Update: Immunsuppression bei Organtransplantationen

Kernaussagen

Während noch immer Konzepte für eine auf den einzelnen Patienten maßgeschneiderte Immunsuppression gesucht werden, gibt es mittlerweile gute Strategien zur Einsparung von CNIs, die mit einer Reduktion der CNI-assoziierten Nebenwirkungen einhergehen. Insbesondere durch eine Induktionstherapie bei der Nierentransplantation können frühe Abstoßungsperioden reduziert, CNIs verzögert appliziert und Steroide frühzeitig ausgeschlichen werden. Die steroidfreie Immunsuppression nach Nierentransplantationen hat allerdings in den nationalen Leitlinien aufgrund des unklaren Nutzen-Risikoprofiles bisher keinen Einzug gehalten.

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