Semin Thromb Hemost 2021; 47(05): 480-489
DOI: 10.1055/s-0041-1725094
Review Article

Fibrinolysis in Venous Thromboembolism

Anetta Undas
1  Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
2  Krakow Centre for Medical Research and Technologies, John Paul II Hospital, Krakow, Poland
› Author Affiliations
Funding The study was supported by a grant of Jagiellonian University Medical College (N41/DBS/000184).


Fibrinolysis is of paramount importance in maintaining or regaining the patency of veins and pulmonary arteries obstructed by thrombi. Growing experimental and clinical evidence indicates that impaired fibrinolysis mediated by multiple complex mechanisms is involved in venous thromboembolism (VTE). Global plasma fibrin clot lysis markers, especially clot lysis time, have been reported to predict recurrent deep-vein thrombosis and pulmonary embolism. The current overview summarizes available data linking fibrinolysis to VTE and its long-term sequelae.

Publication History

Publication Date:
20 April 2021 (online)

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA