CC BY 4.0 · Glob Med Genet 2020; 07(04): 095-100
DOI: 10.1055/s-0040-1722303
Review Article

Genetics of Dentofacial and Orthodontic Abnormalities

Praveen Kumar Neela
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Anjana Atteeri
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Pavan Kumar Mamillapalli
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Vasu Murthy Sesham
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Sreekanth Keesara
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Jaya Chandra
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Udayini Monica
1  Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India
,
Vasavi Mohan
2  Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India
› Author Affiliations

Abstract

The development of craniofacial complex and dental structures is a complex and delicate process guided by specific genetic mechanisms. Genetic and environmental factors can influence the execution of these mechanisms and result in abnormalities. An insight into the mechanisms and genes involved in the development of orofacial and dental structures has gradually gained by pedigree analysis of families and twin studies as well as experimental studies on vertebrate models. The development of novel treatment techniques depends on in-depth knowledge of the various molecular or cellular processes and genes involved in the development of the orofacial complex. This review article focuses on the role of genes in the development of nonsyndromic orofacial, dentofacial variations, malocclusions, excluding cleft lip palate, and the advancements in the field of molecular genetics and its application to obtain better treatment outcomes.



Publication History

Publication Date:
01 February 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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