Thromb Haemost 2020; 120(08): 1233-1236
DOI: 10.1055/s-0040-1712918
Letter to the Editor

Sars-CoV-2 Induced Coagulopathy and Prognosis in Hospitalized Patients: A Snapshot from Italy

Betti Giusti
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Anna Maria Gori
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Manuel Alessi
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Angela Rogolino
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Elena Lotti
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Daniela Poli
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Elena Sticchi
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Alessandro Bartoloni
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Alessandro Morettini
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Carlo Nozzoli
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Adriano Peris
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Filippo Pieralli
2  Department of Cardiotoracovascolare, Azienda Ospedaliero-Universitaria Careggi Firenze, Firenze, Italy
,
Loredana Poggesi
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Niccolo Marchionni
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Rossella Marcucci
1  Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
› Author Affiliations

After Wuhan, in China, Italy has become the European country with the highest number of cases and deaths by Sars-Cov-2.[1] [2]

It has been reported from China the presence of altered coagulation parameters in a significant proportion of hospitalized patients.[3] [4] [5] In addition, increased D-dimer (DD) levels have gained particular attention as predictors of acute respiratory distress syndrome development, the need of intensive care unit(ICU) admission, or death.[6] [7] It is well known that DD is a highly nonspecific marker which may be only the mirror of the clotting activation following the inflammatory process.[8] [9] Nevertheless, several thrombotic complications have been reported in patients with Covid-19 treated in ICU and the possible treatment with heparin appears to be very attractive.[10]

Before this therapeutic application, it is mandatory to verify and report to the scientific community which is the trend of coagulation parameters, so that we can accumulate several observations useful to design ad hoc interventional trials.

In this scenario, we decided to analyze the routine coagulation parameters—prothrombin time (PT), activated partial thromboplastin time (aPTT), DD, and platelet count—of a consecutive series of patients with documented infection by Sars-Cov-2 hospitalized in Careggi Hospital, Florence, Italy.



Publication History

Received: 14 April 2020

Accepted: 06 May 2020

Publication Date:
26 May 2020 (online)

Georg Thieme Verlag KG
Stuttgart · New York