Dtsch Med Wochenschr 2015; 140(21): 1587-1592
DOI: 10.1055/s-0041-107338
Dossier
Schlaganfall / vaskuläre Demenz
© Georg Thieme Verlag KG Stuttgart · New York

Blutdruckbehandlung im Akutstadium des Schlaganfalls

Blood pressure treatment in the acute stage of stroke
Michael Johann Koziolek
1   Klinik f. Nephrologie & Rheumatologie, Universitätsmedizin Göttingen
,
Stephan Lüders
2   Med. Klinik-Nephrologie/Geriatrie, St.-Josefs-Hospital Cloppenburg
› Author Affiliations
Further Information

Publication History

Publication Date:
21 October 2015 (online)

Zusammenfassung

Die Ergebnisse bisheriger Studien zur Blutdrucktherapie bei akutem Schlaganfall erlauben wenige allgemeingültige Therapieempfehlungen. Es sollte versucht werden, ein konstantes Blutdruckniveau ohne große Schwankungen zu erreichen. Eine antihypertensive Therapie im Akutstadium des Schlaganfalls sollte nur bei stark erhöhten Werten eingeleitet werden. Hohe Blutdruckwerte werden bei Patienten mit ischämischem Schlaganfall toleriert, sofern keine Thrombolyse in Betracht kommt. Sollte diese angestrebt werden, muss der Blutdruck schnell auf einen Zielbereich von zumindest < 180 mmHg abgesenkt werden. Im Falle intrazerebraler Blutung scheint eine Blutdruckabsenkung von Vorteil zu sein. Die ESO empfiehlt eine Absenkung auf < 140 mmHg systolisch innerhalb einer Stunde, nach Empfehlungen der ESH und der EUSI jedoch nicht mehr als 20 %.

Abstract

The results of previous studies on blood pressure in acute stroke therapy allow a few generally valid therapeutic recommendations. Efforts should be made to achieve a constant blood pressure level without major fluctuations. An antihypertensive therapy in the acute stage of stroke should be initiated only at highly elevated values. High blood pressure levels can be tolerated in patients with ischemic stroke unless thrombolytic comes into consideration. Should this be desired, the blood pressure must be quickly lowered to a target range of at least < 180 mmHg. In the case of intracerebral hemorrhage a blood pressure reduction appears to be beneficial. The ESO recommends a reduction to < 140 mmHg systolic within one hour, according to recommendations of the ESH and the EUSI but not more than 20 %.

