scler 2008; 14 (07) 988-991
    CrossrefPubMedGoogle Scholar
  • 23 Scheinberg L, Holland N, Larocca N, Laitin P, Bennett A, Hall H. Multiple sclerosis; earning a living. N Y State J Med 1980; 80 (09) 1395-1400
    PubMedGoogle Scholar
  • 24 Einarsson U, Gottberg K, Fredrikson S, von Koch L, Holmqvist LW. Activities of daily living and social activities in people with multiple sclerosis in Stockholm County. Clin Rehabil 2006; 20 (06) 543-551
    CrossrefPubMedGoogle Scholar
  • 25 Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Lancet Physical Activity Series Working Group. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012; 380 (9838): 219-229
    CrossrefPubMedGoogle Scholar
  • 26 Ding D, Lawson KD, Kolbe-Alexander TL. et al; Lancet Physical Activity Series 2 Executive Committee. The economic burden of physical inactivity: a global analysis of major non-communicable diseases. Lancet 2016; 388 (10051): 1311-1324
    CrossrefPubMedGoogle Scholar
  • 27 Morris KS, McAuley E, Motl RW. Self-efficacy and environmental correlates of physical activity among older women and women with multiple sclerosis. Health Educ Res 2008; 23 (04) 744-752
    CrossrefPubMedGoogle Scholar
  • 28 Shnek ZM, Foley FW, LaRocca NG. et al. Helplessness, self-efficacy, cognitive distortions, and depression in multiple sclerosis and spinal cord injury. Ann Behav Med 1997; 19 (03) 287-294
    CrossrefPubMedGoogle Scholar
  • 29 Mertin J. Rehabilitation in multiple sclerosis. Ann Neurol 1994; 36 (Suppl): S130-S133
    CrossrefPubMedGoogle Scholar
  • 30 Noseworthy JH. Clinical scoring methods for multiple sclerosis. Ann Neurol 1994; 36 (Suppl): S80-S85
    CrossrefPubMedGoogle Scholar
  • 31 Freeman JA, Langdon DW, Hobart JC, Thompson AJ. Inpatient rehabilitation in multiple sclerosis: do the benefits carry over into the community?. Neurology 1999; 52 (01) 50-56
    CrossrefPubMedGoogle Scholar
  • 32 Petajan JH, White AT. Recommendations for physical activity in patients with multiple sclerosis. Sports Med 1999; 27 (03) 179-191
    CrossrefPubMedGoogle Scholar
  • 33 Dalgas U, Stenager E, Ingemann-Hansen T. Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training. Mult Scler 2008; 14 (01) 35-53
    CrossrefPubMedGoogle Scholar
  • 34 Bever CT, Judge SI. Sustained-release fampridine for multiple sclerosis. Expert Opin Investig Drugs 2009; 18 (07) 1013-1024
    CrossrefPubMedGoogle Scholar
  • 35 Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33 (11) 1444-1452
    CrossrefPubMedGoogle Scholar
  • 36 Block VJ, Lizée A, Crabtree-Hartman E. et al. Continuous daily assessment of multiple sclerosis disability using remote step count monitoring. J Neurol 2017; 264 (02) 316-326
    CrossrefPubMedGoogle Scholar
  • 37 Engelhard MM, Patek SD, Lach JC, Goldman MD. Real-world walking in multiple sclerosis: Separating capacity from behavior. Gait Posture 2018; 59: 211-216
    CrossrefPubMedGoogle Scholar
  • 38 Plummer P, Anderson J, Stewart A. On the importance of gait speed: perspectives from people with multiple sclerosis and neurologic physical therapists. Int J MS Care 2019; 21 (Suppl. 01) 97
    PubMedGoogle Scholar
  • 39 Nowinski CJ, Miller DM, Cella D. Evolution of patient-reported outcomes and their role in multiple sclerosis clinical trials. Neurotherapeutics 2017; 14 (04) 934-944
    CrossrefPubMedGoogle Scholar
  • 40 Sims RV, McGwin Jr G, Pulley LV, Roseman JM. Mobility impairments in crash-involved older drivers. J Aging Health 2001; 13 (03) 430-438
    CrossrefPubMedGoogle Scholar
  • 41 Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale NJ: Lawrence Erlbaum; 1988
