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Vet Comp Orthop Traumatol 2021; 34(03): 206-213
DOI: 10.1055/s-0040-1719167
Original Research

Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Dogs

Yaiza Herrero
1   Division of Emergency and Critical Care Medicine, Department of Small Animals, Vetsuisse Faculty of the University of Zurich, Zurich, Switzerland
,
Rahel Jud Schefer
1   Division of Emergency and Critical Care Medicine, Department of Small Animals, Vetsuisse Faculty of the University of Zurich, Zurich, Switzerland
,
Benjamin M. Muri
2   Clinic for Small Animal Surgery, Department of Small Animals, Vetsuisse Faculty of the University of Zurich, Zurich, Switzerland
,
Nadja E. Sigrist 
1   Division of Emergency and Critical Care Medicine, Department of Small Animals, Vetsuisse Faculty of the University of Zurich, Zurich, Switzerland
› Author Affiliations Funding This study was partly funded by the Small Animal Foundation of the Vetsuisse Faculty (Intern salary and ROTEM material), and Axonlab AG, Baden, Switzerland (discount on ROTEM material)
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Abstract

Objective The aim of this study was to describe the coagulation status of traumatized dogs over the first 24 hours after admission.

Study Design In 33 dogs presenting within 6 hours after trauma blood was sampled for rotational thromboelastometry (ROTEM), thrombocyte number and venous blood gas analysis at presentation and 6 and 24 hours thereafter. At each time point, dogs were defined as hypo-, normo- or hypercoagulable based on extrinsic, intrinsic and fibrinogen ROTEM profiles.

Results Significantly more dogs (11/33) presented hypocoagulable compared with 6 hours (p = 0.046) and 24 hours (p = 0.008) thereafter and none presented hypercoagulable. Significantly more dogs were hypercoagulable (6/23, p = 0.014) and no dog was hypocoagulable at 24 hours compared with presentation. All evaluated ROTEM parameters except maximum lysis were significantly more hypocoagulable at presentation compared with 24 hours thereafter.

Conclusion Hypocoagulability is more common in acutely traumatized dogs than previously described. Dogs were hypo- or normocoagulable at presentation and the coagulation status changed to normo- or hypercoagulability over the first 24 hours. Clotting times, clot formation and clot firmness but not clot lysis were significantly altered at presentation compared with 24 hours and fibrinogen concentration or function may play an important role in the dynamic change of coagulation state over time.

Keywords

coagulation - canine - hypercoagulopathy - ATC - acute traumatic coagulopathy

Note

This study was presented in part as a poster at the 17th European Veterinary Emergency and Critical Care congress in Venice, Italy, June 21, 2018.


Authors' Contributions

All authors contributed to conception of study, study design, acquisition of data, data analysis and interpretation, and drafting/revising and approving the submitted manuscript. They drafted/revised and approved the submitted manuscript. They are publically accountable for relevant content.




Publication History

Received: 10 February 2020

Accepted: 30 September 2020

Article published online:
17 November 2020

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