CC BY-NC-ND 4.0 · Annals of the National Academy of Medical Sciences (India)
DOI: 10.1055/s-0040-1713839
Review Article

Review of Clinical Trials in COVID-19: Trying to Solve the Clinicians’ Conundrum

Amita Athavale
1  Department of Pulmonary Medicine and Environmental Pollution Research Centre, Seth GS Medical College and KEM Hospital, India
,
Vijay Khatri
1  Department of Pulmonary Medicine and Environmental Pollution Research Centre, Seth GS Medical College and KEM Hospital, India
,
Tanya Athavale
1  Department of Pulmonary Medicine and Environmental Pollution Research Centre, Seth GS Medical College and KEM Hospital, India
,
Hemant Deshmukh
2  Department of Radiology, Seth GS Medical College and KEM Hospital, India
,
Gita Nataraj
3  Department of Microbiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
,
Rahul Bahot
4  Department of Pulmonary Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
› Author Affiliations
  

Abstract

SARS-CoV-2 and the resulting “COVID-19” has escalated into a pandemic and has resulted in significant morbidity and mortality. Currently, there is no approved antiviral treatment available. Few antiviral agents are undergoing clinical trials for their safety and efficacy against COVID-19. With various repurposed drugs under evaluation, treatment approaches range from search for an effective antiviral, immunomodulation and anticoagulation, use of point-of-care ultrasound to novel ventilatory strategies. Newer agents targeting the inflammatory pathway are also under investigation. There are more than 1955 ongoing clinical trials of repurposed and novel agents. Here we review some of the ongoing trials that have published, at least, interim results of treating patients with COVID-19.



Publication History

Publication Date:
23 July 2020 (online)

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