Endoscopy 2021; 53(S 01): S179-S180
DOI: 10.1055/s-0041-1724745
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Long-Term Incidence of Advanced Colorectal Neoplasia in Patients With Serrated Polyposis Syndrome

D Rodríguez-Alcalde
1   Hospital Universitario de Móstoles, Digestive Disease Section, Móstoles, Spain
,
G Castillo-López
1   Hospital Universitario de Móstoles, Digestive Disease Section, Móstoles, Spain
,
J López-Vicente
1   Hospital Universitario de Móstoles, Digestive Disease Section, Móstoles, Spain
,
L Hernández
1   Hospital Universitario de Móstoles, Digestive Disease Section, Móstoles, Spain
2   Hospital Santos Reyes, Digestive Disease Section, Aranda de Duero, Spain
,
M Lumbreras-Cabrera
1   Hospital Universitario de Móstoles, Digestive Disease Section, Móstoles, Spain
,
D Moreno-Sánchez
1   Hospital Universitario de Móstoles, Digestive Disease Section, Móstoles, Spain
› Author Affiliations
 

Aims Serrated polyposis syndrome (SPS) implies an increased risk of colorectal cancer (CRC), so intensive endoscopic surveillance has been recommended. Although a low incidence of CRC has been described under follow-up, few studies have evaluated long-term risk of developing advanced colorectal neoplasia in these patients.

Methods From March 2013 to October 2020, individuals who fulfilled WHO (2010) criteria I and/or III for SPS were retrospective and prospectively recruited. We selected those under endoscopic surveillance after resection of all lesions >3 mm in a high-quality colonoscopy. We excluded patients with total colectomy at SPS diagnosis and those with any interval between colonoscopies >3.5 years. We defined advanced neoplasia as advanced serrated lesion (≥10 mm and/or with dysplasia), advanced adenoma or CRC.

Results We recruited 129 patients, 11 (8.5 %) of whom presented CRC, all prevalent. One hundred and nine started endoscopic surveillance every 1-3 years, 53 (48.6 %) women, with a mean age at SPS diagnosis of 59.4 years (SD=8.9). Eighteen (16.5 %), 61 (56.0 %) and 30 (27.5 %) individuals fulfilled criterion I, III and both, respectively. We performed 342 colonoscopies (median = 3, IQR=2-4), with a median follow-up after colonic clearance of 5.0 years (IQR=3.3-7.2) and a median interval between them of 1.8 years (IQR=1.6-2.1). Five-year cumulative incidences of advanced serrated lesion and advanced adenoma were 17.2 % (95 %CI 9.4-25.0) and 6.8 % (95 %CI 1.5-12.1), respectively. Regarding advanced neoplasia, 5-year cumulative incidences were 21.6 % (95 %CI 13.1-30.1) globally, and 5.6 % (95 %CI 0-16.1), 10.8 % (95 %CI 2.7-19.0) and 50.8 % (95 %CI 30.6-71.1) in patients who fulfilled criterion I, III and both, respectively. No CRC was diagnosed and only 1 (0.9 %) patient underwent surgery, because of an unresectable polyp.

Conclusions During follow-up of our cohort of patients with SPS, no CRC was diagnosed and only one required surgery. Long-term cumulative incidence of advanced colorectal neoplasia was lower than expected according to previous studies.

Citation: Rodríguez-Alcalde D, Castillo-López G, López-Vicente J1 et al. eP249 LONG-TERM INCIDENCE OF ADVANCED COLORECTAL NEOPLASIA IN PATIENTS WITH SERRATED POLYPOSIS SYNDROME. Endoscopy 2021; 53: S179.



Publication History

Article published online:
19 March 2021

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