Open Access
CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2022; 26(01): e158-e166
DOI: 10.1055/s-0040-1722250
Systematic Review

The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Natalia Ferrazoli 
1   Postgraduate Program in Health, Interdisciplinary Practice and Rehabilitation, Universidade Estadual de Campinas, Campinas, SP, Brazil
2   Clinica Ouvire, Campinas, SP, Brazil
,
Caroline Donadon 
2   Clinica Ouvire, Campinas, SP, Brazil
3   Postgraduate Program in Child and Adolescent Health, Universidade Estadual de Campinas, Campinas, SP, Brazil
,
Adriano Rezende 
2   Clinica Ouvire, Campinas, SP, Brazil
,
Piotr H. Skarzynski 
4   Department of Teleaudiology and Hearing Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, Warsaw/Kajetany, Poland
5   Department of Heart Failure and Cardiac Rehabilitation, Institute of Sensory Organs, Warsaw, Poland
,
Milaine Dominici Sanfins 
2   Clinica Ouvire, Campinas, SP, Brazil
6   Centro de Eletrofisiologia e Neuroaudiologia Avançada, Sao Paulo, SP, Brazil
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Abstract

Introduction Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination.

Objective To review the literature on the application and findings of P300 as an indicator of PD.

Data Analysis The samples ranged from 7 to 166 individuals. Young adult and elderly male patients composed most study samples. The Mini-Mental State Examination test, the Unified Parkinson Disease Rating Scale, and the Hoehn and Yahr Scale were used to assess neurological and cognitive function. In terms of testing hearing function, few studies have focused on parameters other than the P300. The factors we focused on were how the P300 was modified by cognitive effects, its correlation with different PD scales, the effect of performing dual tasks, the effect of fatigue, and the influence of drug treatments.

Conclusion The use of the P300 appears to be an effective assessment tool in patients with PD. This event-related potential seems to correlate well with other neurocognitive tests that measure key features of the disease.

Keywords

Parkinson disease - attention - P300 - event-related potential - elderly


Publication History

Received: 12 September 2020

Accepted: 08 November 2020

Article published online:
29 March 2021

© 2021. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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