CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2020; 39(03): 217-221
DOI: 10.1055/s-0040-1713918
Case Report | Relato de Caso

A Diffuse Leptomeningeal Glioneural Tumor Case Producing Hydrocephalus and Polyradiculopathy

Relato de um caso de tumor glioneuronal leptomeníngeo difuso produzindo hidrocefalia e polirradiculopatia
1   Division of Neurosurgery, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil
,
2   Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
,
Renan Ribeiro Ribeiro
3   Division of Anatomical Pathology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
,
2   Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
,
2   Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
› Author Affiliations

Abstract

The present report describes the case of a male 17-year-old patient who progressively developed a hydrocephalus and polyradiculopathy due to involvement of central nervous system (CNS) by a diffuse leptomeningeal glioneuronal tumor (DLGNT). The tumor had partial remission in response to the treatment with radiotherapy plus procarbazine, lomustine, and vincristine (PCV) chemotherapy, and the patient had improvement in function and pain levels. The current knowledge about DLGNT, including its clinical manifestations, imaging findings, histological characteristics, and treatment are revised and discussed in the present paper.

Resumo

No presente relato de caso descrevemos um paciente do sexo masculino, com 17 anos de idade, que desenvolveu progressivamente hidrocefalia e polirradiculopatia, devido ao envolvimento do sistema nervoso central por um tumor glioneuronal leptomeníngeo difuso (TGNLD). Nesse caso peculiar obtivemos remissão parcial da neoplasia, melhora funcional e controle álgico do paciente após o tratamento com radioterapia e quimioterapia adjuvante com procarbazina, lomustina e vincristina (PCV). O conhecimento atual sobre TGNLD, incluindo suas manifestações clínicas, achados de imagem, características histológicas e tratamento são revisados e discutidos neste artigo.

Compliance with Ethical Standards

The present case report has not been previously presented or published in part or in full.


The present case report has been written in accordance with Committee on Publication Ethics (COPE) guidelines and complies with the Case Report (CARE) guidelines.


Patient Consent

The patient has agreed with the present case report article and has consented to its submission to the journal.




Publication History

Received: 17 February 2020

Accepted: 12 May 2020

Article published online:
31 July 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Rio de Janeiro, Brazil

 
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