Macroscopic on-Site Evaluation (MOSE) of Acquired Specimens Of Solid Lesions During EUS-FNB: A Multicenter Study and a Comparison Between Needles Gauge

Aims The standard methods to obtain sampling during endoscopic ultrasonography (EUS) is the fine needle aspiration (FNA) which could be affected by the presence of cytopathologist in endoscopy room (ROSE). With the introduction of fine needle biopsy (FNB), the macroscopic on-site evaluation (MOSE) of the acquired specimen was proposed. Few studies are published about this issue and in all, except one, a 19G needle was used, influencing the accuracy. The primary aim of our study was to evaluate the yield and accuracy of MOSE with different needles’ gauge and the secondary aim was to identify factors influencing the yield of MOSE.

Methods Data from patients undergone EUS-FNB, for solid lesions, with MOSE evaluation of the specimen were collected in 6 endoscopic referral centers, for a total of 381 enrolled patients (146 F and 235 M). A multivariable analysis was run to identify variables independently related to MOSE diagnostic yield.

Results 381 samples were judged to be macroscopically adequate by the endosonographer. Needles size were 20G (41 %), 22G (46 %), and 25G (13 %). The median number of needle passes was 2 (IQR 2-3). The diagnostic yield of MOSE was of 89 % (CI 86-92 %). At multivariable logistic regression analysis, variables independently associated with MOSE diagnostic yield were larger needle diameter (20G vs. 25G, OR 11.52, CI 3.45-38.46; 22G vs. 25G, OR 6.01, CI 2.36-15.36) and ≥3 needle passes (OR 3.41, CI 1.39-8.35).

Conclusions MOSE showed high diagnostic yield and accuracy in a large sample. Its yield was further increased if performed with a large caliber FNB needle and more than two passes.

Citation Mangiavillano B, Frazzoni L, Togliani T et al. eP384 MACROSCOPIC ON-SITE EVALUATION (MOSE) OF ACQUIRED SPECIMENS OF SOLID LESIONS DURING EUS-FNB: A MULTICENTER STUDY AND A COMPARISON BETWEEN NEEDLES GAUGE. Endoscopy 2021; 53: S221.

Publication History

Article published online:
19 March 2021