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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2021; 11(02): 107-109
DOI: 10.1055/s-0040-1722802
Case Report

Late-Onset Narcolepsy: A Case Report with Brief Review of the Literature

Jeny Jacob
1   Department of General Medicine, K.S. Hegde Medical Academy, Mangalore, Karnataka, India
,
Rajesh Venkataram
2   Department of Pulmonary Medicine, K.S. Hegde Medical Academy, Mangalore, Karnataka, India
,
Nandakishore Baikunje
2   Department of Pulmonary Medicine, K.S. Hegde Medical Academy, Mangalore, Karnataka, India
,
Rashmi Soori
3   Department of Anaesthesiology, K.S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
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Abstract

Narcolepsy, a sleep disorder, has its onset in childhood and early adulthood but rarely in older adults. This case report focuses on a man in his late fifties who was noticed to have excessive daytime sleepiness during his stay in our hospital for an unrelated medical ailment. He was further evaluated with overnight polysomnography and next day multiple sleep latency test which confirmed the diagnosis of narcolepsy.

Keywords

narcolepsy - excessive daytime sleepiness - Multiple Sleep Latency Test


Publication History

Article published online:
13 February 2021

© 2021. Nitte (Deemed to be University). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Suzuki S, Uehara T, Ohira Y, Ikusaka M. Narcolepsy with cataplexy in an elderly woman. J Gen Intern Med 2015; 30 (08) 1222-1224
    CrossrefPubMedSearch in Google Scholar
  • 2 Reynolds CF III. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC; 2013:372–378
  • 3 Berry RB. Fundamentals of sleep medicine. Elsevier Saunders; 2012:451–470
  • 4 de Lecea L, Kilduff TS, Peyron C. et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998; 95 (01) 322-327
    CrossrefPubMedSearch in Google Scholar
  • 5 Thannickal TC, Moore RY, Nienhuis R. et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27 (03) 469-474
    CrossrefPubMedSearch in Google Scholar
  • 6 Thannickal TC, Nienhuis R, Siegel JM. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep 2009; 32 (08) 993-998
    CrossrefPubMedSearch in Google Scholar
  • 7 Mignot E, Lin X, Hesla PE, Dement WC, Guilleminault C, Grumet FC. A novel HLA DR17,DQ1 (DQA1-0102/DQB1-0602 positive) haplotype predisposing to narcolepsy in Caucasians. Sleep 1993; 16 (08) 764-765
    CrossrefPubMedSearch in Google Scholar