Thromb Haemost 2021; 121(05): 650-658
DOI: 10.1055/s-0040-1721144
Atherosclerosis and Ischaemic Disease

Circulating Amyloid Beta 1–40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study

Irene Lambrinoudaki*
1  Menopause Clinic, 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Dimitrios Delialis*
2  Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
,
Georgios Georgiopoulos*
2  Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
3  School of Biomedical Engineering & Imaging Sciences, Rayne Institute, St. Thomas' Hospital, London, United Kingdom
,
Simon Tual-Chalot
4  Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
,
Nikolaos I. Vlachogiannis
4  Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
,
Raphael Patras
2  Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
,
Evmorfia Aivalioti
2  Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
,
Eleni Armeni
1  Menopause Clinic, 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Areti Augoulea
1  Menopause Clinic, 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Nikolaos Tsoltos
1  Menopause Clinic, 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Anastasia Soureti
1  Menopause Clinic, 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Konstantinos Stellos**
4  Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
5  Department of Cardiology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
,
Kimon Stamatelopoulos**
1  Menopause Clinic, 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece
4  Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
› Author Affiliations
Funding K. Stellos is supported by grants from the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Program (grant agreement No. 759248) and the DFG (SFB834 project number 75732319).

Abstract

Background Accumulating evidence suggests that circulating amyloidβ 1–40 (Αβ1–40), a proatherogenic aging peptide, may serve as a novel biomarker in cardiovascular disease (CVD). We aimed to explore the role of plasma Αβ1–40 and its patterns of change over time in atherosclerosis progression in postmenopausal women, a population with substantial unrecognized CVD risk beyond traditional risk factors (TRFs).

Methods In this prospective study, Αβ1–40 was measured in plasma by enzyme-linked immunosorbent assay and atherosclerosis was assessed using carotid high-resolution ultrasonography at baseline and after a median follow-up of 28.2 months in 152 postmenopausal women without history or symptoms of CVD.

Results At baseline, high Αβ1–40 was independently associated with higher carotid bulb intima-media thickness (cbIMT) and the sum of maximal wall thickness in all carotid sites (sumWT) (p < 0.05). Αβ1–40 levels increased over time and were associated with decreasing renal function (p < 0.05 for both). Women with a pattern of increasing or persistently high Αβ1–40 levels presented accelerated progression of cbIMT and maximum carotid wall thickness and sumWT (p < 0.05 for all) after adjustment for baseline Αβ1–40 levels, TRFs, and renal function.

Conclusion In postmenopausal women, a pattern of increasing or persistently high Αβ1–40 was associated with the rate of progression of subclinical atherosclerosis irrespective of its baseline levels. These findings provide novel insights into a link between Αβ1–40 and atherosclerosis progression in menopause and warrant further research to clarify the clinical value of monitoring its circulating levels as an atherosclerosis biomarker in women without clinically overt CVD.

* The first three authors contributed equally to this work.


** Equal senior authorship.


Supplementary Material



Publication History

Received: 17 June 2020

Accepted: 10 October 2020

Publication Date:
17 November 2020 (online)

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