    Google Scholar
  • 42 Hobart JC, Riazi A, Lamping DL, Fitzpatrick R, Thompson AJ. Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12). Neurology 2003; 60 (01) 31-36
    CrossrefPubMedGoogle Scholar
  • 43 Freeman JA, Gear M, Pauli A. et al. The effect of core stability training on balance and mobility in ambulant individuals with multiple sclerosis: a multi-centre series of single case studies. Mult Scler 2010; 16 (11) 1377-1384
    CrossrefPubMedGoogle Scholar
  • 44 Feys P, Tytgat K, Gijbels D, De Groote L, Baert I, Van Asch P. Effects of an 1-day education program on physical functioning, activity and quality of life in community living persons with multiple sclerosis. NeuroRehabilitation 2013; 33 (03) 439-448
    CrossrefPubMedGoogle Scholar
  • 45 Downing A, Van Ryn D, Fecko A. et al. Effect of a 2-week trial of functional electrical stimulation on gait function and quality of life in people with multiple sclerosis. Int J MS Care 2014; 16 (03) 146-152
    CrossrefPubMedGoogle Scholar
  • 46 Mandelbaum R, Triche EW, Fasoli SE, Lo A. The effects of salsa dance on gait and balance in multiple sclerosis. Neurology 2014; 82: P3.053
    PubMedGoogle Scholar
  • 47 Mandelbaum R, Triche EW, Fasoli SE, Lo AC. A pilot study: examining the effects and tolerability of structured dance intervention for individuals with multiple sclerosis. Disabil Rehabil 2016; 38 (03) 218-222
    CrossrefPubMedGoogle Scholar
  • 48 Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J 1965; 14 (02) 61-65
    PubMedGoogle Scholar
  • 49 Gresham GE, Phillips TF, Labi MLC. ADL status in stroke: relative merits of three standard indexes. Arch Phys Med Rehabil 1980; 61 (08) 355-358
    PubMedGoogle Scholar
  • 50 Roy CW, Togneri J, Hay E, Pentland B. An inter-rater reliability study of the Barthel Index. Int J Rehabil Res 1988; 11: 67-70
    CrossrefPubMedGoogle Scholar
  • 51 Taub E, Miller NE, Novack TA. et al. Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 1993; 74 (04) 347-354
    PubMedGoogle Scholar
  • 52 Craig CL, Marshall AL, Sjöström M. et al. International Physical Activity Questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35 (08) 1381-1395
    CrossrefPubMedGoogle Scholar
  • 53 Godin G, Shephard RJ. Godin Leisure-Time Exercise Questionnaire. Med Sci Sports Exerc 1997; 29 (Suppl. 06) S36-S38
    PubMedGoogle Scholar
  • 54 Baecke JAH, Burema J, Frijters JER. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982; 36 (05) 936-942
    CrossrefPubMedGoogle Scholar
  • 55 Straudi S, Martinuzzi C, Pavarelli C. et al. A task-oriented circuit training in multiple sclerosis: a feasibility study. BMC Neurol 2014; 14: 124
    CrossrefPubMedGoogle Scholar
  • 56 Kjølhede T, Vissing K, de Place L. et al. Neuromuscular adaptations to long-term progressive resistance training translates to improved functional capacity for people with multiple sclerosis and is maintained at follow-up. Mult Scler 2015; 21 (05) 599-611
    CrossrefPubMedGoogle Scholar
  • 57 Fox EE, Hough AD, Creanor S, Gear M, Freeman JA. Effects of Pilates-based core stability training in ambulant people with multiple sclerosis: multicenter, assessor-blinded, randomized controlled trial. Phys Ther 2016; 96 (08) 1170-1178
    CrossrefPubMedGoogle Scholar
  • 58 Hayes S, Uszynski MK, Motl RW. et al. Randomised controlled pilot trial of an exercise plus behaviour change intervention in people with multiple sclerosis: the Step it Up study. BMJ Open 2017; 7 (10) e016336
    CrossrefPubMedGoogle Scholar
