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Semin Neurol 2021; 41(02): 147-156
DOI: 10.1055/s-0041-1725136
Review Article

Learning and Stroke Recovery: Parallelism of Biological Substrates

Mary Teena Joy
1   Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California
,
S. Thomas Carmichael 
1   Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California
› Institutsangaben Funding Supported by the Dr. Miriam and Sheldon G Adelson Medical Research Foundation, NIIH grants NS102185 and NS085019.
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Abstract

Stroke is a debilitating disease. Current effective therapies for stroke recovery are limited to neurorehabilitation. Most stroke recovery occurs in a limited and early time window. Many of the mechanisms of spontaneous recovery after stroke parallel mechanisms of normal learning and memory. While various efforts are in place to identify potential drug targets, an emerging approach is to understand biological correlates between learning and stroke recovery. This review assesses parallels between biological changes at the molecular, structural, and functional levels during learning and recovery after stroke, with a focus on drug and cellular targets for therapeutics.

Keywords

stroke - learning and memory - neurorehabilitation - dendritic spines - axonal sprouting - molecular systems - cortical maps - functional motor recovery


Publikationsverlauf

Artikel online veröffentlicht:
09. März 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
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