Drug-Induced Lupus Erythematosus Associated with Proton Pump Inhibitor

Abstract

Drug-induced lupus erythematosus is an autoimmune phenomenon where the drug exposure leads to the development of systemic lupus erythematous like clinical features. Drug-induced lupus erythematosus can be divided into systemic lupus erythematous, subacute cutaneous lupus erythematous, and chronic cutaneous lupus erythematous. Here, we report a case of a 29-year-old female presented with systemic lupus erythematous due to chronic use of proton pump inhibitors, which is considered to be very rare.

Keywords

drug-induced lupus - pantoprazole - proton pump inhibitors

Publikationsverlauf

Artikel online veröffentlicht:
08. September 2020

• References

• 1 Hess E. Drug-related lupus. N Engl J Med 1988; 318 (22) 1460-1462
• 2 Hoffman BJ. Sensitivity to sulfadiazine resembling acute disseminated lupus erythematosus. Arch Derm Syphilol 1945; 51: 190-192
• 3 Dam C, Bygum A. Subacute cutaneous lupus erythematosus induced or exacerbated by proton pump inhibitors. Acta Derm Venereol 2008; 88 (01) 87-89
• 4 Yoshimasu T, Hiroi A, Uede K, Furukawa F. Discoid lupus erythematosus (DLE)-like lesion induced by uracil-tegafur (UFT). Eur J Dermatol 2001; 11 (01) 54-57
• 5 Pramatarov KD. Drug-induced lupus erythematosus. Clin Dermatol 1998; 16 (03) 367-377
• 6 Antonov D, Kazandjieva J, Etugov D, Gospodinov D, Tsankov N. Drug-induced lupus erythematosus. Clin Dermatol 2004; 22 (02) 157-166
• 7 Sandholdt LH, Laurinaviciene R, Bygum A. Proton pump inhibitor-induced subacute cutaneous lupus erythematosus. Br J Dermatol 2014; 170 (02) 342-351
• 8 Solhjoo M, Ho CH, Chauhan K, Gossman W. Drug-Induced Lupus Erythematosus. Treasure Island: StatPearls Publishing; 2019