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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2021; 56(04): 470-477
DOI: 10.1055/s-0040-1716764
Artigo Original
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Treatment of Chondral Knee Lesions with Autologous Chondrocytes Embedded in a Fibrin Scaffold. Clinical and Functional Assessment[*]

Article in several languages: português | English
Eduardo Alvarez-Lozano 
1   Departamento de Cirurgia Ortopédica, Hospital Jose E Gonzalez, Universidad Autonóma de Nuevo Leon, Monterrey, México
,
Herminia Martinez-Rodriguez 
2   Departamento de Bioquímica, Universidad Autonóma de Nuevo Leon, Monterrey, México
,
Francisco Forriol 
3   Facultad de Medicina, Universidade San Pablo CEU, IMMA, Boadilla del Monte, Madri, Espanha
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Abstract

Objective The aim of our study is to analyze the clinical and functional results obtained using autologous chondrocytes embedded in a fibrin scaffold in knee joint injuries.

Methods We included 56 patients, 36 men and 20 women, with a mean age 36 years. Six of the patients were professional athletes, with single knee injuries that were either chondral or osteochondral (43 chondral, 9 osteochondral, 2 cases of osteochondritis dissecans and 2 osteochondral fractures), 2 to 10 cm2 in size and ≤ 10 mm deep, with no signs of osteoarthritis. The location of the injury was in the patella (8), the medial femoral condyle (40) and lateral femoral condyle (7) and one in the trochlea. The mean follow-up was 3 (range: 1–6) years. The clinical course was assessed using the Cincinnati and Knee Injury and Osteoarthritis Outcome (KOOS) scores, 6 and 12 months after surgery. The paired Student t-test was used to compare pre-and postoperative results.

Results Six months after the implant, patients resumed their everyday activities. On the assessment scores, their condition was improving in comparison with their presurgical state (p < 0.05). They were also able to carry out their sporting activities more easily than prior to surgery (p < 0.05).

Conclusion The seeding of chondrocytes in fibrin may provide a favorable micro-environment for the synthesis of extracellular matrix and improved the clinical condition and activity of the patients 1 year after surgery.

Keywords

cartilage - knee - scaphoid bone - chondrocytes - fibrin

Financial Support

There was no financial support from public, commercial, or non-profit sources.


* Work developed at the CEU-San Pablo University School of Medicine, IMMA, Boadilla del Monte, Madrid, Spain.




Publication History

Received: 05 January 2020

Accepted: 06 July 2020

Article published online:
29 October 2020

© 2020. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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