Abstract
Introduction Schwannomas represent benign peripheral nerve sheath tumors. Their phenotypic presentations
in schwannomatosis and segmental schwannomatosis have been well described. To date,
however, cases of schwannomatosis or multiple schwannomas localized to a single nerve
fascicle have been limited in the literature.
Case Presentation In this study, we identify a case of a 48 year-old non-neurofibromatosis male who
presented with symptomatic schwannomas localized to a single nerve fascicle of the
upper extremity. Intraoperative exploration revealed four schwannomas arising from
a 15-cm segment of ulnar nerve fascicle. Surgical excision was successful, without
neurological deficit or recurrence.
Conclusion This study identifies a case of schwannomatosis localized to a single nerve fascicle
that may represent a linear variant of segmental schwannomatosis. The presentation
may represent a temporary linear appearance in progression to “nonlinear” segmental
variant; however, a molecularly distinct subset of schwannomas cannot be excluded.
Keywords
schwannoma - peripheral nerve sheath tumor - schwannomatosis - upper extremity
