CC BY-NC-ND 4.0 · Eur J Dent 2020; 14(03): 496-501
DOI: 10.1055/s-0040-1713954
Review Article

Corticosteroid Use and Periodontal Disease: A Systematic Review

Rebeca Brasil-Oliveira
1   Postgraduate Program in Medicine and Health, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
,
Álvaro A. Cruz
1   Postgraduate Program in Medicine and Health, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
2   ProAR, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
,
Viviane Almeida Sarmento
3   School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
,
Adelmir Souza-Machado
1   Postgraduate Program in Medicine and Health, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
2   ProAR, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
,
Liliane Lins-Kusterer
1   Postgraduate Program in Medicine and Health, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
› Author Affiliations
Funding This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil–FinanceCode 001 and Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Bahia, Brazilandalsoby Conselho Nacional para o Desenvolvimento Científico e Tecnológico (CNPq), grant 471057/2014–2, Fundação de Amparo à Pesquisa do Estado da Bahia.

Abstract

Periodontitis affects the teeth supporting structures, such as periodontal tissues. We aimed to evaluate the association between periodontal disease and corticosteroid use. We searched in MEDLINE, Web of Sciences, SCOPUS, LILACS, and Cochrane databases, using the descriptors “Periodontal diseases” AND (“adrenal cortex hormones” OR “adrenal cortex hormones” OR (“adrenal” AND “cortex” AND “hormones”) OR “adrenal cortex hormones” OR “corticosteroid”). We selected the summaries of observational studies, addressing periodontal disease in patients using corticosteroids. The search resulted in 403 articles. After applying the selection criteria, eight studies remained; being two retrospective cohorts and six cross-sectional studies. There are few studies with appropriate methodology to produce sound evidence about the causal relationship between the use of corticosteroids and periodontitis. However, two retrospective cohorts confirmed that chronic corticosteroid use is associated with the incidence of periodontal disease. Dental staff must be aware of this association for better management of periodontal disease therapy in patients using corticosteroids.



Publication History

Article published online:
01 July 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • Reference

  • 1 Newman MG, Calmes R. Periodontal disease. Oral Biology. St Louis: CV Mosby Co.; 1981: 369
  • 2 Valente O, Atallah AN. Efeitos metabólicos e manuseio clínico dos corticosteróides. Atualizaçäo terapêutica: manual prático de diagnóstico e tratamento. São Paulo. Art Med 2003; 21: 1710-1712
  • 3 Canalis E, Mazziotti G, Giustina A, Bilezikian JP. Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int 2007; 18 (10) 1319-1328
  • 4 Benedek TG. History of the development of corticosteroid therapy. Clin Exp Rheumatol 2011; 29 (05) (Suppl. 68) S5-S12
  • 5 Bennett PN, Brown MJ. Clinical Pharmacology. 9th ed. New Delhi: Reed Elsevier; 2003: 664
  • 6 Hargitai LI, Sherman CR. Corticosteroids in dentistry. Clin Update 2001; 23: 11-12
  • 7 Yasir M, Goyal A, Bansal P, Sonthalia S. StatPearls. Corticosteroid Adverse Effects. Treasure Island (FL): StatPearls Publishing; 2020
  • 8 Tripathi KD. Essentials of Medical Pharmacology. 6th ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2008
  • 9 Shen TC, Chang PY, Lin CL. et al. Risk of periodontal disease in patients with asthma: a nationwide population-based retrospective cohort study. J Periodontol 2017; 88 (08) 723-730
  • 10 Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol 2007; 78: 1387-1399
  • 11 Leroy R, Eaton KA, Savage A. Methodological issues in epidemiological studies of periodontitis–how can it be improved?. BMC Oral Health 2010; 10: 8
  • 12 Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The PRISMA Statement. Disponívelem: Available at: www.prisma-statement.org. Accessed May 27, 2020
  • 13 Shen TC, Chang PY, Lin CL. et al. Risk of periodontal diseases in patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study. Medicine (Baltimore) 2015; 94 (46) e2047
  • 14 Raj R, Manu MK, Prakash PY, Singhal DK, Acharya S. The effect of 6 months or longer duration of chronic obstructive respiratory disease medication on the oral health parameters of adults. Spec Care Dentist 2018; 38 (03) 133-138
  • 15 Biyikoğlu B, Buduneli N, Kardeşler L, Aksu K, Pitkala M, Sorsa T. Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease. J Periodontol 2009; 80 (08) 1307-1314
  • 16 Biyikoğlu B, Buduneli N, Kardeşler L, Aksu K, Oder G, Kütükçüler N. Evaluation of t-PA, PAI-2, IL-1beta and PGE(2) in gingival crevicular fluid of rheumatoid arthritis patients with periodontal disease. J Clin Periodontol 2006; 33 (09) 605-611
  • 17 Abou-Raya A, Abou-Raya S, Abu-Elkheir H. Periodontal disease and rheumatoid arthritis: is there a link?. Scand J Rheumatol 2005; 34 (05) 408-410
  • 18 Komerik N, Akkaya A, Yildiz M, Buyukkaplan US, Kuru L. Oral health in patients on inhaled corticosteroid treatment. Oral Dis 2005; 11 (05) 303-308
  • 19 Sutton RBO, Smales FC. Cross-sectional study of the effects of immunosuppressive drugs on chronic periodontal disease in man. J Clin Periodontol 1983; 10 (03) 317-326
  • 20 Wells GA, Shea B, O’Çonnell D, Peterson J, Welch V, Losos Metal. The Newcastle-Ottawa Sacale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. 2014. Available at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed May 27, 2020
  • 21 Fabbri C, Fuller R, Bonfá E, Guedes LKN, D’Alleva PSR, Borba EF. Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy. Clin Rheumatol 2014; 33 (04) 505-509
  • 22 Safkan B, Knuuttila M. Corticosteroid therapy and periodontal disease. J Clin Periodontol 1984; 11 (08) 515-522
  • 23 Lima TR, Costa LS, Cruz Neto ES, Mesquita NB, Brito LF, Silveira VRS. Perda dentária e doença periodontal associada ou não a condições sistêmicas revisão de literatura. Periodontia. 2019; 29 (02) 3-42
  • 24 Moghadam SA, Shirzaiy M, Risbaf S. The association between periodontitis and respiratory disease. J Nepal Health Res Counc 2017; 15 (01) 1-6
  • 25 Lertpimonchai A, Rattanasiri S, Arj-Ong Vallibhakara S, Attia J, Thakkinstian A. The association between oral hygiene and periodontitis: a systematic review and meta-analysis. Int Dent J 2017; 67 (06) 332-343
  • 26 Dantas FT, Martins SHL, Dantas ATM, Gnoatto N. Stress and periodontal disease: a literature review. Periodontia 2016; 26 (03) 19-28