Semin Respir Crit Care Med 2021; 42(01): 145-159
DOI: 10.1055/s-0040-1714386
Review Article

Life-Threatening Hemoptysis

Himanshu Deshwal
1   Division of Pulmonary, Critical Care and Sleep Medicine, New York University Robert I Grossman School of Medicine, New York, New York
,
Ankur Sinha
2   Division of Pulmonary and Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York
,
Atul C. Mehta
3   Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic Foundation, Cleveland, Ohio
› Institutsangaben

Abstract

Life-threatening hemoptysis (LTH) is any amount of hemoptysis that causes significant hemodynamic decompensation or respiratory distress which may lead to death if left untreated. While the amount of hemoptysis that qualifies as massive hemoptysis has continued to be debated, any amount between 100 to 1,000 mL/day is considered significant. Up to 15% cases of hemoptysis are LTH and need urgent life-saving intervention. Understanding of pulmonary vascular anatomy is of paramount importance to manage LTH. The goal of treatment lies in airway protection, appropriate oxygenation, and prevention of exsanguination. Once the airway is stabilized, a quick diagnosis and control of bleeding site is targeted. This chapter highlights current practices and approach to LTH including medical management, bronchoscopic approach, and advanced therapies such as bronchial artery embolization and surgical resection. We review situations, such as bronchiectasis, vascular malformation, diffuse alveolar hemorrhage, and tracheostomy bleed and specific approach to management of these conditions in a systematic and evidence-based manner.



Publikationsverlauf

Artikel online veröffentlicht:
30. August 2020

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  • References

  • 1 Jeudy J, Khan AR, Mohammed TL. et al; Expert Panel on Thoracic Imaging. ACR Appropriateness Criteria hemoptysis. J Thorac Imaging 2010; 25 (03) W67-9
  • 2 Sakr L, Dutau H. Massive hemoptysis: an update on the role of bronchoscopy in diagnosis and management. Respiration 2010; 80 (01) 38-58
  • 3 Chun JY, Morgan R, Belli AM. Radiological management of hemoptysis: a comprehensive review of diagnostic imaging and bronchial arterial embolization. Cardiovasc Intervent Radiol 2010; 33 (02) 240-250
  • 4 Ibrahim WH. Massive haemoptysis: the definition should be revised. Eur Respir J 2008; 32 (04) 1131-1132
  • 5 Jean-Baptiste E. Clinical assessment and management of massive hemoptysis. Crit Care Med 2000; 28 (05) 1642-1647
  • 6 Hartmann IJ, Remy-Jardin M, Menchini L, Teisseire A, Khalil C, Remy J. Ectopic origin of bronchial arteries: assessment with multidetector helical CT angiography. Eur Radiol 2007; 17 (08) 1943-1953
  • 7 Khalil A, Fartoukh M, Tassart M, Parrot A, Marsault C, Carette MF. Role of MDCT in identification of the bleeding site and the vessels causing hemoptysis. AJR Am J Roentgenol 2007; 188 (02) W117-25
  • 8 Mal H, Rullon I, Mellot F. et al. Immediate and long-term results of bronchial artery embolization for life-threatening hemoptysis. Chest 1999; 115 (04) 996-1001
  • 9 Haponik EF, Britt EJ, Smith PL, Bleecker ER. Computed chest tomography in the evaluation of hemoptysis. Impact on diagnosis and treatment. Chest 1987; 91 (01) 80-85