  • 59 Tavazzi E, Bergsland N, Cattaneo D. et al. Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study. J Neurol 2018; 265 (06) 1393-1401
    CrossrefPubMedGoogle Scholar
  • 60 Martini DN, Zeeboer E, Hildebrand A, Fling BW, Hugos CL, Cameron MH. ADSTEP: preliminary investigation of a multicomponent walking aid program in people with multiple sclerosis. Arch Phys Med Rehabil 2018; 99 (10) 2050-2058
    CrossrefPubMedGoogle Scholar
  • 61 Dlugonski D, Motl RW, Mohr DC, Sandroff BM. Internet-delivered behavioral intervention to increase physical activity in persons with multiple sclerosis: sustainability and secondary outcomes. Psychol Health Med 2012; 17 (06) 636-651
    CrossrefPubMedGoogle Scholar
  • 62 Carter A, Daley A, Humphreys L. et al. Pragmatic intervention for increasing self-directed exercise behaviour and improving important health outcomes in people with multiple sclerosis: a randomised controlled trial. Mult Scler 2014; 20 (08) 1112-1122
    CrossrefPubMedGoogle Scholar
  • 63 Vaney C, Gattlen B, Lugon-Moulin V. et al. Robotic-assisted step training (lokomat) not superior to equal intensity of over-ground rehabilitation in patients with multiple sclerosis. Neurorehabil Neural Repair 2012; 26 (03) 212-221
    CrossrefPubMedGoogle Scholar
  • 64 Craig J, Young CA, Ennis M, Baker G, Boggild M. A randomised controlled trial comparing rehabilitation against standard therapy in multiple sclerosis patients receiving intravenous steroid treatment. J Neurol Neurosurg Psychiatry 2003; 74 (09) 1225-1230
    CrossrefPubMedGoogle Scholar
  • 65 Collett J, Dawes H, Meaney A. et al. Exercise for multiple sclerosis: a single-blind randomized trial comparing three exercise intensities. Mult Scler 2011; 17 (05) 594-603
    CrossrefPubMedGoogle Scholar
  • 66 Mark VW, Taub E, Bashir K. et al. Constraint-induced movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings. Mult Scler 2008; 14 (07) 992-994
    CrossrefPubMedGoogle Scholar
  • 67 Mark VW, Taub E, Uswatte G. et al. Phase II randomized controlled trial of constraint-induced movement therapy in multiple sclerosis. Part 1: effects on real-world function. Neurorehabil Neural Repair 2018; 32 (03) 223-232
    CrossrefPubMedGoogle Scholar
  • 68 Mehta L, McNeill M, Hobart J. et al. Identifying an important change estimate for the Multiple Sclerosis Walking Scale-12 (MSWS-12v1) for interpreting clinical trial results. Mult Scler J Exp Transl Clin 2015; 1: 2055217315596993
    CrossrefPubMedGoogle Scholar
  • 69 Hsieh YW, Wang CH, Wu SC, Chen PC, Sheu CF, Hsieh CL. Establishing the minimal clinically important difference of the Barthel Index in stroke patients. Neurorehabil Neural Repair 2007; 21 (03) 233-238
    CrossrefPubMedGoogle Scholar
  • 70 Lang CE, Edwards DF, Birkenmeier RL, Dromerick AW. Estimating minimal clinically important differences of upper-extremity measures early after stroke. Arch Phys Med Rehabil 2008; 89 (09) 1693-1700
    CrossrefPubMedGoogle Scholar
  • 71 Ingram G, Colley E, Ben-Shlomo Y. et al. Validity of patient-derived disability and clinical data in multiple sclerosis. Mult Scler 2010; 16 (04) 472-479
    CrossrefPubMedGoogle Scholar
  • 72 Mark VW, Taub E, Cutter GR. et al. The measurement of upper extremity learned nonuse in multiple sclerosis. Int J MS Care 2010; 12 (Suppl. 01) 49
    PubMedGoogle Scholar
  • 73 Taub E, Uswatte G, Pidikiti R. Constraint-induced movement therapy: a new family of techniques with broad application to physical rehabilitation--a clinical review. J Rehabil Res Dev 1999; 36 (03) 237-251
    PubMedGoogle Scholar