 
  • Literatur

  • 1 Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH / ESC Practice Guidelines for the Management of Arterial Hypertension. Blood Press 2014; 23: 3-16
  • 2 Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999; 22: 391-397
  • 3 Qureshi AI, Ezzeddine MA, Nasar A et al. Prevalence of elevated blood pressure in 563, 704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med 2007; 25: 32-38
  • 4 Leira R, Millán M, Díez-Tejedor E et al. Age determines the effects of blood pressure lowering during the acute phase of ischemic stroke: the TICA study. Hypertension 2009; 54: 769-774
  • 5 Patarroyo SX, Anderson C. Blood pressure lowering in acute phase of stroke: latest evidence and clinical implications. Ther Adv Chronic Dis 2012; 3: 163-171
  • 6 Ishitsuka K, Kamouchi M, Hata J et al. High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry. Hypertension 2014; 63: 54-60
  • 7 Ntaios G, Lambrou D, Michel P. Blood pressure changes in acute ischemic stroke and outcome with respect to stroke etiology. Neurology 2012; 79: 1440-1448
  • 8 Lüders S, Dechend R, Eckert S et al. 24-h-Langzeitblutdruckmessung (ABDM). Der Kardiologe 2013; 7: 194-208
  • 9 Sargento-Freitas J, Laranjinha I, Galego O et al. Nocturnal blood pressure dipping in acute ischemic stroke. Acta Neurol Scand 2015; DOI: 10.1111/ane.12402.
  • 10 Kario K, Pickering TG, Matsuo T et al. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension 2001; 38: 852-857
  • 11 Chung CP, Yong CS, Chang FC et al. Stroke etiology is associated with outcome in posterior circulation stroke. Ann Clin Transl Neurol 2015; 2: 510-517
  • 12 Toyoda K, Okada Y, Fujimoto S et al. Blood pressure changes during the initial week after different subtypes of ischemic stroke. Stroke 2006; 37: 2637-2639
  • 13 Steiner T, Al-Shahi Salman R, Beer R et al. European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage. Int J Stroke 2014; 9: 840-855
  • 14 Wang X, Arima H, Heeley E et al. Magnitude of blood pressure reduction and clinical outcomes in acute intracerebral hemorrhage: intensive blood pressure reduction in acute cerebral hemorrhage trial study. Hypertension 2015; 65: 1026-1032
  • 15 Sakamoto Y, Koga M, Todo K et al. Relative systolic blood pressure reduction and clinical outcomes in hyperacute intracerebral hemorrhage: the SAMURAI-ICH observational study. J Hypertens 2015; 33: 1069-1073
  • 16 O‘Collins VE, Donnan GA, Macleod MR, Howells DW. Hypertension and experimental stroke therapies. J Cereb Blood Flow Metab 2013; 33: 1141-1147
  • 17 Sandset EC, Murray G, Boysen G et al. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial. Lancet 2011; 377: 741-750
  • 18 Ankolekar S, Fuller M, Cross I et al. Feasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the rapid intervention with glyceryl trinitrate in Hypertensive Stroke Trial (RIGHT, ISRCTN66434824). Stroke 2013; 44: 3120-3128
  • 19 Robinson TG, Potter JF, Ford GA et al. Effects of antihypertensive treatment after acute stroke in the Continue or Stop Post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomised, open, blinded-endpoint trial. Lancet Neurol 2010; 9: 767-775
  • 20 Ahmed N, Wahlgren N, Brainin M et al. Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR). Stroke 2009; 40: 2442-2449
  • 21 Doutheil A, Schrader J, Holzgraefe M et al. Häufigkeit und Bedeutung einer nächtlichen Hypertonie bei Patienten nach cerebralen Insulten. Nieren Hochdruckkr 1992; 21: 492-494
  • 22 Adams HP, Bendixen BH, Kappelle LJ et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10 172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41
  • 23 Gorelick PB, Caplan LR, Hier DB et al. Racial differences in the distribution of anterior circulation occlusive disease. Neurology 1984; 34: 54-59
  • 24 Sacco RL, Kargman DE, Gu Q, Zamanillo MC. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke 1995; 26: 14-20
  • 25 Anderson CS, Heeley E, Huang Y et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med 2013; 368: 2355-2365
  • 26 Manning L, Hirakawa Y, Arima H et al. Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial. Lancet Neurol 2014; 13: 364-373
  • 27 Bath P, Chalmers J, Powers W et al. International Society of Hypertension (ISH): statement on the management of blood pressure in acute stroke. J Hypertens 2003; 21: 665-672
  • 28 Steiner T, Kaste M, Forsting M et al. Recommendations for the management of intracranial haemorrhage – part I: spontaneous intracerebral haemorrhage. The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee. Cerebrovasc Dis 2006; 22: 294-316
  • 29 Qureshi AI, Palesch YY. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II: design, methods, and rationale. Neurocrit Care 2011; 15: 559-576
  • 30 Groth W, Blume A, Gohlke P et al. Chronic pretreatment with candesartan improves recovery from focal cerebral ischaemia in rats. J Hypertens 2003; 21: 2175-2182
  • 31 Schrader J, Lüders S, Kulschewski A et al. The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors. Stroke 2003; 34: 1699-1703
  • 32 Dyker AG, Grosset DG, Lees K. Perindopril reduces blood pressure but not cerebral blood flow in patients with recent cerebral ischemic stroke. Stroke 1997; 28: 580-583
  • 33 Lisk DR, Grotta JC, Lamki LM et al. Should hypertension be treated after acute stroke? A randomized controlled trial using single photon emission computed tomography. Arch Neurol 1993; 50: 855-862
  • 34 Wahlgren NG, MacMahon DG, De Keyser J et al. Intravenous Nimodipine West European Stroke Trial (INWEST) of nimodipine in the treatment of acute ischaemic stroke. Cerebrovasc Dis 1994; 4: 204-210
  • 35 Wang H, Tang Y, Rong X et al. Effects of early blood pressure lowering on early and long-term outcomes after acute stroke: an updated meta-analysis. PLoS One 2014; 9: e97917
  • 36 He J, Zhang Y, Xu T et al. Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial. JAMA 2014; 311: 479-489
  • 37 ENOS Trial Investigators. Bath PM, Woodhouse L, Scutt P et al. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet Neurol 2015; 385: 617-628
  • 38 Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol 2009; 8: 1006-1018
  • 39 Rothwell PM, Giles MF, Chandratheva A et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 2007; 370: 1432-1442
  • 40 Rothwell PM, Howard SC, Dolan E et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895-905
  • 41 Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin DEGAM-Leitlinie Nr. 8. omikron publishing Düsseldorf: 2012