J Pediatr Infect Dis 2021; 16(03): 111-115
DOI: 10.1055/s-0041-1724020
Original Article

Cerebrospinal Fluid and Serum C-Reactive Protein among Children with Acute Encephalitis Syndrome

1  Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India
,
Dinesh Kumar
1  Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India
,
Alok Tiwari
2  Department of Child Health, National Health Mission, Uttar Pradesh, India
,
Nishant Sharma
1  Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India
,
Rajesh Kumar Yadav
1  Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India
,
Krishan Mohan Shukla
1  Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India
› Author Affiliations
Funding None.

Abstract

Objectives This study aimed to evaluate the positivity of C-reactive protein (CRP) in cerebrospinal fluid (CSF) and serum in children presented with clinical diagnosis of acute encephalitis syndrome (AES).

Methods A total of 164 children between 6 months and 14 years with clinical diagnosis of AES were investigated. Qualitative CRP (slide agglutination) was determined in CSF and serum sample of each patient. On the basis of clinical examination and investigations, all the patients were divided into four groups as pyogenic meningitis, viral encephalitis, tuberculous meningitis, and cerebral malaria. The positivity of CRP in CSF and serum were compared in these groups.

Results CSF CRP was found to be positive in the majority of patients with pyogenic meningitis and a statistically significant (p ≤ 0.001) association was found between CSF CRP and final diagnosis of AES, while this association was nonsignificant (p = 0.141) in case of serum CRP. When we compared the CSF and serum CRP, serum CRP was found to be more suggestive of tuberculous meningitis, viral encephalitis, and cerebral malaria while CSF CRP was more sensitive and specific for the diagnosis of pyogenic meningitis.

Conclusion The sensitivity and specificity of CSF CRP for pyogenic meningitis was quite high. Serum CRP with a high sensitivity can be used as a screening test for different types of meningitis and cerebral malaria; however, its diagnostic accuracy has yet to be established.



Publication History

Received: 30 August 2020

Accepted: 24 December 2020

Publication Date:
25 February 2021 (online)

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