To Radiate Upfront or at Initial Recurrence after Gross Total Resection of Newly Diagnosed WHO II Meningiomas? A Propensity Score–Adjusted Analysis

Background: Clinical equipoise still exists in the management of WHO grade II meningiomas following gross total resection (GTR). Specifically, whether to radiate upfront after resection or at initial recurrence. This study aims to compare strategy failure-free survival (SFFS) between two treatment strategies after GTR: adjuvant radiation versus observation with salvage radiation after initial recurrence.

Methods: A retrospective review of patients who underwent GTR of newly diagnosed WHO grade II meningiomas at our institution between 1996 and 2019 was performed. Treatment failure was defined as failure of first radiation. To assess the association between treatment strategy and SFFS while accounting for potential confounders, a multivariable Cox regression analysis adjusted for the propensity score (PS) and inverse probability of treatment weighted (IPTW) Cox regression analysis were performed.

Results: There were 161 patients who underwent GTR as initial treatment and were included in this study. Of these, 39 patients received adjuvant fractionated external beam radiation therapy (fEBRT) and 121 patients were observed. Failure of adjuvant radiation occurred in 8 (20.5%) patients. Out of 37 (30.6%) patients who were observed and developed recurrence, 32 (26.4%) were treated with salvage radiation (IMRT or SRS) and 5 (4.1%) were treated with salvage surgery. There were 8 (25.0%) patients who experienced failure of salvage radiation.

The 3- and 5-year SFFS was 86.1 and 59.2% for the adjuvant radiation strategy versus 97.7 and 90.3% for the observation with salvage radiation treatment strategy, respectively. The observation with salvage radiation treatment strategy achieved a significantly longer SFFS than the adjuvant radiation cohort (p = 0.0005). PS and IPTW Cox regression models demonstrated that the observation with salvage radiation treatment strategy was significantly associated with prolonged SFFS (HR = 0.21; 95% CI: 0.07–0.70 and HR = 0.21; 95% CI: 0.07–0.58, respectively).

Conclusion: SFFS was significantly greater in patients treated with observation followed by salvage radiation as compared with adjuvant radiation after GTR of newly diagnosed WHO grade II meningiomas. A treatment strategy of observation with salvage radiation for initial recurrence may be advantageous over adjuvant radiation by reserving radiation for recurrence.

Fig. 1 Flow diagram of patients utilizing different strategies after GTR of a newly diagnosed WHO grade II meningioma. The start of the arrow indicates index time and the end of the arrow denotes event time for progression-free survival. *Salvage surgery excluded from final analysis. GTR, gross total resection; IMRT, intensity modulated radiotherapy; SRS, stereotactic radiosurgery.

Fig. 2 Progression-free survival in patients undergoing GTR, stratified by adjuvant radiation versus (A) observation with salvage radiation, (B) observation only, (C) salvage radiation only.

Publication History

Article published online:
12 February 2021