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Semin Neurol 2020; 40(04): 353-358
DOI: 10.1055/s-0040-1713622
Review Article

History of Chronic Traumatic Encephalopathy

Robert C. Cantu
1   Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, Massachusetts
,
Charles Bernick 
2   Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada
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Abstract

The long-term effects of repetitive head impacts have been recognized for close to a century. What is now referred to as chronic traumatic encephalopathy (CTE) was first described by Martland in 1928 in a series of boxers. Over the years, several important articles were published, including Critchley's 1957 report where he introduced the term “chronic traumatic encephalopathy,” Robert's study in 1969 which provided evidence of the prevalence of neurological impairment in retired fighters, and Corsellis' initial description of the pathology of CTE. However, what brought public attention to the issue of CTE in sports were the postmortem findings of CTE pathology in professional American football players, initially reported by Omalu and subsequently in a large series by McKee. There is now standardization of pathological criteria for CTE and recognition that it can be seen across all activities that involve repetitive head impacts.

Keywords

chronic traumatic encephalopathy - brain damage - natural history


Publication History

Article published online:
10 August 2020

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  • References

  • 1 Martland HS. Punch drunk. JAMA 1928; 91: 1103-1107
    CrossrefPubMedGoogle Scholar
  • 2 Osnato M, Giliberti V. Postconcussion neurosis-traumatic encephalitis: a conception of postconcussion phenomena. Arch Neurol Psychiatry 1927; 18: 181-214
    CrossrefPubMedGoogle Scholar
  • 3 Osnato M. The role of trauma in various neuropsychiatric conditions. Am J Psychiatry 1929; 86: 643060
    PubMedGoogle Scholar
  • 4 Parker HL. Traumatic encephalopathy (“Punch Drunk”) of professional pugilists. J Neurol Psychopathol 1934; 15 (57) 20-28
    CrossrefPubMedGoogle Scholar
  • 5 Millspaugh JA. Dementia pugilistica. U S Nav Med Bull 1937; 35: 297-303
    PubMedGoogle Scholar
  • 6 Courville CB. Punch drunk. Its pathogenesis and pathology on the basis of a verified case. Bull Los Angel Neuro Soc 1962; 27: 160-168
    PubMedGoogle Scholar
  • 7 Bowman KM, Blau A. Psychotic states following head and brain injury in adults and children. In: Brock S. , ed. Injuries of the Skull Brain and Spinal Cord: Neuropsychiatric, Surgical, and Medico-Legal Aspects. Baltimore, MD: Williams & Wilkins; 1940
    CrossrefGoogle Scholar
  • 8 Critchley M. Medical aspects of boxing, particularly from a neurological standpoint. BMJ 1957; 1 (5015): 357-362
    CrossrefPubMedGoogle Scholar
  • 9 Busse EW, Silverman AJ. Electroencephalographic changes in professional boxers. J Am Med Assoc 1952; 149 (17) 1522-1525
    CrossrefPubMedGoogle Scholar
  • 10 Kaplan HA, Browder J. Observations on the clinical and brain wave patterns of professional boxers. J Am Med Assoc 1954; 156 (12) 1138-1144
    CrossrefPubMedGoogle Scholar
  • 11 Betti OO, Ottino CA. Pugilistic encephalopathy. Acta Neurol Latinoam 1969; 15: 47-51
    PubMedGoogle Scholar
  • 12 Blonstein JL, Clarke E. Further observations on the medical aspects of amateur boxing. BMJ 1957; 1 (5015): 362-364
    CrossrefPubMedGoogle Scholar
  • 13 Brayne CEG, Dow L, Calloway SP, Thompson RJ. Blood creatine kinase isoenzyme BB in boxers. Lancet 1982; 2 (8311): 1308-1309
    CrossrefPubMedGoogle Scholar
