CC BY-NC-ND 4.0 · Revista Chilena de Ortopedia y Traumatología 2020; 61(03): 108-111
DOI: 10.1055/s-0040-1719021
Case Report | Relato de Caso

Metástasis bilateral de húmero, en paciente con cáncer renal, tratado con inmunoterapia y cirugía. Reporte de un caso

Bilateral Humeral Metastases, in a Patient with Renal Cancer, Treated with Immunotherapy and Surgery. Case Report
1   Hospital Clínico Mutual de Seguridad CChC, Santiago, 13 Región Metropolitana, Chile
,
1   Hospital Clínico Mutual de Seguridad CChC, Santiago, 13 Región Metropolitana, Chile
,
Roberto Montegu
2   Equipo de Hombro y Codo, Servicio de Traumatología, Clínica Red Salud Providencia, Chile
,
Juan Pablo Rieutord
2   Equipo de Hombro y Codo, Servicio de Traumatología, Clínica Red Salud Providencia, Chile
› Institutsangaben

Resumen

El carcinoma de células renales es el 7mo cáncer en frecuencia a nivel mundial con más de 300.000 casos nuevos al año y es la 3era malignidad genitourinaria más frecuente.

El sitio más común de metástasis es el pulmón mientras que el esqueleto ocupa el segundo lugar con una frecuencia que varía entre un 20% a un 35%. Se ha reportado una sobrevida de 12 meses en promedio luego de la aparición de metástasis óseas.

Reporte del caso de un paciente con diagnóstico de cáncer renal de células claras y metástasis óseas (en columna, pelvis y ambos húmeros), que evoluciona con fractura de ambos brazos. El paciente es aceptado en un ensayo clínico de tratamiento con inmunoterapia y además se somete a una reducción y osteosíntesis bilateral de húmero con clavo endomedular, logrando la consolidación de ambas fracturas y, por ende, la regresión de la enfermedad.

Abstract

Renal cell carcinoma is ranked 7th in frequent cancer worldwide with more than 3000.000 new cases per year, as well as it's ranked 3rd in frequent genitourinary malignancy.

The most common area of metastases is lung followed by skeleton in second place. The frequency of skeleton metastases varies from 20% to 35%. A survival average time of 12 months is generally observed after the appearance of bone metastases.

This case report is about a patient diagnosed with clear cell renal cancer and bone metastases (in the spine, pelvis and both humerus) that evolves with fracture of both arms. The patient undergoes a clinical trial with immunotherapy and also a reduction and osteosynthesis of both arms with intramedullary nail, achieving consolidation of both fractures and regression of the disease.



Publikationsverlauf

Eingereicht: 05. Juni 2020

Angenommen: 25. August 2020

Artikel online veröffentlicht:
24. November 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • Referencias

