CC BY-NC-ND 4.0 · Journal of Cardiac Critical Care TSS 2020; 4(02): 163-164
DOI: 10.1055/s-0040-1718984
Letter to the Editor

Is It Necessary to Apply Neuroprotective Methods after Cardiac Arrest?

Calixto Machado
1  Department of Clinical Neurophysiology, Institute of Neurology and Neurosurgery, Havana, Cuba
2  Faculty of Social Welfare and Health Sciences, University of Haifa, Israel
3  Department of Neurology, University of the Medical Sciences, Havana, Cuba
› Author Affiliations

To the Editor,

Cour et al[1] [2] have analyzed risk factors in patients effectively resuscitated out-of-hospital cardiac arrest (OHCA) who progress to brain death (BD). Their study found that in those cases, resuscitated OHCA with predominantly nonshockable initial rhythms was independently associated with the following five simple risk factors associated with progression toward BD: female gender, young age, neurologic cause of cardiac arrest, duration of low-flow period, and persistent hemodynamic shock. These were independently associated with BD. The authors concluded that these factors might assist in the early recognition of a probable pool of future organ donors.[3] Nonetheless, we require employment of neuroprotection methods to those cases suffering from OHCA or even from intrahospital cardiac arrests.[3]

Hypothermia is the best-known method to protect the brain and bodily organs against the effects ischemia and anoxia.[4] The advantage of hypothermia treatment has also been supported by reports of patients suffering from accidental hypothermia (e.g., immersion/submersion in cold water, snow avalanche, or prolonged exposure to cold surroundings) combined with circulatory arrest or severe circulatory failure during long periods of time. When these patients were rewarmed to normothermia by use of extracorporeal circulation, good outcome in several cases has been reported.[5] [6] The key point in these cases is that the neuroprotective effect occurred early, before a complete cardiac arrest had occurred.

Our commentary concerns the effects of hypoxia and ischemia on the brain after cardiac arrest. The human brain uses approximately 20% of the cardiac cycle, allowing cerebral blood flow (CBF) to be tightly regulated to meet the brain’s metabolic demands. The CBF dropping to less than 20 mL/100 gm/minute produces ischemic neuronal activity reduction but still reversible neuronal changes. CBF values less than 10mL/100 gm/minute result in irreversible ischemic neuronal damage within minutes, as reflected by membrane failure.7 That’s why the CBF values between 10 and 20 mL/100 gm/minute are considered the ischemic penumbra, reflecting neuronal tissue that may potentially be rescued.[3] [7] [8]

Even when resuscitation in cardiac arrest is successful, recovery is too often limited by anoxic encephalopathy. This complication increases with delay in resuscitation, and then the prognosis for comatose survivors of cardiac arrest is frequently poor.[3]

Several research groups have developed protocols for lowering body temperature in comatose survivors of cardiac arrest, resulting in a significant improvement in neurologic outcome. Safar8 documented in dog experimental models of prolonged exsanguination brain and organ preservation during cardiac arrest (no-flow) durations for up to 120 minutes. They noted that it is logical for mild hypothermia to be used in focal ischemic insults such as stroke, where it could play a neuroprotective role, but noted that reperfusion was critical in that condition, and hypothermia should serve as a bridge and/or adjunct in that regard. They stated that the plumbing must be addressed in stroke, otherwise acute therapies cannot be effective.[9]

Risk factors aiding clinicians in the prognosis of patients after OHCA are quite simple to determine.1 It is necessary to develop and apply neuroprotective methods to prevent brain damage due to anoxia and ischemia, initiated as soon as possible after cardiac arrest and maintained even during cardiopulmonary resuscitation.[3]

Publication History

Publication Date:
18 October 2020 (online)

© 2020. Official Publication of The Simulation Society (TSS), accredited by International Society of Cardiovascular Ultrasound ISCU. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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