J Pediatr Intensive Care 2021; 10(02): 106-109
DOI: 10.1055/s-0040-1714098
Original Article

Therapeutic Plasma Exchange Application in Children Requires Individual Decision

Gürkan Atay
1   Department of Pediatric Intensive Care, Faculty of Medicine, Istanbul University, Istanbul, Turkey
,
Demet Demirkol
1   Department of Pediatric Intensive Care, Faculty of Medicine, Istanbul University, Istanbul, Turkey
2   Child Health Institute, Istanbul University, Istanbul, Turkey
› Author Affiliations

Funding None.
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Abstract

Therapeutic plasma exchange (TPE) is a treatment administered with the aim of removing a pathogenic material or compound causing morbidity in a variety of neurologic, hematologic, renal, and autoimmune diseases. In this study, we aimed to assess the indications, efficacy, reliability, complications, and treatment response of pediatric patients for TPE. This retrospective study analyzed data from 39 patients aged from 0 to 18 years who underwent a total of 172 TPE sessions from January 2015 to April 2018 in a tertiary pediatric intensive care unit. Indications for TPE were, in order of frequency, macrophage activation syndrome (28.2%, n = 11), renal transplantation rejection (15.4%, n = 6), liver failure (15.4%, n = 6), Guillain–Barre's syndrome (15%, n = 6), hemolytic uremic syndrome (7.7%, n = 3), acute demyelinating disease (7.7%, n = 3), septic shock (5.1%, n = 2), and intoxication (5.1%, n = 2). No patient had any adverse event related to the TPE during the procedure. The TPE session was ended prematurely in one patient due to insufficient vascular access and lack of blood flow (2.6%). In the long term, thrombosis due to the indwelling central catheter occurred (5.1%, n = 2). TPE appears to be an effective first-stage or supplementary treatment in a variety of diseases, may be safely used in pediatric patients, and there are significant findings that its area of use will increase. In experienced hands and when assessed carefully, it appears that the rate of adverse reactions and vascular access problems may be low enough to be negligible.

Ethical Approval

This study was performed with the approval of the Clinical Research Ethics Committee. Since it was a retrospective case–control study, no informed consent was taken. This article does not contain any studies with animals performed by any of the authors.


Informed Consent

Informed consent was obtained from all individual participants included in the study.




Publication History

Received: 03 April 2020

Accepted: 03 June 2020

Article published online:
20 July 2020

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