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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2021; 25(03): e443-e445
DOI: 10.1055/s-0040-1715151
Original Research

Tympanic Membrane Retractions in patients with Williams Syndrome: A Controlled Study

Marcelo Wierzynski Oliveira 
1   Department of Otolaryngology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Joel Lavinsky 
2   Department of Morphological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
3   Santa Casa de Misericordia de Porto Alegre, Porto Alegre, RS, Brazil
,
Marcel Machado Valerio 
4   School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Temis Maria Felix 
5   Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Luiz Lavinsky 
1   Department of Otolaryngology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Abstract

Introduction The role of elastin in tympanic retractions and chronic otitis media is not well established. Williams Syndrome (WS), a pathology related to a mutation in the elastin gene, could generate tympanic retractions.

Objective To compare the prevalence of tympanic retractions among patients with WS and controls.

Methods WS patients (n = 43 ears) and controls (n = 130 ears) were evaluated by digital otoscopic examination and the degree of tympanic membrane retraction was classified by 2 blinded experienced otolaryngologists.

Results The agreement rate between the evaluators was 71.1% for pars tensa and 65% for pars flaccida retraction (p < 0.001). The pars tensa and pars flaccida retractions are present in patients with WS after an adjusted residue of respectively - 2.8 and - 2.6 (p = 0.011 and p = 0.022) compared with controls.

Conclusions Tympanic membrane retractions are not more common in the WS group when compared with controls.

Keywords

williams syndrome - elastin - chronic otitis media


Publication History

Received: 08 April 2020

Accepted: 25 June 2020

Article published online:
15 October 2020

© 2020. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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