  • 10 Nielsen K, Gottlieb M, Colella S, Saghir Z, Larsen KR, Clementsen PF. Bronchoscopy as a supplement to computed tomography in patients with haemoptysis may be unnecessary. Eur Clin Respir J 2016; 3: 31802
  • 11 Dellinger RP. Fiberoptic bronchoscopy in adult airway management. Crit Care Med 1990; 18 (08) 882-887
  • 12 Turner JS, Ellender TJ, Okonkwo ER. et al. Feasibility of upright patient positioning and intubation success rates at two academic EDs. Am J Emerg Med 2017; 35 (07) 986-992
  • 13 Lane S, Saunders D, Schofield A, Padmanabhan R, Hildreth A, Laws D. A prospective, randomised controlled trial comparing the efficacy of pre-oxygenation in the 20 degrees head-up vs supine position. Anaesthesia 2005; 60 (11) 1064-1067
  • 14 Kei J, Mebust DP. Comparing the effectiveness of a novel suction set-up using an adult endotracheal tube connected to a meconium aspirator vs. a traditional Yankauer suction instrument. J Emerg Med 2017; 52 (04) 433-437
  • 15 Gourin A, Garzon AA. Control of hemorrhage in emergency pulmonary resection for massive hemoptysis. Chest 1975; 68 (01) 120-121
  • 16 Bair AE, Doherty MJ, Harper R, Albertson TE. An evaluation of a blind rotational technique for selective mainstem intubation. Acad Emerg Med 2004; 11 (10) 1105-1107
  • 17 Valipour A, Kreuzer A, Koller H, Koessler W, Burghuber OC. Bronchoscopy-guided topical hemostatic tamponade therapy for the management of life-threatening hemoptysis. Chest 2005; 127 (06) 2113-2118
  • 18 Campos JH. Which device should be considered the best for lung isolation: double-lumen endotracheal tube versus bronchial blockers. Curr Opin Anaesthesiol 2007; 20 (01) 27-31
  • 19 Freitag L, Tekolf E, Stamatis G, Montag M, Greschuchna D. Three years experience with a new balloon catheter for the management of haemoptysis. Eur Respir J 1994; 7 (11) 2033-2037
  • 20 Dutau H, Palot A, Haas A, Decamps I, Durieux O. Endobronchial embolization with a silicone spigot as a temporary treatment for massive hemoptysis: a new bronchoscopic approach of the disease. Respiration 2006; 73 (06) 830-832
  • 21 Winter SM, Ingbar DH. Massive hemoptysis: pathogenesis and management. J Intensive Care Med 1988; 3: 171-188
  • 22 Amanullah S, Mina B, Rogers M. Iced saline bronchoalveolar lavage –a potential therapeutic option for pulmonary hemorrhage after percutaneous coronary intervention (PCI). Chest 2004; 126: 926S
  • 23 Conlan AA, Hurwitz SS. Management of massive haemoptysis with the rigid bronchoscope and cold saline lavage. Thorax 1980; 35 (12) 901-904
  • 24 Sagar AS, Cherian SV, Estrada-Y-Martin RM. Complete heart block following cold saline lavage during bronchoscopy. J Bronchology Interv Pulmonol 2017; 24 (03) 41-42
  • 25 Zavala DC. Pulmonary hemorrhage in fiberoptic transbronchial biopsy. Chest 1976; 70 (05) 584-588
  • 26 Tuller C, Tuller D, Tamm M, Brutsche MH. Hemodynamic effects of endobronchial application of ornipressin versus terlipressin. Respiration 2004; 71 (04) 397-401
  • 27 Tsukamoto T, Sasaki H, Nakamura H. Treatment of hemoptysis patients by thrombin and fibrinogen-thrombin infusion therapy using a fiberoptic bronchoscope. Chest 1989; 96 (03) 473-476
  • 28 Wand O, Guber E, Guber A, Epstein Shochet G, Israeli-Shani L, Shitrit D. Inhaled tranexamic acid for hemoptysis treatment: a randomized controlled trial. Chest 2018; 154 (06) 1379-1384
