J Pediatr Infect Dis 2021; 16(03): 129-133
DOI: 10.1055/s-0041-1724024
Original Article

Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Serkan Tursun
1  Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Ayşegül Alpcan
1  Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Metin Özsoy
2  Department of Infectious Disease and Clinical Microbiology, Ankara Training and Research, Hospital Ankara, Turkey
,
Nermin Dindar Badem
3  Department of Medical Biochemistry, Gülhane Training and Research Hospital, Ankara, Turkey
,
Yaşar Kandur
1  Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Banu Çelikel Acar
4  Department of Pediatric Nephrology, School of Medicine, Ankara City Hospital, University of Health Sciences, Ankara, Turkey
› Author Affiliations
Funding None.

Abstract

Objective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI).

Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test.

Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.6 ± 3.2 (range = 1–14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 ± 323 vs. 490 ± 299 pg/mL, p = 0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve = 0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI.

Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.

Authors' Contributions

S.T., A.A., M.O., N.D.B., and B.C.A. contributed in the completion of this document and attest to its validity on behalf of the co-authors.




Publication History

Received: 01 August 2020

Accepted: 13 January 2021

Publication Date:
25 February 2021 (online)

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