CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2020; 10(02): 63-67
DOI: 10.1055/s-0040-1713840
Original Article

Evaluation of Staging at Diagnosis and Its Relationship with Survival Duration in Nonsmall Cell Lung Cancer Cases in Southern India

Giridhar Belur Hosmane
1   Department of Pulmonary Medicine, K.S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
,
Rajesh Venkataram
1   Department of Pulmonary Medicine, K.S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
,
Vijith Shetty
2   Department of Medical Oncology, K.S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
,
Ankeeta Menona Jacob
3   Department of Community Medicine, K.S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
,
Anirban Chakraborty
4   Centre for Science Education and Research, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India
› Institutsangaben

Abstract

Introduction Lung cancer is one of the most common forms of malignancies worldwide. It is usually diagnosed in late stages due to overlapping symptoms with other respiratory illnesses. Identifying the stage at presentation to tertiary care determines the prognosis of a patient to large extent.

Methods Histologically/cytologically confirmed cases of nonsmall cell lung cancer subjects were included for prospective observational study. Stages of the disease at presentation and survival duration in the patients were studied and the data were compared between two groups: those that accepted and those that refused standard treatment.

Results Ninety-two percent of our patients presented either stage IIIB or stage IV disease at the time of diagnosis. Median duration of survival in the group that took standard treatment was 6 months, whereas in the group that refused standard treatment, it was 4 months. Based on their smoking status, the median duration of survival was 4 months among smokers, whereas it was 9 months among nonsmokers with a log rank test value of 3.040 and an insignificant p-value of 0.081.

Conclusion More than 90% patients presented in later stages of the disease and there was no survival benefit in patients who were treated with palliative care.



Publikationsverlauf

Artikel online veröffentlicht:
24. Juni 2020

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  • References

  • 1 Behera D. Lung cancer in India: challenges and perspectives. J Thorac Oncol 2017; 12 (01) (supplement) S114-S115
  • 2 Kaur H, Sehgal IS, Bal A. et al. Evolving epidemiology of lung cancer in India: reducing non-small cell lung cancer-not otherwise specified and quantifying tobacco smoke exposure are the key. Indian J Cancer 2017; 54 (01) 285-290
  • 3 Singh N, Behera D. Lung cancer epidemiology and clinical profile in North India: similarities and differences with other geographical regions of India. Indian J Cancer 2013; 50 (04) 291
  • 4 Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest 2009; 136 (01) 260-271
  • 5 Raj S, Piang LK, Nair KS, Tiwari VK, Kaur H, Singh B. Awareness regarding risk factors, symptoms and treatment facilities for cancer in selected states of India. Asian Pac J Cancer Prev 2012; 13 (08) 4057-4062
  • 6 Chen C-Y, Wang J-Y, Chien Y-C, Chen K-Y, Yu C-J, Yang P-C. Lung cancer mimicking pulmonary tuberculosis in a TB-endemic country: the role of early invasive diagnostic procedures. Lung Cancer Manag 2015; 4 (01) 13 DOI: 10.2217/lmt.14.46.
  • 7 Hong S, Park EC, Kim TH. et al. Effect of pre existing respiratory conditions on survival of lung cancer patients: a nationwide population-based cohort study. Asia Pac J Clin Oncol 2018; 14 (02) e71-e80
  • 8 Pakseresht S, Ingle GK, Garg S, Sarafraz N. Stage at diagnosis and delay in seeking medical care among women with breast cancer, Delhi, India. Iran Red Crescent Med J 2014; 16 (12) e14490
  • 9 Farbicka P, Nowicki A. Palliative care in patients with lung cancer. Contemp Oncol (Pozn) 2013; 17 (03) 238-245
  • 10 Lee SJ, Lee J, Park YS. et al. Impact of smoking on mortality of patients with non-small cell lung cancer. Thorac Cancer 2014; 5 (01) 43-49
  • 11 Clément-Duchêne C, Stock S, Xu X. et al. Survival among never-smokers with lung cancer in the cancer care outcomes research and surveillance study. Ann Am Thorac Soc 2016; 13 (01) 58-66
  • 12 Subramanian J, Govindan R. Lung cancer in never smokers: a review. J Clin Oncol 2007; 25 (05) 561-570