  • 29 Dumon JF, Meric B, Surpas P, Ragni J. [Endoscopic resection in bronchology using the YAG laser. Evaluation of a 5-year experience] (in French). Schweiz Med Wochenschr 1985; 115 (39) 1336-1344
  • 30 Khemasuwan D, Mehta AC, Wang K-P. Past, present, and future of endobronchial laser photoresection. J Thorac Dis 2015; 7 (Suppl. 04) S380-S388
  • 31 Han CC, Prasetyo D, Wright GM. Endobronchial palliation using Nd:YAG laser is associated with improved survival when combined with multimodal adjuvant treatments. J Thorac Oncol 2007; 2 (01) 59-64
  • 32 Keller CA, Hinerman R, Singh A, Alvarez F. The use of endoscopic argon plasma coagulation in airway complications after solid organ transplantation. Chest 2001; 119 (06) 1968-1975
  • 33 Morice RC, Ece T, Ece F, Keus L. Endobronchial argon plasma coagulation for treatment of hemoptysis and neoplastic airway obstruction. Chest 2001; 119 (03) 781-787
  • 34 Kızılgöz D, Aktaş Z, Yılmaz A, Öztürk A, Seğmen F. Comparison of two new techniques for the management of malignant central airway obstruction: argon plasma coagulation with mechanical tumor resection versus cryorecanalization. Surg Endosc 2018; 32 (04) 1879-1884
  • 35 Iacopini F, Petruzziello L, Marchese M. et al. Hemostasis of Dieulafoy's lesions by argon plasma coagulation (with video). Gastrointest Endosc 2007; 66 (01) 20-26
  • 36 Ozvaran MK, Baran R, Soğukpmar O. et al. Histopathological diagnosis of endobronchial endometriosis treated with argon laser. Respirology 2006; 11 (03) 348-350
  • 37 Yoon W, Kim JK, Kim YH, Chung TW, Kang HK. Bronchial and nonbronchial systemic artery embolization for life-threatening hemoptysis: a comprehensive review. Radiographics 2002; 22 (06) 1395-1409
  • 38 Marshall TJ, Jackson JE. Vascular intervention in the thorax: bronchial artery embolization for haemoptysis. Eur Radiol 1997; 7 (08) 1221-1227
  • 39 Hayakawa K, Tanaka F, Torizuka T. et al. Bronchial artery embolization for hemoptysis: immediate and long-term results. Cardiovasc Intervent Radiol 1992; 15 (03) 154-158 , discussion 158–159
  • 40 Rabkin JE, Astafjev VI, Gothman LN, Grigorjev YG. Transcatheter embolization in the management of pulmonary hemorrhage. Radiology 1987; 163 (02) 361-365
  • 41 Wong ML, Szkup P, Hopley MJ. Percutaneous embolotherapy for life-threatening hemoptysis. Chest 2002; 121 (01) 95-102
  • 42 Remy J, Lemaitre L, Lafitte JJ, Vilain MO, Saint Michel J, Steenhouwer F. Massive hemoptysis of pulmonary arterial origin: diagnosis and treatment. AJR Am J Roentgenol 1984; 143 (05) 963-969
  • 43 Shigemura N, Wan IY, Yu SC. et al. Multidisciplinary management of life-threatening massive hemoptysis: a 10-year experience. Ann Thorac Surg 2009; 87 (03) 849-853
  • 44 Hirshberg B, Biran I, Glazer M, Kramer MR. Hemoptysis: etiology, evaluation, and outcome in a tertiary referral hospital. Chest 1997; 112 (02) 440-444
  • 45 Knott-Craig CJ, Oostuizen JG, Rossouw G, Joubert JR, Barnard PM. Management and prognosis of massive hemoptysis. Recent experience with 120 patients. J Thorac Cardiovasc Surg 1993; 105 (03) 394-397
  • 46 Flume PA, Yankaskas JR, Ebeling M, Hulsey T, Clark LL. Massive hemoptysis in cystic fibrosis. Chest 2005; 128 (02) 729-738
  • 47 Chatterjee K, Colaco B, Colaco C, Hellman M, Meena N. Rasmussen's aneurysm: A forgotten scourge. Respir Med Case Rep 2015; 16: 74-76
