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CC BY 4.0 · TH Open 2021; 05(01): e14-e23
DOI: 10.1055/s-0040-1721782
Original Article

Effects of a 1-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors: A Randomized Controlled Trial

Siv Kjølsrud Bøhn
1   Faculty of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway
,
Inger Thune
2   Department of Oncology, Oslo University Hospital, Oslo, Norway
3   Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
,
Vidar Gordon Flote
2   Department of Oncology, Oslo University Hospital, Oslo, Norway
,
Hanne Frydenberg
2   Department of Oncology, Oslo University Hospital, Oslo, Norway
,
Gro Falkenér Bertheussen
4   Department of Physical Medicine and Rehabilitation, St. Olav University Hospital, Trondheim, Norway
5   Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway
,
Anders Husøy
6   Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
,
Frøydis Fjeldheim
2   Department of Oncology, Oslo University Hospital, Oslo, Norway
,
Sonja Hjellegjerde Brunvoll
7   Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
,
Anette Hjartåker
7   Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
,
Marie-Christine Mowinckel
8   Department of Haematology, Oslo University Hospital and University of Oslo, Oslo, Norway
,
Per Morten Sandset
8   Department of Haematology, Oslo University Hospital and University of Oslo, Oslo, Norway
,
Per Ole Iversen
7   Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
8   Department of Haematology, Oslo University Hospital and University of Oslo, Oslo, Norway
› Author Affiliations Funding The study was supported by grants from the Norwegian Research Council (#181809/v50), the Foundation for the Norwegian Health and Rehabilitation Organizations (#59010), Health Trust Region South East (#2811507), and Mills Ltd.
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Abstract

Introduction Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients.

Methods Fifty-five women (35–75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n = 29) lasting 1 year or to a control group (n = 26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1 + 2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months.

Results Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake.

Conclusion Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

Keywords

Breast Neoplasms - hemostasis - physical activity - postmenopause - von Willebrand factor

Supplementary Material



Publication History

Received: 04 June 2020

Accepted: 10 November 2020

Article published online:
06 February 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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