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CC BY-NC-ND 4.0 · Eur J Dent 2020; 14(03): 502-510
DOI: 10.1055/s-0040-1713306
Case Report

Metastatic Biphasic Primitive Tumor in the Mandible of a Child

Tiago Novaes Pinheiro
1   Department of Oral Pathology and Oral Medicine, Surgical Pathology and Oral and Maxillofacial Pathology Service, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil
,
Milena Gomes Melo Leite
2   Department of Oral Pathology and Oral Medicine, Surgical Pathology and Oral and Maxillofacial Pathology Service, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil
,
Fábio Arruda Bindá
3   Department of Head and Neck Oncology, Fundação Centro de Controle de Oncologia do Estado do Amazonas, Planalto, Manaus-AM, Brazil
,
André Luiz Tannus Dutra
4   Department of Pediatric Dentistry, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil
,
Naelka Sarmento
4   Department of Pediatric Dentistry, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil
,
Lioney Nobre Cabral
5   Department of Oral Pathology and Oral Medicine, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil
,
Alberto Consolaro
6   Department of Oral Pathology, Bauru School of Dentistry, University of São Paulo, Bauru-SP, Brazil
,
Carlos Eduardo Bacchi
7   Department of Pathology, Laboratório Bacchi Ltd., LB, Botucatu-SP, Brazil
› Author Affiliations Funding None.
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Abstract

Pediatric mandibular tumors present an aggressive biological behavior and difficult diagnosis. A wide range of odontogenic and nonodontogenic tumors comprise the spectrum of these lesions. We report a case of a 1-year-old male child patient showing facial asymmetry symptomatic of an expansive lesion extending throughout the body and ramus of the left hemimandible with a diameter of 8 cm. The histopathological report suggested a high-grade mucoepidermoid carcinoma (MEC), recommending further immunohistochemical investigation of the ectomesenchymal or neuroectodermal origin of the tumor cells. The patient evolved with extensive bilateral pleural effusion followed by metastasis in the middle third of the right humerus, and died 2 months after the first biopsy procedure by acute renal failure with tubular necrosis, before a final inconclusive immunohistochemical report was reached. The lack of resources for less-favored regions of Brazil impairs rapid biomolecular examinations such as immunohistochemical resulting in delay of appropriate therapeutic procedures.

Keywords

PNET - mucoepidermoid carcinoma - carcinosarcoma - Ewing’s sarcoma - odontogenic tumors - metastasis


Publication History

Article published online:
15 June 2020

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