  • 48 Khalil A, Parrot A, Nedelcu C, Fartoukh M, Marsault C, Carette MF. Severe hemoptysis of pulmonary arterial origin: signs and role of multidetector row CT angiography. Chest 2008; 133 (01) 212-219
  • 49 Brinson GM, Noone PG, Mauro MA. et al. Bronchial artery embolization for the treatment of hemoptysis in patients with cystic fibrosis. Am J Respir Crit Care Med 1998; 157 (6 Pt 1): 1951-1958
  • 50 Martin LN, Higgins L, Mohabir P, Sze DY, Hofmann LV. Bronchial artery embolization for hemoptysis in cystic fibrosis patients: a 17-year review. J Vasc Interv Radiol 2019; 31 (02) 331-335
  • 51 Orens JB, Estenne M, Arcasoy S. et al; Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2006; 25 (07) 745-755
  • 52 Margono E, Hoffmann JC. Extreme recurrent massive hemoptysis in a cystic fibrosis patient requiring 22 separate embolization procedures prior to lung transplantation: a case report. Radiol Case Rep 2019; 14 (04) 472-475
  • 53 Park MS. Diffuse alveolar hemorrhage. Tuberc Respir Dis (Seoul) 2013; 74 (04) 151-162
  • 54 Cordier JF, Cottin V. Alveolar hemorrhage in vasculitis: primary and secondary. Semin Respir Crit Care Med 2011; 32 (03) 310-321
  • 55 Specks U. Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol 2001; 13 (01) 12-17
  • 56 Cartin-Ceba R, Diaz-Caballero L, Al-Qadi MO. et al. Diffuse alveolar hemorrhage secondary to antineutrophil cytoplasmic antibody-associated vasculitis: predictors of respiratory failure and clinical outcomes. Arthritis Rheumatol 2016; 68 (06) 1467-1476
  • 57 Solomonov A, Fruchter O, Zuckerman T, Brenner B, Yigla M. Pulmonary hemorrhage: a novel mode of therapy. Respir Med 2009; 103 (08) 1196-1200
  • 58 Pea L, Roda L, Boussaud V, Lonjon B. Desmopressin therapy for massive hemoptysis associated with severe leptospirosis. Am J Respir Crit Care Med 2003; 167 (05) 726-728
  • 59 Marten K, Schnyder P, Schirg E, Prokop M, Rummeny EJ, Engelke C. Pattern-based differential diagnosis in pulmonary vasculitis using volumetric CT. AJR Am J Roentgenol 2005; 184 (03) 720-733
  • 60 Engelke C, Schaefer-Prokop C, Schirg E, Freihorst J, Grubnic S, Prokop M. High-resolution CT and CT angiography of peripheral pulmonary vascular disorders. Radiographics 2002; 22 (04) 739-764
  • 61 Colby TV, Fukuoka J, Ewaskow SP, Helmers R, Leslie KO. Pathologic approach to pulmonary hemorrhage. Ann Diagn Pathol 2001; 5 (05) 309-319
  • 62 Collard HR, Schwarz MI. Diffuse alveolar hemorrhage. Clin Chest Med 2004; 25 (03) 583-592 , vii
  • 63 Leslie KO, Gruden JF, Parish JM, Scholand MB. Transbronchial biopsy interpretation in the patient with diffuse parenchymal lung disease. Arch Pathol Lab Med 2007; 131 (03) 407-423
  • 64 Klemmer PJ, Chalermskulrat W, Reif MS, Hogan SL, Henke DC, Falk RJ. Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis. Am J Kidney Dis 2003; 42 (06) 1149-1153
  • 65 Henke D, Falk RJ, Gabriel DA. Successful treatment of diffuse alveolar hemorrhage with activated factor VII. Ann Intern Med 2004; 140 (06) 493-494
  • 66 Mandal SK, Sagar G, Sahoo M, Jasuja S. Recombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis. Indian J Nephrol 2012; 22 (02) 130-132
  • 67 Baker MS, Diab KJ, Carlos WG, Mathur P. Intrapulmonary recombinant factor VII as an effective treatment for diffuse alveolar hemorrhage: a case series. J Bronchology Interv Pulmonol 2016; 23 (03) 255-258
