Tom Edgington, a formative personality in the Thrombosis and Haemostasis research community, has passed away in January 2021. While we would respect his wish to not have an obituary, we would still like to pay tribute to his accomplishments, most notably his contributions to elucidating the biology of tissue factor, e.g., cloning its cDNA in 1987. What would be better suited than to let him speak in his own words by referencing his article “Surfing tissue factor” published in Thrombosis & Haemostasis in 2007 to summarize the decade-long history of tissue factor research. This article featured the above original illustration of the typical high-affinity interaction between tissue factor (shown as a Southern Californian surfboard) and factor VIIa (pictured as Tom Edgington) in a configuration that allowed elegantly surfing the unpredictable waves of the Pacific Ocean.
19 February 2021 (online)
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- 1 Edgington TS. Surfing tissue factor. From the predicted to the discovery and elucidation of unanticipated functions and biology of potential significance. Thromb Haemost 2007; 98 (01) 36-37