Journal of Pediatric Neurology 2021; 19(06): 389-394
DOI: 10.1055/s-0040-1714094
Original Article

Pediatric Neuromuscular Disorders in Ile-Ife, Nigeria: Pattern and the Challenges with Management

1   Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria
,
Abiodun J. Kareem
1   Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria
,
Musa Ayogu
1   Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria
› Author Affiliations
Funding None.

Abstract

The aim of this study was to describe the presentation pattern and challenges with the management of pediatric neuromuscular disorders (NMDs) in Ile-Ife, Nigeria through retrospective review of their clinical records. We recruited 24 children aged 14 days to 15 years with a male preponderance (male-to-female ratio = 2.4:1). Late presentation was a prominent feature which was highest among children with myopathies with a mean duration of symptoms of 46.5 ± 33.4 months before presentation. Peripheral neuropathy was the most common type of NMDs (63.0%). Among these, injection nerve palsy from the use of wrong site for intramuscular injections was the most common (60.0%). Nonavailability of electrophysiologic and genetic testing as well as appropriate medications was the major challenges. Acquired NMDs are common in our setting. There is a need to improve preventive measures of acquired NMDs and early diagnosis of the inherited types.



Publication History

Received: 07 February 2020

Accepted: 29 May 2020

Article published online:
05 August 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Dowling JJ, D Gonorazky H, Cohn RD, Campbell C. Treating pediatric neuromuscular disorders: the future is now. Am J Med Genet A 2018; 176 (04) 804-841
  • 2 Chung B, Wong V, Ip P. Prevalence of neuromuscular diseases in Chinese children: a study in southern China. J Child Neurol 2003; 18 (03) 217-219
  • 3 Darin N, Tulinius M. Neuromuscular disorders in childhood: a descriptive epidemiological study from western Sweden. Neuromuscul Disord 2000; 10 (01) 1-9
  • 4 Emery AEH. Population frequencies of inherited neuromuscular diseases--a world survey. Neuromuscul Disord 1991; 1 (01) 19-29
  • 5 Rose L, McKim D, Leasa D. et al. Trends in incidence, prevalence, and mortality of neuromuscular disease in Ontario, Canada: a population-based retrospective cohort study (2003-2014). PLoS One 2019; 14 (03) e0210574
  • 6 Hughes MI, Hicks EM, Nevin NC, Patterson VH. The prevalence of inherited neuromuscular disease in Northern Ireland. Neuromuscul Disord 1996; 6 (01) 69-73
  • 7 Deenen JC, Horlings CG, Verschuuren JJ, Verbeek AvanEB, van Engelen BG. The epidemiology of neuromuscular disorders: a comprehensive overview of the literature. J Neuromuscul Dis 2015; 2 (01) 73-85
  • 8 Bhatt JM. The epidemiology of neuromuscular diseases. Neurol Clin 2016; 34 (04) 999-1021
  • 9 Merlini L, Stagni SB, Marri E, Granata C. Epidemiology of neuromuscular disorders in the under-20 population in Bologna Province, Italy. Neuromuscul Disord 1992; 2 (03) 197-200
  • 10 Mohamed IN, Elseed MA, Hamed AA. Clinical profile of pediatric neurological disorders. Child Neurol Open 2016; 3: 2329048X1562354
  • 11 Osuntokun BO, Adeuja AO, Schoenberg BS. et al. Neurological disorders in Nigerian Africans: a community-based study. Acta Neurol Scand 1987; 75 (01) 13-21
  • 12 Oyinlade OA, Lagunju IA, Adebayo BE. Neuromuscular disease mimicking myasthenia gravis in a Nigerian female adolescent: could this be nemaline rod disease?. Ann Ib Postgrad Med 2016; 14 (02) 110-113
  • 13 Odinaka KK, Nwolisa EC. Challenges in the management of the child with Duchenne muscular dystrophy in a resource poor setting: a case report. Pan Afr Med J 2014; 19: 227
  • 14 Ajala OA, Olayiwola W. An assessment of the growth of Ile-Ife, Osun State Nigeria, using multitemporal imageries. J Geography Geology 2013; 5 (02) 43
  • 15 Oyedeji GA. Socio economic and cultural background of hospitalized children in Ilesha. Niger J Paediatr 1985; 12: 111-117
  • 16 Kakati A, Bhat D, Devi BI, Shukla D. Injection nerve palsy. J Neurosci Rural Pract 2013; 4 (01) 13-18
  • 17 Theadom A, Rodrigues M, Roxburgh R. et al. Prevalence of muscular dystrophies: a systematic literature review. Neuroepidemiology 2014; 43 (3-4): 259-268