  • 74 Collins ME, Mark VW, Taub E, Uswatte G, McKay S, D'Andrea Lee R. Validating a community-based measure of leg use for multiple sclerosis. Int J MS Care 2014; 16: 82-83
    PubMedGoogle Scholar
  • 75 Bandura A. Health promotion by social cognitive means. Health Educ Behav 2004; 31 (02) 143-164
    CrossrefPubMedGoogle Scholar
  • 76 Taub E. Somatosensory deafferentation research with monkeys: implications for rehabilitation medicine. In: Ince LP. ed. Behavioral Psychology in Rehabilitation Medicine: Clinical Applications. Baltimore, MD: Williams and Wilkins, 1980; 371-401
    Google Scholar
  • 77 Wolf SL, Winstein CJ, Miller JP. et al; EXCITE Investigators. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA 2006; 296 (17) 2095-2104
    CrossrefPubMedGoogle Scholar
  • 78 Shaw SE, Morris DM, Uswatte G, McKay S, Meythaler JM, Taub E. Constraint-induced movement therapy for recovery of upper-limb function following traumatic brain injury. J Rehabil Res Dev 2005; 42 (06) 769-778
    CrossrefPubMedGoogle Scholar
  • 79 Taub E, Ramey SL, DeLuca S, Echols K. Efficacy of constraint-induced movement therapy for children with cerebral palsy with asymmetric motor impairment. Pediatrics 2004; 113 (02) 305-312
    CrossrefPubMedGoogle Scholar
  • 80 Morris DM, Taub E, Mark VW. Constraint-induced movement therapy: characterizing the intervention protocol. Eura Medicophys 2006; 42 (03) 257-268
    PubMedGoogle Scholar
  • 81 Uswatte G, Taub E, Morris D, Light K, Thompson PA. The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke. Neurology 2006; 67 (07) 1189-1194
    CrossrefPubMedGoogle Scholar
  • 82 Barghi A, Allendorfer JB, Taub E. et al. Phase II randomized controlled trial of constraint-induced movement therapy in multiple sclerosis. Part 2: effect on white matter integrity. Neurorehabil Neural Repair 2018; 32 (03) 233-241
    CrossrefPubMedGoogle Scholar
  • 83 Prosperini L, Piattella MC, Giannì C, Pantano P. Functional and structural brain plasticity enhanced by motor and cognitive rehabilitation in multiple sclerosis. Neural Plast 2015; 2015: 481574
    CrossrefPubMedGoogle Scholar
  • 84 Grussu F, Schneider T, Tur C. et al. Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?. Ann Clin Transl Neurol 2017; 4 (09) 663-679
    CrossrefPubMedGoogle Scholar
  • 85 Spanò B, Giulietti G, Pisani V. et al. Disruption of neurite morphology parallels MS progression. Neurol Neuroimmunol Neuroinflamm 2018; 5 (06) e502
    CrossrefPubMedGoogle Scholar
  • 86 Alarcón F, Zijlmans JCM, Dueñas G, Cevallos N. Post-stroke movement disorders: report of 56 patients. J Neurol Neurosurg Psychiatry 2004; 75 (11) 1568-1574
    CrossrefPubMedGoogle Scholar
  • 87 Jespersen SN, Bjarkam CR, Nyengaard JR. et al. Neurite density from magnetic resonance diffusion measurements at ultrahigh field: comparison with light microscopy and electron microscopy. Neuroimage 2010; 49 (01) 205-216
    CrossrefPubMedGoogle Scholar
  • 88 Mark VW, Taub E, Uswatte G. et al. Constraint-induced movement therapy for the lower extremities in multiple sclerosis: case series with 4-year follow-up. Arch Phys Med Rehabil 2013; 94 (04) 753-760
    CrossrefPubMedGoogle Scholar
  • 89 Mark VW, Taub E, Uswatte G, Morris DM, Bowman MH, McKay S. Unprecedented long-term retention of motor community gains following Constraint-Induced Movement therapy for MS. Int J MS Care 2019; 21 (Suppl. 01) 90
    PubMedGoogle Scholar
  • 90 Taub E, Uswatte G, King DK, Morris D, Crago JE, Chatterjee A. A placebo-controlled trial of constraint-induced movement therapy for upper extremity after stroke. Stroke 2006; 37 (04) 1045-1049
