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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2021; 56(04): 432-437
DOI: 10.1055/s-0040-1721364
Artigo Original
Artroscopia e Traumatologia do Esporte

Estresse oxidativo e características ultrassonográficas do tendão anormal em jogadores de futebol de elite (um estudo piloto)

Article in several languages: português | English
Michele Abate 
1   Medical Facilities Delfino Pescara, Pescara, Itália
,
Luigi Di Carlo
1   Medical Facilities Delfino Pescara, Pescara, Itália
,
Giulio Cocco
2   Centro Analisi Biochimiche dello Sport, Via Renzetti, Lanciano (CH), Itália
,
Antonino Cocco
2   Centro Analisi Biochimiche dello Sport, Via Renzetti, Lanciano (CH), Itália
,
Ernesto Sabatini
1   Medical Facilities Delfino Pescara, Pescara, Itália
,
Vincenzo Salini
2   Centro Analisi Biochimiche dello Sport, Via Renzetti, Lanciano (CH), Itália
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Resumo

Objetivo Dados experimentais ultrassonográficos sugerem que o estresse oxidativo desempenha um papel importante na patogênese das tendinopatias. No entanto, essa hipótese permanece especulativa em humanos, dado que faltam dados clínicos para comprová-la. Recentemente, uma nova metodologia permitiu quantificar o estresse oxidativo in vivo medindo a concentração de hidroperóxidos de compostos orgânicos, que tem sido utilizada como um marcador relacionado ao estresse oxidativo em várias condições patológicas e fisiológicas. Dada a confiabilidade desse teste e a falta de informação em sujeitos com tendinopatias, o objetivo do presente estudo foi avaliar o status de estresse oxidativo em jogadores profissionais de elite com e sem características ultrassonográficas de dano tendinoso.

Métodos Em 73 jogadores de elite foram avaliados parâmetros metabólicos e o estresse oxidativo foi medido por meio de um teste específico (expresso como unidades U-Carr). Por isso, foi realizada uma avaliação ultrassonográfica dos tendões de Aquiles e patelar.

Resultados Não foram observadas relações significativas entre parâmetros metabólicos e biomarcadores de estresse oxidativo. Os tendões de Aquiles e patelar mostraram um padrão ecográfico normal em 58 atletas, e anormalidades ultrassonográficas em 15. Os atletas com alterações, em comparação com aqueles com quadro normal, apresentaram níveis significativamente mais elevados de U-Carr (p = 0,000), índice de massa corporal (IMC) (p = 0,03) e eram mais velhos (p = 0,005). A diferença nos valores de U-Carr entre os sujeitos permaneceu significativa também após ajuste por idade e IMC.

Conclusão Os resultados deste estudo corroboram a hipótese de que as substâncias oxidativas, também aumentadas a nível sistêmico e não apenas a nível local, podem favorecer danos no tendão.

Nível de Evidência IV (estudo piloto).

Palavras-chave

tendão de Aquiles - futebol - estresse oxidativo - tendão patelar - ultrassonografia

Nota

O presente trabalho foi desenvolvido no Delfino Training Center (Città Sant'Angelo [Pescara]) e Centro Analisi Biochimiche dello Sport, (Lanciano [Chieti]), Itália.


Suporte Financeiro

Não houve suporte financeiro de fontes públicas, comerciais, ou sem fins lucrativos.