  • 68 Pacheco Claudio C, Charbonney E, Durand M, Kolan C, Laskine M. Extracorporeal membrane oxygenation in diffuse alveolar hemorrhage secondary to systemic lupus erythematosus. J Clin Med Res 2014; 6 (02) 145-148
  • 69 Muellenbach RM, Kredel M, Kunze E. et al. Prolonged heparin-free extracorporeal membrane oxygenation in multiple injured acute respiratory distress syndrome patients with traumatic brain injury. J Trauma Acute Care Surg 2012; 72 (05) 1444-1447
  • 70 Kolovos NS, Schuerer DJ, Moler FW. et al. Extracorporal life support for pulmonary hemorrhage in children: a case series. Crit Care Med 2002; 30 (03) 577-580
  • 71 Kılıç S, Saraçoğlu E, Alkan G. A rare complication in a patient taking rivaroxaban: Alveolar hemorrhage. Turk Kardiyol Dern Ars 2018; 46 (01) 73-75
  • 72 Hammar SP. Fatal pulmonary hemorrhage after taking anticoagulation medication. Respir Med Case Rep 2015; 15: 66-70
  • 73 Waness A, Aldabbagh T, Harakati M. Diffuse alveolar haemorrhage secondary to warfarin therapy for atrial fibrillation: a case report and literature review. BMJ Case Rep 2009; 2009: bcr08.2008.0757
  • 74 Laird-Fick HGB, Benedict M, Riehani A. Alveolar hemorrhage associated with rivaroxaban: a case series. J Pulm Respir Med 2017; 7: 405
  • 75 Pazzola G, Zuily S, Erkan D. The challenge of bleeding in antiphospholipid antibody-positive patients. Curr Rheumatol Rep 2015; 17 (02) 7
  • 76 Abuqayyas S, Raju S, Bartholomew JR, Abu Hweij R, Mehta AC. Management of antithrombotic agents in patients undergoing flexible bronchoscopy. Eur Respir Rev 2017; 26 (145) 26
  • 77 Raina R, Kaushik M, Mahajan S. et al. Rare interaction of Warfarin and Digoxin in a case of Digoxin toxicity. J Assoc Physicians India 2020; 68 (03) 85-86
  • 78 Samama MM, Contant G, Spiro TE. et al. Laboratory assessment of rivaroxaban: a review. Thromb J 2013; 11 (01) 11
  • 79 Sarode R, Milling Jr TJ, Refaai MA. et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation 2013; 128 (11) 1234-1243
  • 80 Narsinh KH, Ramaswamy R, Kinney TB. Management of pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia patients. Semin Intervent Radiol 2013; 30 (04) 408-412
  • 81 Blei F. Overgrowth syndromes with vascular anomalies. Curr Probl Pediatr Adolesc Health Care 2015; 45 (04) 118-131
  • 82 Denlinger CE, Egan TM, Jones DR. Acquired systemic-to-pulmonary arteriovenous malformation secondary to Mycobacterium tuberculosis empyema. Ann Thorac Surg 2002; 74 (04) 1229-1231
  • 83 Chen W, Chen P, Li X, Gao X, Li J. Clinical characteristics and treatments for bronchial Dieulafoy's disease. Respir Med Case Rep 2019; 26: 229-235
  • 84 Abe J, Hasumi T, Takahashi S, Tanaka R, Sato T, Okazaki T. Fatal broncho-pulmonary artery fistula after lobectomy for lung cancer. J Surg Case Rep 2015; 2015 (09) 1-2
  • 85 Rubin SA, Puckett RP. Pulmonary artery--bronchial fistula: a new complication of Swan-Ganz catheterization. Chest 1979; 75 (04) 515-516
  • 86 Govani FS, Shovlin CL. Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet 2009; 17 (07) 860-871
  • 87 Cottin V, Chinet T, Lavolé A. et al; Groupe d'Etudes et de Recherche sur les Maladies “Orphelines” Pulmonaires (GERM“O”P). Pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: a series of 126 patients. Medicine (Baltimore) 2007; 86 (01) 1-17
