ABO Blood Group System and the Association with Cardiovascular Risk Factors between Men and Women with Cardiovascular Diseases—A Comparative Study
Objectives The present study was designed to explore the relation between ABO blood group and cardiovascular risk factors in the patients attending tertiary care hospital in South India.
Materials and Methods One hundred nine patients, each male and female with different cardiovascular diseases, were included in the study and their ABO blood groups were analyzed with the cardiovascular risk factors. A detailed history was taken from all the patients regarding cardiovascular risk factors like high blood pressure, diabetes, and lipidemic. Total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, and serum triglycerides were determined for assessing lipidemia. Blood grouping was done using standard tube technique. Red cell and serum grouping was performed and results documented. Association between ABO blood groups and cardiovascular risk factors was done using chi-square test and Spearman’s correlation.
Results The distribution of ABO blood groups shows that blood group O (41.28%) was more common in patients followed by group B (29.36%), group A (19.27%), and group AB (10.09%). One-hundred six cases (97.2%) were Rh D positive. A statistically significant difference was observed between gender and total cholesterol, LDL cholesterol and BMI with p value <0.05. In the study population, distribution of major cardiovascular risk factors, especially diabetes mellitus and dyslipidaemia, with ABO blood groups shows that there was no significant difference observed between blood groups and these cardiovascular risk factors. However, statistical significance was there between blood group O and hypertension (p = 0.03).
Conclusion There was no significant difference between the blood groups and the major cardiovascular risk factors were diabetes and lipids, but there was an association between blood group O and hypertension.
16 July 2020 (online)
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- 1 Garratty G. Blood groups and disease: a historical perspective. Transfus Med Rev 2000; 14 (04) 291-301
- 2 Jenkins PV, O’Donnell JS. ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?. Transfusion 2006; 46 (10) 1836-1844
- 3 Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications. Thromb J 2007; 5: 14
- 4 Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost 2008; 6 (01) 62-69
- 5 Trégouët D-A, Heath S, Saut N. et al Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood 2009; 113 (21) 5298-5303
- 6 Reilly MP, Li M, He J. et al Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 2011; 377 (9763) 383-392
- 7 Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factors for coronary heart disease. N Engl J Med 1989; 321 (10) 641-646
- 8 Periyavan S, Sangeetha SK, Marimuthu P, Manjunath BK, Seema DM. Distribution of ABO and Rhesus-D blood groups in and around Bangalore. Asian J Transfus Sci 2010; 4 (01) 41
- 9 John S. Prevalence of ABO and Rhesus blood groups in blood donors: a study from a tertiary care centre in South Kerala. Int J Contemporary Med Res 2017; 4 (11) 2314-2316
- 10 Suresh B, Sreedhar Babu KV, Chandra Mouli P, Arun R, Jothibai DS. Distribution of ABO and Rhesus (D) blood group antigens among blood donors at a tertiary care teaching hospital blood bank in south India. J Clin Sci Res 2015; 4: 129-135
- 11 Sahita P, Anand IS, Shah M. Association of ABO blood groups with cardiovascular diseases in adult Indian population. JPTRM 2013; 1 (02) 181-190
- 12 Smith S, Okai I, Abaidoo CS, Acheampong E. Association of ABO blood group and body mass index: a cross-sectional study from a Ghanaian population. J Nutr Metab 2018; 2018: 8050152
- 13 Lutfullah AB, Quraishi NUS, Hanif A, Khan BZ, Bukhshi IM. Association of ABO blood groups and major ischemic heart disease risk factors. Annals of KEMU 2010; 16 (03) 189-193
- 14 Amirzadegan A, Salarifar M, Sadeghian S, Davoodi G, Darabian C, Goodarzynejad H. Correlation between ABO blood groups, major risk factors, and coronary artery disease. Int J Cardiol 2006; 110 (02) 256-258
- 15 Garg P, Kumar J, Choudhary R, Chawla VK. Association between ABO blood groups and myocardial infarction in Jodhpur City of India. J Bangladesh Soc Physiol 2012; 7 (01) 13-17
- 16 Banerjee S, Datta UK. Relationship of ABO blood groups with ischaemic heart disease. Ind Med Gaz 2011; 430-433
- 17 Biswas S, Ghoshal PK, Halder B, Mandal N. Distribution of ABO blood group and major cardiovascular risk factors with coronary heart disease. Biomed Res Int 2013; 2013: 782941
- 18 Madithadu A, Rajendran A, Rajashekar D, Sarella J. Association of coronary artery diseases with ABO and Lewis blood group phenotypes at a tertiary care teaching hospital in southern India. J Clin Diagn Res 2018; 12 (07) 17-21
- 19 Sayed EL, Amin HK. ABO blood groups in correlation with hyperlipidemia, diabetes mellitus type II and essential hypertension. Asian J Pharm Clin Res 2015; 8: 236-242
- 20 Chandra T, Gupta A. Association and distribution of hypertension, obesity and ABO blood groups in blood donors. Iran J Ped Hematol Oncol 2012; 2 (04) 140-145