Semin Thromb Hemost 2021; 47(04): 351-361
DOI: 10.1055/s-0040-1718402
Review Article

Presenting Characteristics, Treatment Patterns, and Outcomes among Patients with Venous Thromboembolism during Hospitalization for COVID-19

Carmen Fernández-Capitán
1  Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
,
Raquel Barba
2  Department of Internal Medicine, Hospital Rey Juan Carlos, Madrid, Spain
,
María del Carmen Díaz-Pedroche
3  Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain
,
Patricia Sigüenza
4  Department of Internal Medicine, Hospital Germans Trias I Pujol, Badalona, Barcelona, Spain
,
Pablo Demelo-Rodriguez
5  Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Carmine Siniscalchi
6  Department of Internal and Emergency Medicine, Angiology Unit, Parma University Hospital, Parma, Italy
,
José María Pedrajas
7  Department of Internal Medicine, Hospital Clínico San Carlos, Madrid, Spain
,
Ana I. Farfán-Sedano
8  Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain
,
Pavel Eduardo Olivera
9  Department of Hematology, Hospital Universitari Sagrat Cor, Barcelona, Spain
,
Covadonga Gómez-Cuervo
10  Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain
,
Pilar Llamas
11  Department of Hematology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
,
Paula Villares
12  Department of Internal Medicine, Hospital de Madrid Norte Sanchinarro. Madrid, Spain
,
Olivier Sanchez
13  Department of Pneumonology, Hôpital Europeen Georges Pompidou, Paris, France
,
Raquel López-Reyes
14  Department of Pneumonology, Hospital Universitari i Politècnic La Fe, Valencia, Spain
,
Judith Catella
15  Department of Internal Medicine, Hôpital Édouard Herriot, Lyon, France
,
Behnood Bikdeli
16  Department of Cardiology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
17  Department of Cardiology, Yale/YNHH Center for Outcomes Research & Evaluation, New Haven, Connecticut
18  Department of Cardiology, Cardiovascular Research Foundation, New York, New York
,
Ido Weinberg
19  Department of Cardiology, Massachusetts General Hospital, Boston, Massachusetts
,
Alfonso J. Tafur
20  Department of Medicine and Vascular Medicine, Evanston NorthShore University Health System, Evanston, Illinois
,
David Jiménez
21  Respiratory Department, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain
22  Medicine Department, Universidad de Alcalá (IRYCIS), Madrid, Spain
23  CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
,
Manuel Monreal
24  Department of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
25  Catedra de enfermedad tromboembólica, Universidad Católica de Murcia, Spain
26  CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain
› Author Affiliations
Funding This study was supported by Sanofi Spain with an unrestricted educational grant. The funders had no role in the design, conduct, or analyses, or the decision to submit this study.

Abstract

Venous thromboembolism (VTE) is common in patients with coronavirus disease-2019 (COVID-19). However, limited data exist on patient characteristics, treatments, and outcomes. To describe the clinical characteristics, treatment patterns, and short-term outcomes of patients diagnosed with VTE during hospitalization for COVID-19. This is a prospective multinational study of patients with incident VTE during the course of hospitalization for COVID-19. Data were obtained from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry. All-cause mortality, VTE recurrences, and major bleeding during the first 10 days were separately investigated for patients in hospital wards versus those in intensive care units (ICUs). As of May 03, 2020, a total number of 455 patients were diagnosed with VTE (83% pulmonary embolism, 17% isolated deep vein thrombosis) during their hospital stay; 71% were male, the median age was 65 (interquartile range, 55–74) years. Most patients (68%) were hospitalized in medical wards, and 145 in ICUs. Three hundred and seventeen (88%; 95% confidence interval [CI]: 84–91%) patients were receiving thromboprophylaxis at the time of VTE diagnosis. Most patients (88%) received therapeutic low-molecular-weight heparin, and 15 (3.6%) received reperfusion therapies. Among 420 patients with complete 10-day follow-up, 51 (12%; 95% CI: 9.3–15%) died, no patient recurred, and 12 (2.9%; 95% CI: 1.6–4.8%) experienced major bleeding. The 10-day mortality rate was 9.1% (95% CI: 6.1–13%) among patients in hospital wards and 19% (95% CI: 13–26%) among those in ICUs. This study provides characteristics and early outcomes of patients diagnosed with acute VTE during hospitalization for COVID-19. Additional studies are needed to identify the optimal strategies to prevent VTE and to mitigate adverse outcomes associated.

* A full list of RIETE investigators is given in Appendix 1.




Publication History

Publication Date:
21 October 2020 (online)

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