  • 14 Tnn B, O'Connor PJ. Incidence of boxing injuries in the Royal Air Force in the United Kingdom, 1953–1966l Br. J Industr Med 1968; 25: 326-329
    PubMedGoogle Scholar
  • 15 Colmant HJ, Dotzauer G. Analyse eines todlich ausegangenen Boxkampfes mit ungewohnlich schweren cerebralen Schaden. Rechtsmedizin 1980; 84: 263-278
    CrossrefPubMedGoogle Scholar
  • 16 Courville CB. The mechanism of boxing fatalities Report of an unusual case with severe brain lesions incident to impact of boxer's head against the ropes. Bull Los Angel Neuro Soc 1964; 29: 59-69
    PubMedGoogle Scholar
  • 17 Govons SR. Brain concussion and posture--the knockdown blow of the boxing ring. Confin Neurol 1968; 30 (02) 77-84
    CrossrefPubMedGoogle Scholar
  • 18 Jedliński J, Gatarski J, Szymusik A. Chronic posttraumatic changes in the central nervous system in pugilists. Pol Med J 1970; 9 (03) 743-752
    PubMedGoogle Scholar
  • 19 Jedliński J, Gatarski J, Szymusik A. Encephalopathia pugilistica (punch drunkeness). Acta Med Pol 1971; 12 (03) 443-451
    PubMedGoogle Scholar
  • 20 Johnson J. Organic psychosyndromes due to boxing. Br J Psychiatry 1969; 115 (518) 45-53
    CrossrefPubMedGoogle Scholar
  • 21 Kaste M, Kuurne T, Vilkki J, Katevuo K, Sainio K, Meurala H. Is chronic brain damage in boxing a hazard of the past?. Lancet 1982; 2 (8309): 1186-1188
    CrossrefPubMedGoogle Scholar
  • 22 Khosla T, Hitchens RAN. Johnny Owen's ill-fated fight. Lancet 1980; 2 (8206): 1254-1255
    CrossrefPubMedGoogle Scholar
  • 23 Mawdsley C, Ferguson FR. Neurological disease in boxers. Lancet 1963; 2 (7312): 795-801
    CrossrefPubMedGoogle Scholar
  • 24 Paul M. A fatal injury at boxing; traumatic decerebrate rigidity. BMJ 1957; 1 (5015): 364-366
    CrossrefPubMedGoogle Scholar
  • 25 Payne EE. Brains of boxers. Neurochirurgia (Stuttg) 1968; 11 (05) 173-188
    PubMedGoogle Scholar
  • 26 Spillane JD. Five boxers. BMJ 1962; 2 (5314): 1205-1210
    CrossrefPubMedGoogle Scholar
  • 27 Roberts AH. Brain damage in boxers. London: Pitman. Med Sci 1969; 61-99
    PubMedGoogle Scholar
  • 28 Unterharnscheidt F. About boxing: review of historical and medical aspects. Tex Rep Biol Med 1970; 28 (04) 421-495
    PubMedGoogle Scholar
  • 29 Corsellis JA, Bruton CJ, Freeman-Browne D. The aftermath of boxing. Psychol Med 1973; 3 (03) 270-303
    CrossrefPubMedGoogle Scholar
  • 30 Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 2005; 57: 128-134
    CrossrefPubMedGoogle Scholar
  • 31 Fainaru-Wada M, Fainaru S. League of Denial. New York, NY: Penguin Random House; 2018
    Google Scholar
  • 32 Homeopathic Medical Society of the State of Pennsylvania. Psychoneurosis. Habnemannian Monthly 1933; 68: 305-306
    PubMedGoogle Scholar
  • 33 Health Dig Punch-drunk boxers and football players. N Y State J Med 1936; 36: 1654
    PubMedGoogle Scholar
  • 34 Scully F. Punch-drunk football stars. Milwaukee Journal, September 29, 19373
    PubMedGoogle Scholar
  • 35 Scully F. Stumble-backs – Does football make players stupid?. Liberty 1937; 14 (41) 35-37
    PubMedGoogle Scholar
  • 36 Montenigro PH, Corp DT, Stein TD, Cantu RC, Stern RA. Chronic traumatic encephalopathy: historical origins and current perspective. Annu Rev Clin Psychol 2015; 11: 309-330
    CrossrefPubMedGoogle Scholar
  • 37 McKee AC, Cantu RC, Nowinski CJ. , et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68 (07) 709-735
    CrossrefPubMedGoogle Scholar
  • 38 McKee A, Stern R, Nowinski C. , et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2012; (01) 1-22
    PubMedGoogle Scholar
  • 39 McKee AC, Cairns NJ, Dickson DW. , et al; TBI/CTE Group. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol 2016; 131 (01) 75-86
    CrossrefPubMedGoogle Scholar