    CrossrefPubMedGoogle Scholar
  • 91 Taub E, Uswatte G, Mark VW. et al. Method for enhancing real-world use of a more affected arm in chronic stroke: transfer package of constraint-induced movement therapy. Stroke 2013; 44 (05) 1383-1388
    CrossrefPubMedGoogle Scholar
  • 92 Uswatte G, Taub E, Morris D, Barman J, Crago J. Contribution of the shaping and restraint components of Constraint-Induced Movement therapy to treatment outcome. NeuroRehabilitation 2006; 21 (02) 147-156
    CrossrefPubMedGoogle Scholar
  • 93 Takebayashi T, Amano S, Hanada K. et al. A one-year follow-up after modified constraint-induced movement therapy for chronic stroke patients with paretic arm: a prospective case series study. Top Stroke Rehabil 2015; 22 (01) 18-25
    CrossrefPubMedGoogle Scholar
  • 94 Martinková P, Freeman J, Drabinová A. et al. Physiotherapeutic interventions in multiple sclerosis across Europe: regions and other factors that matter. Mult Scler Relat Disord 2018; 22: 59-67
    CrossrefPubMedGoogle Scholar
  • 95 Tur C, Moccia M, Barkhof F. et al. Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting. Nat Rev Neurol 2018; 14 (02) 75-93
    CrossrefPubMedGoogle Scholar
  • 96 Block VJ, Bove R, Zhao C. et al. Association of continuous assessment of step count by remote monitoring with disability progression among adults with multiple sclerosis. JAMA Netw Open 2019; 2 (03) e190570
    CrossrefPubMedGoogle Scholar
  • 97 Nazareth TA, Rava AR, Polyakov JL. et al. Relapse prevalence, symptoms, and health care engagement: patient insights from the Multiple Sclerosis in America 2017 survey. Mult Scler Relat Disord 2018; 26: 219-234
    CrossrefPubMedGoogle Scholar
  • 98 Blight AR. Treatment of walking impairment in multiple sclerosis with dalfampridine. Ther Adv Neurol Disorder 2011; 4 (02) 99-109
    CrossrefPubMedGoogle Scholar
  • 99 Crayton H, Sidovar M, Wulf S, Guo A. Patient perspectives and experience with dalfampridine treatment in multiple sclerosis-related walking impairment: the step together program. Patient 2015; 8 (03) 283-291
    CrossrefPubMedGoogle Scholar
  • 100 Zörner B, Filli L, Reuter K. et al. Prolonged-release fampridine in multiple sclerosis: Improved ambulation effected by changes in walking pattern. Mult Scler 2016; 22 (11) 1463-1475
    CrossrefPubMedGoogle Scholar
  • 101 Sagawa Y, Watelain E, Moulin T, Decavel P. No effect of fampridine on real-life physical activity in people with multiple sclerosis. Ann Phys Rehabil Med 2018; 61 (02) 105-107
    CrossrefPubMedGoogle Scholar
  • 102 Kjølhede T, Siemonsen S, Wenzel D. et al. Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?. Mult Scler 2018; 24 (10) 1356-1365
    CrossrefPubMedGoogle Scholar
  • 103 Feys P, Moumdjian L, Van Halewyck F. et al. Effects of an individual 12-week community-located “start-to-run” program on physical capacity, walking, fatigue, cognitive function, brain volumes, and structures in persons with multiple sclerosis. Mult Scler 2019; 25 (01) 92-103
    CrossrefPubMedGoogle Scholar
  • 104 Gauthier LV, Taub E, Perkins CE, Ortmann M, Mark VW, Uswatte G. Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke. Stroke 2008; 39 (05) 1520-1525
    CrossrefPubMedGoogle Scholar
  • 105 Sterling C, Taub E, Davis D. et al. Structural neuroplastic change after constraint-induced movement therapy in children with cerebral palsy. Pediatrics 2013; 131 (05) e1664-e1669
    CrossrefPubMedGoogle Scholar
  • 106 Filippi M, Rocca MA. MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system. J Neurol 2005; 252 (Suppl. 05) v16-v24
    CrossrefPubMedGoogle Scholar