  • 1 Ferlay J, Soerjomataram I, Dikshit R. , et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136 (05) E359-E386
  • 2 Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66 (01) 7-30
  • 3 Woodward E, Jagdev S, McParland L. , et al. Skeletal complications and survival in renal cancer patients with bone metastases. Bone 2011; 48 (01) 160-166
  • 4 Patard JJ, Leray E, Rioux-Leclercq N. , et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol 2005; 23 (12) 2763-2771
  • 5 Szendroi A, Dinya E, Kardos M. , et al. Prognostic factors and survival of renal clear cell carcinoma patients with bone metastases. Pathol Oncol Res 2010; 16 (01) 29-38
  • 6 Lipton A, Colombo-Berra A, Bukowski RM, Rosen L, Zheng M, Urbanowitz G. Skeletal complications in patients with bone metastases from renal cell carcinoma and therapeutic benefits of zoledronic acid. Clin Cancer Res 2004; 10 (18 Pt 2): 6397S-6403S
  • 7 Toyoda Y, Shinohara N, Harabayashi T. , et al. Survival and prognostic classification of patients with metastatic renal cell carcinoma of bone. Eur Urol 2007; 52 (01) 163-168
  • 8 Flanigan RC, Campbell SC, Clark JI, Picken MM. Metastatic renal cell carcinoma. Curr Treat Options Oncol 2003; 4 (05) 385-390
  • 9 Casadei R, Drago G, Di Pressa F, Donati D. Humeral metastasis of renal cancer: Surgical options and review of literature. Orthop Traumatol Surg Res 2018; 104 (04) 533-538
  • 10 Guidelines on renal cell carcinoma. European Association of Urology, 2017. cited 2017 Dec 30. Available from: http://www.uroweb.org/guideline/renal-cell-carcinoma
  • 11 Zekri J, Ahmed N, Coleman RE, Hancock BW. The skeletal metastatic complications of renal cell carcinoma. Int J Oncol 2001; 19 (02) 379-382
  • 12 Pretell J, Rodriguez J, Blanco D, Zafra A, Resines C. Treatment of pathological humeral shaft fractures with intramedullary nailing. A retrospective study. Int Orthop 2010; 34 (04) 559-563
  • 13 Sarahrudi K, Wolf H, Funovics P, Pajenda G, Hausmann JT, Vécsei V. Surgical treatment of pathological fractures of the shaft of the humerus. J Trauma 2009; 66 (03) 789-794
  • 14 Moura DL, Alves F, Fonseca R, Freitas J, Casanova J. Treatment of Pathological Humerus-Shaft Tumoral Fractures with Rigid Static Interlocking Intramedullary Nail-22 Years of Experience. Rev Bras Ortop (Sao Paulo) 2019; 54 (02) 149-155
  • 15 Sharma B, Kapoor K, Verma R. Presentation and management of bilateral fracture shaft humerus in a multiple myeloma patient: An extremely rare case report and review of literature. Indian Journal of Case Reports 2018; 4 (03) 214-217
  • 16 Dijkstra S, Stapert J, Boxma H, Wiggers T. Treatment of pathological fractures of the humeral shaft due to bone metastases: a comparison of intramedullary locking nail and plate osteosynthesis with adjunctive bone cement. Eur J Surg Oncol 1996; 22 (06) 621-626
  • 17 Piccioli A, Maccauro G, Rossi B, Scaramuzzo L, Frenos F, Capanna R. Surgical treatment of pathologic fractures of humerus. Injury 2010; 41 (11) 1112-1116
  • 18 Capanna R, Campanacci DA. The treatment of metastases in the appendicular skeleton. J Bone Joint Surg Br 2001; 83 (04) 471-481
  • 19 Bayram S, Özmen E, Birişik F, Kıral D, Salduz A, Erşen A. Prognostic factors affecting survival of patients with pathologic humerus shaft fractures treated with intramedullary nailing without tumor removal. J Orthop Sci 2019; 24 (06) 1068-1073
  • 20 Szendrői M, Antal I, Szendrői A, Lazáry Á, Varga PP. Diagnostic algorithm, prognostic factors and surgical treatment of metastatic cancer diseases of the long bones and spine. EFORT Open Rev 2017; 2 (09) 372-381
  • 21 Bickels J, Kollender Y, Wittig JC, Meller I, Malawer MM. Function after resection of humeral metastases: analysis of 59 consecutive patients. Clin Orthop Relat Res 2005; (437) 201-208
  • 22 Thai DM, Kitagawa Y, Choong PF. Outcome of surgical management of bony metastases to the humerus and shoulder girdle: a retrospective analysis of 93 patients. Int Semin Surg Oncol 2006; 3: 5
  • 23 Wedin R, Hansen BH, Laitinen M. , et al. Complications and survival after surgical treatment of 214 metastatic lesions of the humerus. J Shoulder Elbow Surg 2012; 21 (08) 1049-1055
  • 24 Alexa O, Veliceasa B. Multiple myeloma with bilateral humerus location. Case report. Rev Med Chir Soc Med Nat Iasi 2013; 117 (01) 160-164