Lymphocytic Colitis is the Most Common Cause of Non- Irritable Bowel Syndrome Chronic Diarrhea

Aims To diagnose the causes of non-irritable bowel syndrome chronic diarrhea in patients attending Specialized Medical Hospital, Mansoura University, Egypt.

Methods Sixty-one patients with non-irritable bowel syndrome chronic diarrhea were included. The following groups of patients were excluded: Known cases of IBD, hyperthyroidism, HIV, irritable bowel syndrome according to Rome IV criteria, chronic laxative abuse, colonic polyps, or colorectal cancer. All included patients were subjected to history taking, physical examination, laboratory investigations including Complete blood count (CBC), INR, ESR, CRP, HBs antigen, HIV antibody, HCV antibody, TSH, liver function tests, fecal calprotectin, stool analysis, culture & sensitivity, Anti-endomysial IgA, total IgA, serum Chromogranin A, and total IgE. Ileo-colonoscopy with ileal and colonic biopsies and histopathologic examination of the samples was done.

Results Twenty-seven cases (44.3 %) had microscopic colitis, lymphocytic type. The other cases of chronic diarrhea were diagnosed as ulcerative colitis (26.2 %), non-specific ileitis (16.4 %), eosinophilic colitis (9.8 %), tubulovillous adenoma (6.6 %), adenocarcinoma (6.6 %), and eosinophilic ileitis (4.9 %), in addition to Schistosomal colitis, infectious colitis, Crohn’s disease, Coeliac disease and non-specific colitis (1 case for each).

Conclusions Lymphocytic colitis is the most common cause of non-irritable bowel syndrome chronic diarrhea.

Citation: Abd El Razek M, Maher MM, Amin M etal. eP274 LYMPHOCYTIC COLITIS IS THE MOST COMMON CAUSE OF NON- IRRITABLE BOWEL SYNDROME CHRONIC DIARRHEA. Endoscopy 2021; 53: S188.

Publication History

Article published online:
19 March 2021