  • 88 Santhirapala V, Chamali B, McKernan H. et al. Orthodeoxia and postural orthostatic tachycardia in patients with pulmonary arteriovenous malformations: a prospective 8-year series. Thorax 2014; 69 (11) 1046-1047
  • 89 Barzilai B, Waggoner AD, Spessert C, Picus D, Goodenberger D. Two-dimensional contrast echocardiography in the detection and follow-up of congenital pulmonary arteriovenous malformations. Am J Cardiol 1991; 68 (15) 1507-1510
  • 90 Fang Y, Wu Q, Wang B. Dieulafoy's disease of the bronchus: report of a case and review of the literature. J Cardiothorac Surg 2014; 9: 191
  • 91 Loschhorn C, Nierhoff N, Mayer R, Zaunbauer W, Neuweiler J, Knoblauch A. z. Respiration 2006; 73 (04) 562-565
  • 92 Savale L, Parrot A, Khalil A. et al. Cryptogenic hemoptysis: from a benign to a life-threatening pathologic vascular condition. Am J Respir Crit Care Med 2007; 175 (11) 1181-1185
  • 93 Bhatia P, Hendy MS, Li-Kam-Wa E, Bowyer PK. Recurrent embolotherapy in Dieulafoy's disease of the bronchus. Can Respir J 2003; 10 (06) 331-333
  • 94 Thung KH, Sihoe AD, Wan IY, Lee TW, Wong R, Yim AP. Hemoptysis from an unusual pulmonary arteriovenous malformation. Ann Thorac Surg 2003; 76 (05) 1730-1733
  • 95 Georghiou GP, Berman M, Vidne BA, Saute M. Pulmonary arteriovenous malformation treated by lobectomy. Eur J Cardiothorac Surg 2003; 24 (02) 328-330
  • 96 Patel A, Swan P, Dunning J. Does a percutaneous tracheostomy have a lower incidence of complications compared to an open surgical technique?. Interact Cardiovasc Thorac Surg 2005; 4 (06) 563-568
  • 97 Bradley PJ. Bleeding around a tracheostomy wound: what to consider and what to do?. J Laryngol Otol 2009; 123 (09) 952-956
  • 98 Muhammad JK, Major E, Wood A, Patton DW. Percutaneous dilatational tracheostomy: haemorrhagic complications and the vascular anatomy of the anterior neck. A review based on 497 cases. Int J Oral Maxillofac Surg 2000; 29 (03) 217-222
  • 99 Hung JJ, Hsu HS, Huang CS, Yang KY. Tracheoesophageal fistula and tracheo-subclavian artery fistula after tracheostomy. Eur J Cardiothorac Surg 2007; 32 (04) 676-678
  • 100 Bertelsen S, Jensen NM. Innominate artery rupture. A fatal complication of tracheostomy. Ann Chir Gynaecol 1987; 76 (04) 230-233
  • 101 Ridley RW, Zwischenberger JB. Tracheoinnominate fistula: surgical management of an iatrogenic disaster. J Laryngol Otol 2006; 120 (08) 676-680
  • 102 Utley JR, Singer MM, Roe BB, Fraser DG, Dedo HH. Definitive management of innominate artery hemorrhage complicating tracheostomy. JAMA 1972; 220 (04) 577-579
  • 103 Ghai B, Makkar JK, Bakshi J, Rana S, Singh RS, Bhagat S. Survival of a child without sequelae after tracheoarterial fistula. Paediatr Anaesth 2007; 17 (06) 588-591
  • 104 Hasegawa T, Zaima A, Hisamatsu C, Nishijima E, Okita Y. Minimally invasive innominate artery transection for tracheomalacia using 3-dimensional multidetector-row computed tomographic angiography: report of a case. J Pediatr Surg 2010; 45 (07) E1-E4
  • 105 Sessa C, Costache V, Porcu P. et al. Tracheoinnominate artery fistula: combined endovascular and surgical management by emergency stent-graft placement followed by cryopreserved arterial allograft repair. Ann Vasc Surg 2006; 20 (06) 731-735