PDF herunterladen
CC BY-NC-ND 4.0 · J Lab Physicians 2021; 13(01): 070-073
DOI: 10.1055/s-0041-1724234
Case Report

Intrinsically Resistant Bacteria as Looming Disaster: A Rare Case Report of Elizabethkingia meningoseptica Meningitis in a Neonate

Priyadarshini Patro
1   Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Padma Das
1   Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Phalguni Padhi
2   Department of Neonatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
› Institutsangaben Funding None.
› Weitere Informationen
   Lizenzen und Reprints

Abstract

Elizabethkingia meningoseptica is a recognized cause of neonatal meningitis with high mortality rate of approximately 57%, but clinical data detailing these infections remain limited from India. Though this bacteria has a Gram-negative character, it is usually multidrug resistant to antibiotics usually prescribed for Gram-negative bacterial infections and susceptible to antibiotics for Gram-positive bacteria, thus poses a serious challenge to the treating clinicians. Such cases of neonatal meningitis is most commonly associated with prematurity with birth weight < 2,500 g, but here we report an uncommon case of neonatal meningitis due to this rare pathogen in a full-term neonate with weight as per gestational age. The isolate was multidrug resistant and discrepancy was seen between disc diffusion and automated antibiotic susceptibility testing for few antibiotics. The case was successfully managed by treatment with combination of piperacillin-tazobactam, vancomycin, chloramphenicol, and rifampicin for a total duration of 28 days, due to prompt identification of the causative organism and initiation of appropriate antimicrobial therapy early. E. meningoseptica can cause severe infection, with risk of high mortality and neurological sequelae in neonates. Intensive care and multidisciplinary interventions are crucial for case management.

Keywords

Elizabethkingia meningoseptica - neonatal meningitis - multidrug resistant - multidisciplinary interventions


Publikationsverlauf

Artikel online veröffentlicht:
22. Februar 2021

© 2021. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Bhat KS, Priya R, Krishnan L, Kanungo R. Elizabethkingia meningoseptica bacteremia in a neonate: a case report and mini-review of the literature. J Curr Res Sci Med 2016; 2: 42-45
    CrossrefGoogle Scholar
  • 2 Tak V, Mathur P, Varghese P, Misra MC. Elizabethkingia meningoseptica: an emerging pathogen causing meningitis in a hospitalized adult trauma patient. Indian J Med Microbiol 2013; 31 (03) 293-295
    CrossrefPubMedGoogle Scholar
  • 3 Ghafur A, Vidyalakshmi PR, Priyadarshini K, Easow JM, Raj R, Raja T. Elizabethkingia meningoseptica bacteremia in immunocompromised hosts: the first case series from India. South Asian J Cancer 2013; 2 (04) 211-215
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 4 Chamalla SK, Karri SS, Koripadu S, Mohan N. Elizabethkingia meningoseptica: an emerging pathogen causing neonatal meningitis. J Dr NTR Univ Health Sci 2018; 7 (03) 213
    CrossrefGoogle Scholar
  • 5 Hoque SN, Graham J, Kaufmann ME, Tabaqchali S. Chryseobacterium (Flavobacterium) meningosepticum outbreak associated with colonization of water taps in a neonatal intensive care unit. J Hosp Infect 2001; 47 (03) 188-192
    CrossrefPubMedGoogle Scholar
  • 6 Issack MI, Neetoo Y. An outbreak of Elizabethkingia meningoseptica neonatal meningitis in Mauritius. J Infect Dev Ctries 2011; 5 (12) 834-839
    CrossrefPubMedGoogle Scholar
  • 7 Arbune M, Fotea S, Nechita A, Stefanescu V. Emerging infection with Elizabethkingia meningoseptica in neonate. A case report. J Crit Care Med (Targu Mures) 2018; 4 (03) 96-100
    CrossrefPubMedGoogle Scholar