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J Pediatr Infect Dis 2021; 16(01): 031-035
DOI: 10.1055/s-0040-1721446
Original Article

Risk Factors for Extensively Drug-Resistant Acinetobacter baumannii in Neonatal Patients

Recep Tekin 
1   Department of Infectious Disease and Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkey
,
İlyas Yolbaş 
2   Department of Neonatology, Dicle University School of Medicine, Diyarbakir, Turkey
,
Fatma Bozkurt
3   Department of Infectious Disease, Diyarbakır Gazi Yaşargil Education and Research Hospital, Sağlık Bilimleri University, Diyarbakir, Turkey
,
Saliha Çevik
4   Department of Infectious Disease, Diyarbakır Children's Hospital, Diyarbakir, Turkey
,
Handan Alay 
5   Department of Infectious Disease and Clinical Microbiology, Atatürk University School of Medicine, Erzurum, Turkey
,
Nida Özcan 
6   Department of Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkey
,
Fesih Aktar
7   Department of Pediatric, Dicle University School of Medicine, Diyarbakir, Turkey
,
Habibe Çolak
4   Department of Infectious Disease, Diyarbakır Children's Hospital, Diyarbakir, Turkey
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Abstract

Introduction Extensively drug-resistant Acinetobacter baumannii infections (XDRABIs) are significant causes of mortality and morbidity in neonatal patients due to the treatment difficulties and limitations. In the present study, we aimed to evaluate the characteristics and risk factors for XDRABIs acquisition during hospitalization.

Methods We investigated the risk factors of health care-associated infections (HC-AIs) caused by multidrug-resistant A. baumannii in the four neonatal units between January 2008 and December 2018. The patients and the control group's data and culture results were recorded and analyzed on a daily basis.

Results A total of 70 patients infected with XDRABIs and 118 control patients were included in the study. Univariate analysis showed that prematurity, gestation age, birth weight, mechanical ventilation, parenteral nutrition, transfusion, use of glycopeptides, and aminoglycosides were significantly associated with XDRABIs. In the univariate analysis, gestation age, mechanical ventilation, transfusion, parenteral nutrition, use of glycopeptides, carbapenems, and aminoglycosides were significantly associated with mortality. In the multiple logistic regression analysis, gestation age (p = 0.034), transfusion (p < 0.001), and use of glycopeptides (p = 0.019) were determined to be independent predictors of mortality in newborn infants with XDRABIs (R-square = 0.546).

Conclusion Determination of the risk factors, avoiding invasive procedures, rational use of antibiotics will lead to a decrease in the mortality and morbidity rates related to XDRABIs.

Keywords

Acinetobacter baumannii - neonatal - risk factor

Note

This work has been presented as a poster in the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID); April 22 to 25, 2017, Vienna, Austria.




Publication History

Received: 12 June 2020

Accepted: 20 October 2020

Article published online:
16 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
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