Publication History

Received: 18 April 2020

Accepted: 17 September 2020

Article published online:
10 February 2021

© 2021. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • Referências

  • 1 Bestwick CS, Maffulli N. Reactive oxygen species and tendinopathy: do they matter?. Br J Sports Med 2004; 38 (06) 672-674
    CrossrefPubMedGoogle Scholar
  • 2 Abate M, Silbernagel KG, Siljeholm C. et al. Pathogenesis of tendinopathies: inflammation or degeneration?. Arthritis Res Ther 2009; 11 (03) 235
    CrossrefPubMedGoogle Scholar
  • 3 Kilk K, Meitern R, Härmson O, Soomets U, Hõrak P. Assessment of oxidative stress in serum by d-ROMs test. Free Radic Res 2014; 48 (08) 883-889
    CrossrefPubMedGoogle Scholar
  • 4 Hitsumoto T. Efficacy of the Reactive Oxygen Metabolite Test as a Predictor of Initial Heart Failure Hospitalization in Elderly Patients With Chronic Heart Failure. Cardiol Res 2018; 9 (03) 153-160
    CrossrefPubMedGoogle Scholar
  • 5 Hirata Y, Yamamoto E, Tokitsu T. et al. The Pivotal Role of a Novel Biomarker of Reactive Oxygen Species in Chronic Kidney Disease. Medicine (Baltimore) 2015; 94 (25) e1040
    CrossrefPubMedGoogle Scholar
  • 6 Nakajima A, Aoki Y, Shibata Y. et al. Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis. Mod Rheumatol 2014; 24 (06) 926-930
    CrossrefPubMedGoogle Scholar
  • 7 Kotani K, Sakane N, Kamimoto M, Taniguchi N. Levels of reactive oxygen metabolites in patients with knee osteoarthritis. Australas J Ageing 2011; 30 (04) 231-233
    CrossrefPubMedGoogle Scholar
  • 8 Matsuzawa Y, Kawashima T, Kuwabara R. et al. Change in serum marker of oxidative stress in the progression of idiopathic pulmonary fibrosis. Pulm Pharmacol Ther 2015; 32: 1-6
    CrossrefPubMedGoogle Scholar
  • 9 D'Arena G, Seneca E, Migliaccio I. et al. Oxidative stress in chronic lymphocytic leukemia: still a matter of debate. Leuk Lymphoma 2019; 60 (04) 867-875
    CrossrefPubMedGoogle Scholar
  • 10 Cornelli U, Belcaro G, Cesarone MR, Finco A. Analysis of oxidative stress during the menstrual cycle. Reprod Biol Endocrinol 2013; 11: 74
    CrossrefPubMedGoogle Scholar
  • 11 Suzuki K, Yanagi K, Shimizu M. et al. Effect of growth hormone replacement therapy on plasma diacron-reactive oxygen metabolites and endothelial function in Japanese patients: The GREAT clinical study. Endocr J 2018; 65 (01) 101-111
    CrossrefPubMedGoogle Scholar
  • 12 Kotani K, Tsuzaki K, Taniguchi N, Sakane N. Correlation between reactive oxygen metabolites & atherosclerotic risk factors in patients with type 2 diabetes mellitus. Indian J Med Res 2013; 137 (04) 742-748
    PubMedGoogle Scholar
  • 13 Kotani K, Tsuzaki K, Sakane N, Taniguchi N. The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects. J Clin Med Res 2012; 4 (03) 161-166
    PubMedGoogle Scholar
  • 14 Chida R, Hisauchi I, Toyoda S. et al. Impact of irbesartan, an angiotensin receptor blocker, on uric acid level and oxidative stress in high-risk hypertension patients. Hypertens Res 2015; 38 (11) 765-769
    CrossrefPubMedGoogle Scholar
  • 15 Kotani K, Yamada T. Oxidative stress and metabolic syndrome in a Japanese female population. Australas J Ageing 2012; 31 (02) 124-127
    CrossrefPubMedGoogle Scholar
  • 16 Bianchi VE, Ribisl PM. Reactive Oxygen Species Response to Exercise Training and Weight Loss in Sedentary Overweight and Obese Female Adults. J Cardiopulm Rehabil Prev 2015; 35 (04) 263-267
    CrossrefPubMedGoogle Scholar
  • 17 Schöttker B, Brenner H, Jansen EH. et al. Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data. BMC Med 2015; 13: 300
    CrossrefPubMedGoogle Scholar
  • 18 Cornelli U, Belcaro G, Ledda A, Feragalli B. Oxidative stress following administration of levothyroxine in subjects suffering from primary hypothyroidism. Panminerva Med 2011; 53 (03, Suppl 1): 95-98
    PubMedGoogle Scholar
  • 19 Chen JT, Kotani K. Serum γ-glutamyltranspeptidase and oxidative stress in subjectively healthy women: an association with menopausal stages. Aging Clin Exp Res 2016; 28 (04) 619-624
    CrossrefPubMedGoogle Scholar
  • 20 Kıraç FS. Is Ethics Approval Necessary for all Trials? A Clear But Not Certain Process. Mol Imaging Radionucl Ther 2013; 22 (03) 73-75
    CrossrefPubMedGoogle Scholar
  • 21 Sunding K, Fahlström M, Werner S, Forssblad M, Willberg L. Evaluation of Achilles and patellar tendinopathy with greyscale ultrasound and colour Doppler: using a four-grade scale. Knee Surg Sports Traumatol Arthrosc 2016; 24 (06) 1988-1996
    CrossrefPubMedGoogle Scholar
  • 22 Buonocore D, Rucci S, Vandoni M, Negro M, Marzatico F. Oxidative system in aged skeletal muscle. Muscles Ligaments Tendons J 2012; 1 (03) 85-90
    PubMedGoogle Scholar
  • 23 Fu SC, Yeung MY, Rolf CG, Yung PS, Chan KM, Hung LK. Hydrogen peroxide induced tendinopathic changes in a rat model of patellar tendon injury. J Orthop Res 2018; 36 (12) 3268-3274
    CrossrefPubMedGoogle Scholar
  • 24 Guaraldo SA, Serra AJ, Amadio EM. et al. The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise. Lasers Med Sci 2016; 31 (05) 833-840
    CrossrefPubMedGoogle Scholar
  • 25 Yuan J, Murrell GA, Trickett A, Wang MX. Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts. Biochim Biophys Acta 2003; 1641 (01) 35-41
    CrossrefPubMedGoogle Scholar
  • 26 Lee YW, Fu SC, Yeung MY, Lau CML, Chan KM, Hung LK. Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells. Oxid Med Cell Longev 2017; 2017: 8785042
    PubMedGoogle Scholar
  • 27 Sun W, Meng J, Wang Z. et al. Proanthocyanidins Attenuation of H2O2-Induced Oxidative Damage in Tendon-Derived Stem Cells via Upregulating Nrf-2 Signaling Pathway. BioMed Res Int 2017; 2017: 7529104
    PubMedGoogle Scholar
  • 28 Chen H, Ge HA, Wu GB, Cheng B, Lu Y, Jiang C. Autophagy Prevents Oxidative Stress-Induced Loss of Self-Renewal Capacity and Stemness in Human Tendon Stem Cells by Reducing ROS Accumulation. Cell Physiol Biochem 2016; 39 (06) 2227-2238
    CrossrefPubMedGoogle Scholar
  • 29 Tamae K, Eto T, Aoki K. et al. Analyses of associations between reactive oxygen metabolites and antioxidant capacity and related factors among healthy adolescents. Curr Aging Sci 2013; 6 (03) 258-265
    CrossrefPubMedGoogle Scholar
  • 30 McAuliffe S, McCreesh K, Culloty F, Purtill H, O'Sullivan K. Can ultrasound imaging predict the development of Achilles and patellar tendinopathy? A systematic review and meta-analysis. Br J Sports Med 2016; 50 (24) 1516-1523
    CrossrefPubMedGoogle Scholar
  • 31 Stepanyan V, Crowe M, Haleagrahara N, Bowden B. Effects of vitamin E supplementation on exercise-induced oxidative stress: a meta-analysis. Appl Physiol Nutr Metab 2014; 39 (09) 1029-1037
    CrossrefPubMedGoogle Scholar